2007
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132
Zafar K, Inayat‐Hussain S, Ross D. A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. Journal Of Neurochemistry 2007, 102: 913-921. PMID: 17504267, DOI: 10.1111/j.1471-4159.2007.04637.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsApoptosisCaspasesCell Line, TransformedCysteine Proteinase InhibitorsDopamineDose-Response Relationship, DrugEnzyme ActivationLeupeptinsMesencephalonNerve DegenerationNeuronsOxidative StressParkinson DiseaseProteasome Endopeptidase ComplexRatsReactive Oxygen SpeciesSubstantia NigraConceptsN-acetylcysteineN27 cellsParkinson's diseaseProteasomal inhibitionAbility of dopamineCell deathCaspase-9Dopaminergic neuronsDopaminergic cellsMesencephalic cellsDA treatmentConcentration-dependent apoptosisMG132-induced apoptosisCaspase-dependent apoptosisDiseaseSelective lossMitochondrial membrane potential lossReactive oxygen speciesDopamineCaspase-3Membrane potential lossApoptosisInhibitionQuinoid metabolitesCaspase-2
2002
G protein-coupled receptor kinase 4 gene variants in human essential hypertension
Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown NJ, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3872-3877. PMID: 11904438, PMCID: PMC122616, DOI: 10.1073/pnas.062694599.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBody WeightCells, CulturedCHO CellsCricetinaeCyclic AMPFemaleG-Protein-Coupled Receptor Kinase 4Heart RateHeterotrimeric GTP-Binding ProteinsHumansHypertensionImmunohistochemistryKidney Function TestsKidney Tubules, ProximalMaleMiceMice, TransgenicOrgan SizePolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D1Signal TransductionConceptsHuman essential hypertensionEssential hypertensionGenetic hypertensionProximal tubulesG-protein-coupled receptor kinase activityEnzyme complexUrinary sodium excretionRenal dopaminergic systemG protein-coupled receptor kinasesProtein-coupled receptor kinasesWild-type geneAbility of dopamineRenal proximal tubulesReceptor kinase activitySodium excretionDopaminergic actionsHypotensive effectChinese hamster ovary cellsDopamine receptorsDopaminergic systemHypertensionLike agonistsElectrolyte balanceTransgenic miceHamster ovary cells
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