Increased Endocrine Cells in Treated Rectal Adenocarcinomas
Shia J, Tickoo S, Guillem J, Qin J, Nissan A, Hoos A, Stojadinovic A, Ruo L, Wong W, Paty P, Weiser M, Minsky B, Klimstra D. Increased Endocrine Cells in Treated Rectal Adenocarcinomas. The American Journal Of Surgical Pathology 2002, 26: 863-872. PMID: 12131153, DOI: 10.1097/00000478-200207000-00004.Peer-Reviewed Original ResearchConceptsChromogranin-positive cellsTreat rectal adenocarcinomaRectal adenocarcinomaChromogranin positivityNeoadjuvant therapyResected specimenTreatment responsePosttreatment specimensPretreatment biopsiesTumor cellsAbnormal p53 protein expressionTumors treated with radiotherapyCases of rectal adenocarcinomaEndocrine cellsDense chromatin patternPosttreatment resection specimensSubstantial treatment responsePretreatment biopsy specimensHematoxylin and eosin sectionsEndocrine differentiationResidual tumor cellsKi67 labeling indexP53 protein expressionDegree of treatment responseChromogranin staining
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