2023
Master transcription factor reprograming unleashes selective translation promoting castration resistance and immune evasion in lethal prostate cancer.
Santasusagna S, Zhu S, Jawalagatti V, Carceles-Cordon M, Ertel A, Garcia-Longarte S, Song W, Fujiwara N, Li P, Mendizabal I, Petrylak D, Kelly W, Reddy E, Wang L, Schiewer M, Lujambio A, Karnes J, Knudsen K, Cordon-Cardo C, Dong H, Huang H, Carracedo A, Hoshida Y, Rodriguez-Bravo V, Domingo-Domenech J. Master transcription factor reprograming unleashes selective translation promoting castration resistance and immune evasion in lethal prostate cancer. Cancer Discovery 2023, 13: 2584-2609. PMID: 37676710, PMCID: PMC10714140, DOI: 10.1158/2159-8290.cd-23-0306.Peer-Reviewed Original ResearchConceptsLethal prostate cancerProstate cancerCastration resistanceImmune evasionPharmacologic targetingAnti-PD-1 therapyMajor histocompatibility complex IDeprivation therapyMicrophthalmia transcription factorAndrogen receptorPreclinical modelsTherapeutic strategiesCancerTherapyDruggable mechanismMaster transcription factorTranscription factorsKey mRNAsSpecific mRNAsMRNAFactor 3bEvasionSelected ArticlesTargetingTumors
2018
Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice
Michael HT, Graff-Cherry C, Chin S, Rauck C, Habtemichael AD, Bunda P, Smith T, Campos MM, Bharti K, Arnheiter H, Merlino G, Day CP. Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice. Investigative Ophthalmology & Visual Science 2018, 59: 6067-6073. PMID: 30590377, PMCID: PMC6314104, DOI: 10.1167/iovs.18-25186.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternChoroidEctopic Gene ExpressionEmbryonic DevelopmentFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGenotyping TechniquesImmunohistochemistryIntramolecular OxidoreductasesIrisMaleMelanocytesMiceMice, Inbred C57BLMice, TransgenicMicrophthalmia-Associated Transcription FactorMicrophthalmosRetinal Pigment EpitheliumReverse Transcriptase Polymerase Chain ReactionSkinConceptsMicrophthalmia transcription factorMITF-M expressionEctopic expressionEpithelium gene expressionRetinal dysplasiaNew mouse lineMouse eyeRetinal structureCutaneous melanocytesRPE structureUveal melanocytesRPE functionMiceMouse linesComplete deficiencyPigmentary genesInducible ectopic expressionMelanocytesMITF isoformsIris melanocytesMicrophthalmiaPhenotypic abnormalitiesEyesMITFPartial rescue
2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumors
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