2020
3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells
Müller A, Schmidt D, Xu CS, Pang S, D’Costa J, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M. 3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells. Journal Of Cell Biology 2020, 220: e202010039. PMID: 33326005, PMCID: PMC7748794, DOI: 10.1083/jcb.202010039.Peer-Reviewed Original ResearchConceptsInsulin secretory granulesΒ-cellsSecretory granulesPrimary mammalian cellsFirst 3D reconstructionPrimary mouse β-cellsMouse β-cellsMammalian cellsMicrotubule organizationPlasma membraneIntracellular traffickingIslet β-cellsMicrotubule networkMicrotubulesUnprecedented resolutionCell constituentsMicrotubule numberCell functionGolgi apparatiCentriolesCellsEndocrine cellsGlucose stimulationEndomembranesGranulesA Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell 2020, 27: 125-136.e7. PMID: 32579880, PMCID: PMC7303620, DOI: 10.1016/j.stem.2020.06.015.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionHuman disease-relevant cellsSARS-CoV-2 tropismCOVID-19 pathophysiologyExpression of chemokinesRecent clinical studiesHuman pancreatic beta cellsCOVID-19SARS-CoV-2Pancreatic beta cellsLiver organoidsPancreatic endocrine cellsRespiratory failureDopaminergic neuronsClinical studiesPrimary human isletsVirus infectionAutopsy samplesBeta cellsHuman isletsEndocrine cellsOrgan systemsInfectionCholangiocyte organoidsDisease-relevant cells
2019
C‐terminal phosphorylation of latrophilin‐1/ADGRL1 affects the interaction between its fragments
Rahman M, Manser C, Benlaouer O, Suckling J, Blackburn J, Silva J, Ushkaryov Y. C‐terminal phosphorylation of latrophilin‐1/ADGRL1 affects the interaction between its fragments. Annals Of The New York Academy Of Sciences 2019, 1456: 122-143. PMID: 31553068, DOI: 10.1111/nyas.14242.Peer-Reviewed Original ResearchConceptsN-terminal fragmentG protein-coupled receptorsC-terminal fragmentLatrophilin-1Protein-coupled receptorsAdhesion G protein-coupled receptorsProtein tyrosine phosphatase σG protein-mediated signalingProtein-mediated signalingPhosphorylated C-terminal fragmentsTerminal phosphorylationIndependent proteinsPlasma membraneSeparate proteinsΑ-latrotoxinAffinity columnProteinEndocrine cellsFragmentsHigh affinityLow affinityMultiple sitesCopurifiesDephosphorylationComplexes
2016
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
Nabulsi N, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. Journal Of Nuclear Medicine 2016, 57: 777-784. PMID: 26848175, DOI: 10.2967/jnumed.115.168179.Peer-Reviewed Original ResearchConceptsSynaptic vesicle glycoprotein 2AWhole-body biodistributionPET radiotracersNonhuman primatesDose-limiting organHigher free fractionGray matter regionsBaseline VTNondisplaceable distribution volumeAntiepileptic drugsVitro inhibition constantSynaptic densityPreclinical evaluationMonkey brainDistribution volumeArterial samplingEndocrine cellsRegional volumesMatter regionsRhesus macaquesPET tracersUCBFree fractionBrainTarget occupancy
2015
Pancreatic Islet-Like Three-Dimensional Aggregates Derived from Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice
Shim J, Kim J, Han J, An S, Jang Y, Son J, Woo D, Kim S, Kim J. Pancreatic Islet-Like Three-Dimensional Aggregates Derived from Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice. Cell Transplantation 2015, 24: 2155-2168. PMID: 25397866, DOI: 10.3727/096368914x685438.Peer-Reviewed Original ResearchConceptsDiabetic miceHuman embryonic stem cellsClinical islet transplantationBlood glucose levelsMature pancreatic endocrine cellsPancreatic endocrine cellsStem cellsInhibition of NotchAmeliorate hyperglycemiaIslet transplantationPancreatic hormonesGlucose levelsPancreatic endodermDonor isletsPancreatic featuresActivin APharmacological drugsEndocrine cellsIncreased expressionThree-dimensional aggregatesExpression of Neurog3Transient upregulationProgenitor cellsRetinoic acidActivin βBVagal Sensory Neuron Subtypes that Differentially Control Breathing
