A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132
Zafar K, Inayat‐Hussain S, Ross D. A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. Journal Of Neurochemistry 2007, 102: 913-921. PMID: 17504267, DOI: 10.1111/j.1471-4159.2007.04637.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsApoptosisCaspasesCell Line, TransformedCysteine Proteinase InhibitorsDopamineDose-Response Relationship, DrugEnzyme ActivationLeupeptinsMesencephalonNerve DegenerationNeuronsOxidative StressParkinson DiseaseProteasome Endopeptidase ComplexRatsReactive Oxygen SpeciesSubstantia NigraConceptsN-acetylcysteineN27 cellsParkinson's diseaseProteasomal inhibitionAbility of dopamineCell deathCaspase-9Dopaminergic neuronsDopaminergic cellsMesencephalic cellsDA treatmentConcentration-dependent apoptosisMG132-induced apoptosisCaspase-dependent apoptosisDiseaseSelective lossMitochondrial membrane potential lossReactive oxygen speciesDopamineCaspase-3Membrane potential lossApoptosisInhibitionQuinoid metabolitesCaspase-2
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