2019
OR13-3 Effects of Iron Isomaltoside versus Ferric Carboxymaltose on Hormonal Control of Phosphate Homeostasis: The PHOSPHARE-IDA04/05 Randomized Controlled Trials
Wolf M, Rubin J, Achebe M, Econs M, Peacock M, Imel E, Thomsen L, Carpenter T, Weber T, Zoller H. OR13-3 Effects of Iron Isomaltoside versus Ferric Carboxymaltose on Hormonal Control of Phosphate Homeostasis: The PHOSPHARE-IDA04/05 Randomized Controlled Trials. Journal Of The Endocrine Society 2019, 3: or13-3. PMCID: PMC6554827, DOI: 10.1210/js.2019-or13-3.Peer-Reviewed Original ResearchIron deficiency anemiaPg/mLFerric carboxymaltoseIron isomaltosideVitamin DIntact FGF23Day 1Day 35Bone turnoverPhosphate excretionIIM groupCorrection of IDADay 8Urinary fractional phosphate excretionBone-specific alkaline phosphataseFractional phosphate excretionNew intravenous iron preparationsIncidence of hypophosphatemiaSevere hypersensitivity reactionsGrowth factor 23Intravenous iron preparationsRenal phosphate excretionRandomized Controlled TrialsRenal phosphate wastingSpecific alkaline phosphatase
2012
FGF23 and Syndromes of Abnormal Renal Phosphate Handling
Bergwitz C, Jüppner H. FGF23 and Syndromes of Abnormal Renal Phosphate Handling. Advances In Experimental Medicine And Biology 2012, 728: 41-64. PMID: 22396161, PMCID: PMC5234086, DOI: 10.1007/978-1-4614-0887-1_3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLoss-of-function mutationsParathyroid hormoneAutosomal dominant hypophosphatemic ricketsDentin matrix protein 1Ecto-nucleotide pyrophosphatase/phosphodiesterase 1O-glycosylation of FGF23Hypophosphatemic ricketsAbnormal renal phosphate handlingImpaired O-glycosylationFibroblast growth factor 23Hormonal bone-parathyroid-kidney axisGrowth factor 23Serum phosphate levelsRenal phosphate excretionRenal phosphate handlingFamilial hyperphosphatemic tumoral calcinosisSodium-phosphate cotransporters NaPi-IIaHereditary hypophosphatemic ricketsHyperphosphatemic tumoral calcinosisIncreased serum phosphate levelsFunction mutationsPhosphate-regulating geneRare genetic disorderCotransporter NaPi-IIaDominant hypophosphatemic rickets
2011
Increased renal dopamine and acute renal adaptation to a high-phosphate diet
Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S. Increased renal dopamine and acute renal adaptation to a high-phosphate diet. American Journal Of Physiology. Renal Physiology 2011, 300: f1123-f1129. PMID: 21325500, PMCID: PMC3094044, DOI: 10.1152/ajprenal.00744.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnalysis of VarianceAnimalsAromatic Amino Acid Decarboxylase InhibitorsCarbidopaCyclic AMP-Dependent Protein KinasesDopa DecarboxylaseDopamineEnzyme InhibitorsKidneyMaleMiceMice, Inbred C57BLMonoamine OxidasePhosphorus, DietaryProtein Kinase CRatsRats, Sprague-DawleySignal TransductionTime FactorsUp-RegulationConceptsHigh-phosphate dietLow-phosphate dietPhosphate excretionDopamine contentRenal dopamine receptorsRenal phosphate excretionRenal tubular reabsorptionTreatment of ratsMarkers of activationRole of dopamineRenal dopamineUrinary excretionTubular reabsorptionRenal adaptationTwo- to threefold increaseAcute increaseMonoamine oxidase ADopamine receptorsDopamine synthesisImpaired adaptation
2010
Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23
Bergwitz C, Jüppner H. Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23. Annual Review Of Medicine 2010, 61: 91-104. PMID: 20059333, PMCID: PMC4777331, DOI: 10.1146/annurev.med.051308.111339.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParathyroid hormoneDentin matrix protein 1Regulation of phosphate homeostasisVitamin DPhosphate homeostasisFibroblast growth factor 23Serum phosphorus levelsGrowth factor 23Renal phosphate excretionSecretion of FGF23Secretion of parathyroid hormoneSodium-phosphate cotransporters NaPi-IIaCotransporter NaPi-IIaIncreases renal phosphate excretionGenetically engineered miceRegulation of calcium homeostasisHomologies to endopeptidasesKidney axisMatrix protein 1Sodium-phosphate cotransporter NaPi-IIaFactor 23Serum phosphorusPhosphate excretionParathyroid glandsHormonal bone-parathyroid-kidney axis
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