2024
The Impact of Next-generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Desmoplastic Melanocytic Neoplasms
Chen A, Sharma N, Patel P, Olivares S, Bahrami A, Barnhill R, Blokx W, Bosenberg M, Busam K, de La Fouchardière A, Duncan L, Elder D, Ko J, Landman G, Lazar A, Lezcano C, Lowe L, Maher N, Massi D, Messina J, Mihic-Probst D, Parker D, Redpath M, Scolyer R, Shea C, Spatz A, Tron V, Xu X, Yeh I, Yun S, Zembowicz A, Gerami P. The Impact of Next-generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Desmoplastic Melanocytic Neoplasms. The American Journal Of Surgical Pathology 2024, 48: 708-718. PMID: 38590014, DOI: 10.1097/pas.0000000000002226.Peer-Reviewed Original ResearchConceptsDesmoplastic melanomaMelanocytic neoplasmsNext-generation sequencingInterobserver agreementDiagnostic accuracyHematoxylin and eosin sectionsImpact of next-generation sequencingDiagnostic scenariosMetastatic diseaseDesmoplastic tumorsMelanocytic tumorsMelanoma casesMelanoma geneticsFleiss' multirater kappaAccurate diagnosisNeoplasmsMelanomaAncillary toolDegree of improvementMultirater kappaDiagnosisGenomic findingsTumorGenome sequencing resultsPathologists
2016
A Practical Approach to the Classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WD-NET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas
Tang L, Basturk O, Sue J, Klimstra D. A Practical Approach to the Classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WD-NET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas. The American Journal Of Surgical Pathology 2016, 40: 1192-1202. PMID: 27259015, PMCID: PMC4988129, DOI: 10.1097/pas.0000000000000662.Peer-Reviewed Original ResearchConceptsHigh-grade pancreatic neuroendocrine neoplasmsAbnormal expression of p53PD-NECsWD-NETsPancreatic neuroendocrine neoplasmsNeuroendocrine neoplasmsExpression of p53Loss of DAXXNeuroendocrine carcinomaPoor-differentiated neuroendocrine carcinomasHigh-grade neuroendocrine neoplasmsAccurate diagnosisEvaluate immunohistochemical stainingG3 neuroendocrine neoplasmsHigh-grade progressionWHO grade 3Hematoxylin and eosin sectionsDisease-specific survivalAbnormal expressionGroup of tumorsDegree of diagnostic concordanceWHO classification schemeATRX protein expressionCoexisting adenocarcinomaAbnormal p53
2002
Increased Endocrine Cells in Treated Rectal Adenocarcinomas
Shia J, Tickoo S, Guillem J, Qin J, Nissan A, Hoos A, Stojadinovic A, Ruo L, Wong W, Paty P, Weiser M, Minsky B, Klimstra D. Increased Endocrine Cells in Treated Rectal Adenocarcinomas. The American Journal Of Surgical Pathology 2002, 26: 863-872. PMID: 12131153, DOI: 10.1097/00000478-200207000-00004.Peer-Reviewed Original ResearchConceptsChromogranin-positive cellsTreat rectal adenocarcinomaRectal adenocarcinomaChromogranin positivityNeoadjuvant therapyResected specimenTreatment responsePosttreatment specimensPretreatment biopsiesTumor cellsAbnormal p53 protein expressionTumors treated with radiotherapyCases of rectal adenocarcinomaEndocrine cellsDense chromatin patternPosttreatment resection specimensSubstantial treatment responsePretreatment biopsy specimensHematoxylin and eosin sectionsEndocrine differentiationResidual tumor cellsKi67 labeling indexP53 protein expressionDegree of treatment responseChromogranin staining
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