Chang R, Strochlic D, Williams E, Umans B, Liberles S. Vagal Sensory Neuron Subtypes that Differentially Control Breathing. Cell 2015, 161: 622-633. PMID: 25892222, PMCID: PMC4842319, DOI: 10.1016/j.cell.2015.03.022.Peer-Reviewed Original ResearchConceptsSlow-conducting C fibersVagus nervePulmonary endocrine cellsVagus nerve afferentsC-fibersFast-conducting A fibersSensory neuronsShallow breathingNeuroepithelial bodiesNerve afferentsAutonomic functionImpact heart rateA fibersAnatomical mappingBrainstem targetsGastric pressureOptogenetic stimulationVagal controlHeart rateNeuronsNormal respirationEndocrine cellsBreathingLungP2RY1
2002
Increased Endocrine Cells in Treated Rectal Adenocarcinomas
Shia J, Tickoo S, Guillem J, Qin J, Nissan A, Hoos A, Stojadinovic A, Ruo L, Wong W, Paty P, Weiser M, Minsky B, Klimstra D. Increased Endocrine Cells in Treated Rectal Adenocarcinomas. The American Journal Of Surgical Pathology 2002, 26: 863-872. PMID: 12131153, DOI: 10.1097/00000478-200207000-00004.Peer-Reviewed Original ResearchConceptsChromogranin-positive cellsTreat rectal adenocarcinomaRectal adenocarcinomaChromogranin positivityNeoadjuvant therapyResected specimenTreatment responsePosttreatment specimensPretreatment biopsiesTumor cellsAbnormal p53 protein expressionTumors treated with radiotherapyCases of rectal adenocarcinomaEndocrine cellsDense chromatin patternPosttreatment resection specimensSubstantial treatment responsePretreatment biopsy specimensHematoxylin and eosin sectionsEndocrine differentiationResidual tumor cellsKi67 labeling indexP53 protein expressionDegree of treatment responseChromogranin staining
2001
Synaptic Release of Neurotransmitters
B.Levitan I, Kaczmarek L. Synaptic Release of Neurotransmitters. 2001, 195-222. DOI: 10.1093/oso/9780195145236.003.0009.Peer-Reviewed Original ResearchChemical communicationSecretion of proteinsVertebrate neuromuscular junctionSpecific chemical signalsEvolutionary pressureMembranous vesiclesChemical signalsEndocrine cellsRecipient cellsCell typesNeuronal cellsSecretory cellsMessenger substancesExtracellular spaceMuscle cellsLong axonsCellsNeuromuscular junctionTarget cellsChemical transmittersSynaptic terminalsSynaptic releaseGiant synapseSynaptic junctionsExocytosis
1998
Cell Biology of Secretion
Dannies P. Cell Biology of Secretion. 1998, 3-22. DOI: 10.1002/cphy.cp070101.Peer-Reviewed Original ResearchDocking/fusionCorrect membraneEndocrine cellsMembrane buddingCell biologyMembrane fusionIntracellular transportSynaptic vesiclesDense core granulesSecretory granulesVesiclesEndocytosisNeurotransmitter releaseReconstituted systemExocytosisCore granulesCellsFusion mechanismClathrinYeastCalcium dependenceBuddingBiologyGranulesFusion
1994
Mixed Acinar-Endocrine Carcinomas of the Pancreas
Klimstra D, Rosai J, Heffess C. Mixed Acinar-Endocrine Carcinomas of the Pancreas. The American Journal Of Surgical Pathology 1994, 18: 765-778. PMID: 8037290, DOI: 10.1097/00000478-199408000-00002.Peer-Reviewed Original ResearchConceptsPancreatic neoplasmsEndocrine markersAcinar cell carcinomaRare pancreatic neoplasmEndocrine componentGlandular growth patternAcinar-endocrine carcinomaDouble immunohistochemical stainingEndocrine cellsUnusual tumorWidespread metastasesCell carcinomaImmunohistochemical positivityDivergent differentiationImmunohistochemical stainingFollow-upRare typeHistogenetic relationshipTumorUniform cell populationNeoplasmsPatientsPancreatic enzymesCell populationsEndocrine hormones
