Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes
Jiang S, Messina J. Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes. AJP Gastrointestinal And Liver Physiology 2011, 301: g454-g463. PMID: 21680774, PMCID: PMC3174535, DOI: 10.1152/ajpgi.00148.2011.Peer-Reviewed Original ResearchConceptsHepatic Insulin SignalingInsulin signalingHepatic insulin resistanceJNK1 kinasesImpairment of hepatic insulin signalingExpression of dominant-negative JNK1Phosphorylation of insulin receptor substrate 1Serine phosphorylation of insulin receptor substrate 1C-JunInsulin receptor substrate 1Dominant-negative JNK1C-Jun NH(2)-terminal kinaseC-Jun NH2-terminal kinaseDevelopment of hepatic insulin resistanceIncreased serine phosphorylationSerine kinaseInsulin resistanceSubstrate 1Molecular mechanismsKinaseCritical illnessIKKAssociated with increased mortalityDevelopment of type 2 diabetesJNK1
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply