2023
Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation
Lyu F, Burzynski C, Fang Y, Tal A, Chen A, Kisa J, Agrawal K, Kluger Y, Taylor H, Tal R. Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation. JCI Insight 2023, 8: e172216. PMID: 37815869, PMCID: PMC10721256, DOI: 10.1172/jci.insight.172216.Peer-Reviewed Original ResearchConceptsCXCR4-deficient micePlacental vascular developmentNK cellsCxcr4 deletionNormal placental vascular developmentPlacental developmentNK cell dysfunctionNK cell expressionNK cell infiltrationNK cell functionRole of CXCR4Cell functionMaternal-fetal interfaceImmune cell functionEarly placental developmentWt CXCR4Immune dysregulationVascular developmentGiant cell layerImmune toleranceCXCR4 expressionPeripheral bloodPregnancy failureCell infiltrationPregnancy loss
2022
Chemokine C-X-C receptor 4 mediates recruitment of bone marrow-derived nonhematopoietic and immune cells to the pregnant uterus
Fang YY, Lyu F, Abuwala N, Tal A, Chen AY, Taylor HS, Tal R. Chemokine C-X-C receptor 4 mediates recruitment of bone marrow-derived nonhematopoietic and immune cells to the pregnant uterus. Biology Of Reproduction 2022, 106: 1083-1097. PMID: 35134114, PMCID: PMC9198949, DOI: 10.1093/biolre/ioac029.Peer-Reviewed Original ResearchConceptsBone marrow-derived progenitor cellsBM-derived cellsPregnant deciduaPregnant uterusMarrow-derived progenitor cellsC receptor 4Pregnancy-induced increaseRecruitment of boneProgenitor cellsWild-type C57BL/6CXCL12-CXCR4 axisStem/progenitor cellsTamoxifen-inducible CreNK cellsControl miceBM donorsCXCR4 expressionTransgenic GFP miceImmune cellsReceptor 4Nonpregnant uterusChemokine CCXCL12 ligandFemale recipientsSuccessful implantation
2021
Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration
Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.Peer-Reviewed Original ResearchConceptsEndometriosis lesionsEpithelial compartmentLesion numberDisruption of CXCR4Intraepithelial lymphocyte infiltrationAdult female miceLoss of CXCR4CXCL12-CXCR4 axisTotal lesion areaProgesterone receptor promoterEndometriosis inductionLymphocyte infiltrationCXCR4 expressionFemale miceHost miceControl lesionsProestrus stageEpithelial proliferationImmune evasionCXCR4LesionsTherapeutic potentialLesion areaReduces ProliferationEpithelial cells
2020
CXCL12 Attracts Bone Marrow-Derived Cells to Uterine Leiomyomas
Moridi I, Mamillapalli R, Kodaman PH, Habata S, Dang T, Taylor HS. CXCL12 Attracts Bone Marrow-Derived Cells to Uterine Leiomyomas. Reproductive Sciences 2020, 27: 1724-1730. PMID: 32020550, DOI: 10.1007/s43032-020-00166-x.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsExpression of CXCL12Uterine leiomyomaLeiomyoma growthCommon benign gynecologic tumorsNormal myometriumEngraftment of BMDCsBenign gynecologic tumorsCXCR4 antagonist AMD3100Myometrium of womenStem/progenitor cellsUterine myomaGynecologic tumorsMyoma cellsAntagonist AMD3100CXCR4 expressionControl myometriumReproductive ageUterine diseaseMouse uterusCurrent evidenceLeiomyomaBone marrowMyometrium
2016
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nature Communications 2016, 7: 11268. PMID: 27068353, PMCID: PMC4832062, DOI: 10.1038/ncomms11268.Peer-Reviewed Original ResearchConceptsRetinal vascular defectsMiR-139-5pG protein-coupled receptorsVascular defectsGPCR crosstalkProtein-coupled receptorsVascular developmentCXCR4 expressionCXCR4 axisCXCR4 signalingDownstream signaling cascadesVascular phenotypePharmacological inhibitionVascular maturationDeficient stateApelinAPLNRLigand-receptor pairsSignaling cascadesInhibitionCXCR4MiceReceptors
2015
Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression
Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Research 2015, 15: 14-22. PMID: 25957946, PMCID: PMC5001152, DOI: 10.1016/j.scr.2015.04.004.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsBone marrow cellsEndometrial stromal cellsCXCR4 expressionEndometrial cellsBM cellsCXCL12/CXCR4 expressionStromal cellsBone marrow-derived stem cellsMarrow-derived stem cellsHuman endometrial cellsStem cellsEndometrial disordersCXCL12 receptorCXCR4 antagonistCXCL12 expressionChemokine CXCL12Uterine endometriumCells engraftBone marrowEndometriumMarrow cellsStem cell migrationCXCR4CXCL12
2014
Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors
Yuan A, Lee Y, Choi U, Moeckel G, Karihaloo A. Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors. American Journal Of Physiology. Renal Physiology 2014, 308: f459-f472. PMID: 25537742, PMCID: PMC4346747, DOI: 10.1152/ajprenal.00146.2014.Peer-Reviewed Original ResearchConceptsUnilateral ureteral obstructionCXCR4 expressionKidney fibrosisChemokine receptorsFibrotic responseSmooth muscle actin levelsG protein-coupled chemokine receptorsGrowth factorChronic kidney inflammationProgressive tissue injuryChronic kidney diseaseHigh CXCR4 expressionTGF-β1 levelsEffector cell typesProgression of fibrosisScarring/fibrosisFinal common pathwayPlatelet-derived growth factorRenal injuryKidney inflammationObstructed kidneysBone morphogenetic protein-7Renal fibrosisUreteral obstructionKidney disease
2010
Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst A, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis & Rheumatism 2010, 62: 3436-3446. PMID: 20722038, PMCID: PMC8972909, DOI: 10.1002/art.27685.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus nephritisSLE patientsCXCR4 expressionPeripheral blood leukocytesNeuropsychiatric SLEB cellsLupus erythematosusBlood leukocytesSLE Disease Activity Index (SLEDAI) scoreClasses of LNDisease activity index scoreSeverity of LNNeuropsychiatric systemic lupus erythematosusCentral nervous system involvementClass IV lupus nephritisActive neuropsychiatric systemic lupus erythematosusCXCR4/CXCL12 axisAnti-CXCL12 antibodyActivity index scoreNervous system involvementSubset of patientsMurine lupus modelsGlomeruli of kidneysPotential therapeutic target
2009
CXCR4 Expression in Early Breast Cancer and Risk of Distant Recurrence
Andre F, Xia W, Conforti R, Wei Y, Boulet T, Tomasic G, Spielmann M, Zoubir M, Berrada N, Arriagada R, Hortobagyi GN, Hung M, Pusztai L, Delaloge S, Michiels S, Cristofanilli M. CXCR4 Expression in Early Breast Cancer and Risk of Distant Recurrence. The Oncologist 2009, 14: 1182-1188. PMID: 19939894, DOI: 10.1634/theoncologist.2009-0161.Peer-Reviewed Original ResearchConceptsPrimary breast tumorsCXCR4 expressionBone metastasesBreast tumorsClinical characteristicsDistant metastasisPrognostic valueHigh riskLigand stromal cell-derived factor-1Stromal cell-derived factor-1Cell-derived factor-1Bone-targeted agentsEarly breast cancerProspective clinical trialsCox regression modelNovel adjuvant strategyExpression of CXCR4Chemokine receptor 4Early metastatic processOccurrence of metastasesSpecific organ sitesCXCR4 tumorsDistant recurrenceOverall survivalAdjuvant strategiesCXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus
Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus. The Journal Of Immunology 2009, 182: 4448-4458. PMID: 19299746, PMCID: PMC2946082, DOI: 10.4049/jimmunol.0801920.Peer-Reviewed Original ResearchConceptsMurine modelIncreased CXCR4 expressionPathogenesis of lupusB cell subsetsPromising therapeutic targetCXCR4/CXCL12Multiple murine modelsB cell survivalLupus nephritisActive nephritisSerum autoantibodiesCell subsetsCXCR4 expressionInflammatory cytokinesNephritic kidneysOrgan diseasePathogenic rolePlasma cellsLeukocyte traffickingTherapeutic targetLupusPeptide antagonistCXCR4Surface moleculesNephritis
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