1993
Traffic of synaptic vesicle proteins in polarized and nonpolarized cells
Cameron P, Mundigl O, De Camilli P. Traffic of synaptic vesicle proteins in polarized and nonpolarized cells. Journal Of Cell Science. Supplement 1993, 1993: 93-100. PMID: 8144709, DOI: 10.1242/jcs.1993.supplement_17.14.Peer-Reviewed Original ResearchConceptsSV proteinsSynaptic vesiclesSecretory organellesSpecialized secretory organellesSynaptic-like microvesiclesExo-endocytotic recyclingSynaptic vesicle proteinsNon-peptide hormonesEndosomal intermediatesEndocrine cellsNeuronal polarityNonpolarized cellsRecycling pathwayRegulated secretionVesicle proteinsTypical synaptic vesiclesFunctional similarityLarge dense-core vesiclesDense-core vesiclesNeuronal counterpartsVesicular carriersProtein synaptophysinVesicle storesMature neuronsProtein
1991
Multiple preprosomatostatin sorting signals mediate secretion via discrete cAMP- and tetradecanoylphorbolacetate-responsive pathways.
Sevarino K, Stork P. Multiple preprosomatostatin sorting signals mediate secretion via discrete cAMP- and tetradecanoylphorbolacetate-responsive pathways. Journal Of Biological Chemistry 1991, 266: 18507-18513. PMID: 1680862, DOI: 10.1016/s0021-9258(18)55090-0.Peer-Reviewed Original ResearchConceptsRegulated secretory pathwaySecretory pathwayMutant precursorRat preprosomatostatinVesicular stomatitis virus G proteinMature peptide regionVirus G proteinSorting signalsRegulated secretionAmino terminusProteolytic maturationExpression vectorNeuropeptide precursorsSite recognitionG proteinsRIN-5F cellsPeptide regionPathwaySecreted productsMutationsIntracellular productsCellsEndocrine cellsResiduesNeuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium
Kramer R, Kaczmarek L, Levitan E. Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium. Neuron 1991, 6: 557-563. PMID: 1849723, DOI: 10.1016/0896-6273(91)90058-8.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVoltage-gated calcium channelsVoltage-gated Ca2Protein kinase CInactivation of Ca2Pituitary tumor cellsVariety of agentsHormone secretionNeurotransmitter inhibitionIntracellular calciumResult of Ca2Calcium channelsIntracellular Ca2Inhibits Ca2Kinase CEndocrine cellsRoutine useTumor cellsPatch-clamp electrodesPlasma membrane channelsDependent inactivationInhibitionHormoneSecretionCa2The Neuroendocrine Regulation of the Menstrual Cycle
Meyers-Seifer C, Seifer D. The Neuroendocrine Regulation of the Menstrual Cycle. Clinical Perspectives In Obstetrics And Gynecology 1991, 1-21. DOI: 10.1007/978-1-4612-3026-7_1.Peer-Reviewed Original Research
1987
Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours
Buffa R, Rindi G, Sessa F, Gini A, Capella C, Jahn R, Navone F, De Camilli P, Solcia E. Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours. Molecular And Cellular Probes 1987, 1: 367-381. PMID: 3134611, DOI: 10.1016/0890-8508(87)90018-1.Peer-Reviewed Original ResearchConceptsSynaptophysin immunoreactivityNeuroendocrine cellsClear vesiclesGut endocrine tumorsHuman adrenal medullaThyroid medullary carcinomaSmall clear vesiclesNon-chromaffin paragangliomaParathyroid adenomaMedullary carcinomaNeuroendocrine carcinomaNeuroendocrine tumorsCarotid bodyEndocrine tumorsGastrointestinal mucosaLung carcinoidsNerve terminalsPituitary adenomasAdrenal medullaPituitary cellsTumorsEndocrine cellsImmunoreactivityEndocrine granulesGeneral marker
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