2025
Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis
Yang X, Zhang X, Tian Y, Yang J, Jia Y, Xie Y, Cheng L, Chen S, Wu L, Qin Y, Zhao Z, Zhao D, Wei Y. Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis. Circulation Research 2025, 136: 985-1009. PMID: 40160097, DOI: 10.1161/circresaha.124.326111.Peer-Reviewed Original ResearchConceptsAlternative polyadenylationAssociated with atherosclerosis progressionUntranslated regionRNA sequencingExpression of chemokinesRegulation of cell fateAlternative polyadenylation patternsEfficient mitochondrial translationMetabolic labeling assaysSingle-cell RNA sequencingIntegrated stress responseMyeloid deletionLow-density lipoproteinMonocytes to macrophagesImpairment of protein synthesisPhagocytic impairmentMetabolomic profilesMacrophage maturationPrecursor nicotinamide mononucleotideCirculating monocytesIntegrated stress response inhibitorLesional cellsHistopathological analysisProatherosclerotic effectsNicotinamide mononucleotide treatment
2020
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell 2020, 27: 125-136.e7. PMID: 32579880, PMCID: PMC7303620, DOI: 10.1016/j.stem.2020.06.015.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionHuman disease-relevant cellsSARS-CoV-2 tropismCOVID-19 pathophysiologyExpression of chemokinesRecent clinical studiesHuman pancreatic beta cellsCOVID-19SARS-CoV-2Pancreatic beta cellsLiver organoidsPancreatic endocrine cellsRespiratory failureDopaminergic neuronsClinical studiesPrimary human isletsVirus infectionAutopsy samplesBeta cellsHuman isletsEndocrine cellsOrgan systemsInfectionCholangiocyte organoidsDisease-relevant cells
2019
Migrant memory B cells secrete luminal antibody in the vagina
Oh JE, Iijima N, Song E, Lu P, Klein J, Jiang R, Kleinstein SH, Iwasaki A. Migrant memory B cells secrete luminal antibody in the vagina. Nature 2019, 571: 122-126. PMID: 31189952, PMCID: PMC6609483, DOI: 10.1038/s41586-019-1285-1.Peer-Reviewed Original ResearchConceptsMemory B cellsFemale reproductive tractB cellsPlasma cellsReproductive tractCD4 tissue-resident memory T cellsTissue-resident memory T cellsLower female reproductive tractHerpes simplex virus 2Genital herpes infectionMemory T cellsExpression of chemokinesSimplex virus 2CXCR3-dependent mannerLocal plasma cellsLuminal antibodyMucosal antibodiesHerpes infectionPrimary infectionMucosal barrierSecondary challengeVariety of pathogensT cellsLamina propriaInducible source
2018
Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin
Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML. Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin. Journal Of Investigative Dermatology 2018, 138: 1301-1310. PMID: 29391252, PMCID: PMC6590516, DOI: 10.1016/j.jid.2018.01.006.Peer-Reviewed Original ResearchConceptsMycophenolate mofetil treatmentMyeloid cell numbersMMF therapyMofetil treatmentSystemic sclerosisInflammatory scoreSkin biopsiesCell numberSkin myeloid cellsMyeloid dendritic cellsHalf of patientsRodnan skin scoreImmune cell numbersInflammatory gene signatureExpression of chemokinesProtein levelsCCL2 protein levelsCCL2 mRNA expressionInflammatory signatureDendritic cellsSkin scoreCCL2 mRNAEleven subjectsMonocyte migrationMyeloid cells
2005
Recruitment of CXCR3+ and CCR5+ T Cells and Production of Interferon-γ-Inducible Chemokines in Rejecting Human Arteries
Burns WR, Wang Y, Tang PC, Ranjbaran H, Iakimov A, Kim J, Cuffy M, Bai Y, Pober JS, Tellides G. Recruitment of CXCR3+ and CCR5+ T Cells and Production of Interferon-γ-Inducible Chemokines in Rejecting Human Arteries. American Journal Of Transplantation 2005, 5: 1226-1236. PMID: 15888026, DOI: 10.1111/j.1600-6143.2005.00892.x.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBlood VesselsCells, CulturedChemokine CCL4Chemokine CCL5Chemokine CXCL10Chemokine CXCL11Chemokine CXCL9Chemokines, CXCEndothelial CellsGraft RejectionHeart TransplantationHumansIntercellular Signaling Peptides and ProteinsInterferon-gammaLeukocytesMacrophage Inflammatory ProteinsMuscle, Smooth, VascularReceptors, CCR5Receptors, ChemokineReceptors, CXCR3Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesTransplantation, HomologousVascular DiseasesConceptsT cellsIFN-gamma-secreting T cellsClinical allograft rejectionRecruitment of CXCR3Allogeneic T cellsVascular smooth muscle cellsExpression of chemokinesCoronary artery segmentsProduction of interferonDifferent vascular compartmentsSmooth muscle cellsReal-time RT-PCRImmunodeficient mouse hostsAcute rejectionAllograft rejectionInducible chemokinesMicrovascular inflammationConduit arteriesIP-10MIP-1betaImmunological privilegeTh1 cellsChemokine mRNAChemokine receptorsI-TAC
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