2010
Goniothalamin Induces Coronary Artery Smooth Muscle Cells Apoptosis: The p53-Dependent Caspase-2 Activation Pathway
Chan K, Rajab N, Siegel D, Bin Din L, Ross D, Inayat-Hussain S. Goniothalamin Induces Coronary Artery Smooth Muscle Cells Apoptosis: The p53-Dependent Caspase-2 Activation Pathway. Toxicological Sciences 2010, 116: 533-548. PMID: 20498002, DOI: 10.1093/toxsci/kfq151.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAmino Acid Chloromethyl KetonesApoptosisCaspase 2Cells, CulturedCytochromes cDose-Response Relationship, DrugEnzyme ActivationHumansHydrogen PeroxideMembrane Potential, MitochondrialMuscle, Smooth, VascularMyocytes, Smooth MuscleNAD(P)H Dehydrogenase (Quinone)Oxygen ConsumptionPyronesSuperoxidesTumor Suppressor Protein p53ConceptsCoronary artery smooth muscle cellsCaspase-2Pan-caspase inhibitor benzyloxycarbonylMitochondrial membrane potential lossAsp-fluoromethyl ketoneRole of mitochondriaExternalization of phosphatidylserineMembrane potential lossCaspase-3 cleavageMitochondrial releaseCaspase-8Molecular mechanismsUpstream signalsArtery smooth muscle cellsDNA damage
2007
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132
Zafar K, Inayat‐Hussain S, Ross D. A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. Journal Of Neurochemistry 2007, 102: 913-921. PMID: 17504267, DOI: 10.1111/j.1471-4159.2007.04637.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsApoptosisCaspasesCell Line, TransformedCysteine Proteinase InhibitorsDopamineDose-Response Relationship, DrugEnzyme ActivationLeupeptinsMesencephalonNerve DegenerationNeuronsOxidative StressParkinson DiseaseProteasome Endopeptidase ComplexRatsReactive Oxygen SpeciesSubstantia NigraConceptsN-acetylcysteineN27 cellsParkinson's diseaseProteasomal inhibitionAbility of dopamineCell deathCaspase-9Dopaminergic neuronsDopaminergic cellsMesencephalic cellsDA treatmentConcentration-dependent apoptosisMG132-induced apoptosisCaspase-dependent apoptosisDiseaseSelective lossMitochondrial membrane potential lossReactive oxygen speciesDopamineCaspase-3Membrane potential lossApoptosisInhibitionQuinoid metabolitesCaspase-2
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply