2021
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Powell SK, O’Shea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, Iskhakova M, Lambert T, Valada A, Liao W, Ho SM, Slesinger PA, Huckins LM, Akbarian S, Brennand KJ. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular Psychiatry 2021, 28: 1970-1982. PMID: 34493831, PMCID: PMC8898985, DOI: 10.1038/s41380-021-01273-0.Peer-Reviewed Original ResearchConceptsInduced dopaminergic neuronsDopaminergic neuronsMidbrain dopaminergic neuron developmentNeuron identityHuman induced pluripotent stem cellsCannabis use disorderDopaminergic neuron developmentAction potential durationGlutamatergic neuronsDopamine synthesisSpontaneous burstsPotential durationUse disordersNeuronal subtypesPsychiatric diseasesBipolar disorderElectrophysiological propertiesDisease riskHyperpolarization potentialPsychiatric disease riskNeuron developmentOscillatory activityNeuronsHeterogenous cell populationsCell populations
2020
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
McCutcheon RA, Krystal JH, Howes OD. Dopamine and glutamate in schizophrenia: biology, symptoms and treatment. World Psychiatry 2020, 19: 15-33. PMID: 31922684, PMCID: PMC6953551, DOI: 10.1002/wps.20693.Peer-Reviewed Original ResearchDopamine systemAberrant dopamine signallingStriatal dopamine synthesisNovel pharmacological therapiesPathophysiology of schizophreniaEnvironmental risk factorsPharmacological therapyGlutamatergic dysfunctionDopaminergic functionRisk factorsGlutamate systemDopamine synthesisGenetic risk variantsPreclinical studiesPsychotic symptomsDopamine functionNew treatmentsNeural circuitsDopamine signalingNeuronal signalingSchizophreniaConsistent findingRisk variantsSymptomsGlutamate
2013
Renalase regulates renal dopamine and phosphate metabolism
Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV. Renalase regulates renal dopamine and phosphate metabolism. American Journal Of Physiology. Renal Physiology 2013, 305: f839-f844. PMID: 23863468, PMCID: PMC3761288, DOI: 10.1152/ajprenal.00616.2012.Peer-Reviewed Original ResearchConceptsRenal DA synthesisKO micePO4 excretionDA synthesisSodium-phosphate cotransporter Npt2aCatecholamine-degrading enzymeIntrinsic renal defectRenal dopamine synthesisWild-type miceKO mice showKnockout mouse modelDopa excretionRenalase deficiencySevere hypophosphatemiaRenal dopamineSerum PO4Urinary dopaminePhosphate excretionRegular dietDietary phosphateDopamine synthesisMouse modelMice showCompensatory increaseRenal defectsPostnatal manganese exposure does not alter dopamine autoreceptor sensitivity in adult and adolescent male rats
McDougall SA, Mohd-Yusof A, Kaplan GJ, Abdulla ZI, Lee RJ, Crawford CA. Postnatal manganese exposure does not alter dopamine autoreceptor sensitivity in adult and adolescent male rats. European Journal Of Pharmacology 2013, 706: 4-10. PMID: 23458069, PMCID: PMC3633626, DOI: 10.1016/j.ejphar.2013.02.030.Peer-Reviewed Original ResearchConceptsDopamine autoreceptor sensitivityEarly Mn exposureAutoreceptor sensitivityDopamine autoreceptorsMale ratsDopamine synthesisMn exposureDorsal striatumD2 receptor concentrationsPostnatal manganese exposureStriatal DOPA accumulationDopamine transporter levelsAdolescent male ratsPostnatal day 1Autoreceptor effectsApomorphine treatmentDOPA accumulationPD-1Haloperidol treatmentPresynaptic mechanismsControl ratsDOPA levelsD2 receptorsLong-term reductionAdult rats
2011
Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model
Wolff EF, Gao X, Yao KV, Andrews ZB, Du H, Elsworth JD, Taylor HS. Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model. Journal Of Cellular And Molecular Medicine 2011, 15: 747-755. PMID: 20406327, PMCID: PMC2998585, DOI: 10.1111/j.1582-4934.2010.01068.x.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDopaminergic neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDopamine metabolite concentrationsPD mouse modelStem cell transplantationDisease modelsSite of lesionParkinson's disease modelPyramidal cell bodiesPatch-clamp recordingsMesenchymal stem-like cellsAllogenic stem cellsStem cellsStem-like cellsCell transplantationStriatal dopamineNeural markers nestinCentral neuronsDopaminergic cellsDendritic projectionsDopamine synthesisDopamine productionMouse modelIncreased renal dopamine and acute renal adaptation to a high-phosphate diet
Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S. Increased renal dopamine and acute renal adaptation to a high-phosphate diet. American Journal Of Physiology. Renal Physiology 2011, 300: f1123-f1129. PMID: 21325500, PMCID: PMC3094044, DOI: 10.1152/ajprenal.00744.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnalysis of VarianceAnimalsAromatic Amino Acid Decarboxylase InhibitorsCarbidopaCyclic AMP-Dependent Protein KinasesDopa DecarboxylaseDopamineEnzyme InhibitorsKidneyMaleMiceMice, Inbred C57BLMonoamine OxidasePhosphorus, DietaryProtein Kinase CRatsRats, Sprague-DawleySignal TransductionTime FactorsUp-RegulationConceptsHigh-phosphate dietLow-phosphate dietPhosphate excretionDopamine contentRenal dopamine receptorsRenal phosphate excretionRenal tubular reabsorptionTreatment of ratsMarkers of activationRole of dopamineRenal dopamineUrinary excretionTubular reabsorptionRenal adaptationTwo- to threefold increaseAcute increaseMonoamine oxidase ADopamine receptorsDopamine synthesisImpaired adaptation
2010
Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ. Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males. Psychopharmacology 2010, 211: 187-195. PMID: 20495788, PMCID: PMC2892070, DOI: 10.1007/s00213-010-1880-1.Peer-Reviewed Original ResearchConceptsDA synthesisHealthy individualsParkinson's diseaseMale subjectsPlacebo-controlled crossover designCertain psychiatric disordersPunishment processingDA depletionDopamine synthesisHealthy femalesPsychiatric disordersCrossover designFemale subjectsDiseaseNeurotransmitter dopamineGender biasesReward processingThree-way interactionReversal learningSubjectsDepletion procedurePunishment predictionGender differencesSignificant improvement
1997
Dopamine Synthesis, Uptake, Metabolism, and Receptors: Relevance to Gene Therapy of Parkinson's Disease
Elsworth J, Roth R. Dopamine Synthesis, Uptake, Metabolism, and Receptors: Relevance to Gene Therapy of Parkinson's Disease. Experimental Neurology 1997, 144: 4-9. PMID: 9126143, DOI: 10.1006/exnr.1996.6379.Peer-Reviewed Original Research
1990
Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis
Tam S, Elsworth J, Bradberry C, Roth R. Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis. Journal Of Neural Transmission 1990, 81: 97-110. PMID: 2363911, DOI: 10.1007/bf01245830.Peer-Reviewed Original ResearchConceptsMesoprefrontal DA neuronsDA neuronsTyrosine administrationDA levelsCingulate cortexPrefrontal cortexTyrosine hydroxylationAnxiogenic β-carbolineDA metabolite levelsDA terminal fieldsEndogenous DA levelsMesocortical DA neuronsMesocortical dopamine neuronsVivo tyrosine hydroxylationMidbrain DA neuronsTyrosine hydroxylase activityTransmitter outflowDA metabolitesDA synthesisDopamine neuronsFG 7142Dopamine synthesisTerminal fieldsTyrosine availabilityHigh doses
1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 814-822. PMID: 2974120, DOI: 10.1016/s0026-895x(25)10132-6.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1983
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
Grace A, Bunney B. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization. Neuroscience 1983, 10: 301-315. PMID: 6633863, DOI: 10.1016/0306-4522(83)90135-5.Peer-Reviewed Original ResearchConceptsAction potentialsDopamine neuronsDopamine cellsGlyoxylic acid-induced catecholamine fluorescenceInput resistanceDopamine synthesizing enzymePostsynaptic target areasIntracellular dopamine contentNigral dopamine cellsPossible modulatory effectDopamine-containing cellsIntracellular dopamine concentrationSame inhibitory effectHigh input resistanceInitial segmentAntidromic activationDopaminergic neuronsDopamine contentIntracellular recordingsDopamine synthesisCaudate nucleusElectrophysiological characteristicsTyrosine hydroxylaseCatecholamine fluorescenceModulatory effects
1975
Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics.
Bunney B, Roth R, Aghajanian G. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications 1975, 1: 349-58. PMID: 1224004.Peer-Reviewed Original ResearchConceptsEffects of molindoneCentral dopaminergic neuronal activityExtracellular single-unit recordingsLow intravenous dosesDopaminergic neuronal activityDA neuron activityMost antipsychotic drugsBaseline firing rateSingle-unit recordingsDA metabolismDA neuronsIntravenous dosesClassical neurolepticsDopaminergic neuronsOlfactory tubercleDA cellsAntipsychotic drugsD-amphetamineInduced depressionRat midbrainDopamine synthesisNeuronal activityUnit recordingsNeuron activityMolindone
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