2023
Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
Sieckmann T, Schley G, Ögel N, Kelterborn S, Boivin F, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Lichtenberger F, Breiderhoff T, Knauf F, Rosenberger C, Aigner F, Schmidt-Ott K, Scholz H, Kirschner K. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury. Kidney International 2023, 104: 90-107. PMID: 37121432, DOI: 10.1016/j.kint.2023.04.005.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryKidney injuryKidney pathologyExperimental kidney injuryChronic kidney injuryUnilateral ureteral obstructionForms of injuryPolyamine synthesisCyclosporine treatmentArterial hypertensionKidney transplantationUreteral obstructionKidney levelsTissue injuryTubular castsHealthy kidneysHomeostasis contributesInjuryKidneyExperimental modelKidney cell linePutrescine contentReduced expressionGene expression changesTransplantationPredicting Septic Shock After Emergent Ureteral Stenting in Stone-Related Obstruction and Presumed Infections
Lee J, Kottooran C, Hinojosa-Gonzalez D, Yaghoubian A, Uppaluri N, Hanson K, Borofsky M, Eisner B. Predicting Septic Shock After Emergent Ureteral Stenting in Stone-Related Obstruction and Presumed Infections. Journal Of Endourology 2023, 37: 127-132. PMID: 36136910, DOI: 10.1089/end.2022.0200.Peer-Reviewed Original ResearchConceptsUrinary tract infectionSeptic shockSIRS criteriaTract infectionsQuick Sequential Organ Failure Assessment (qSOFA) scoreSequential Organ Failure Assessment scoreSystemic inflammatory response syndrome criteriaConcomitant urinary tract infectionIntensive care unit admissionOrgan Failure Assessment scoreSequential Organ Failure AssessmentPostoperative septic shockCare unit admissionOrgan Failure AssessmentUnilateral ureteral obstructionUreteral stent placementPresumed infectionsVasopressor requirementUnit admissionPrimary endpointSyndrome criteriaConsecutive patientsRetrospective reviewUreteral obstructionStent placement
2021
Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis
Jiao B, An C, Tran M, Du H, Wang P, Zhou D, Wang Y. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Frontiers In Immunology 2021, 12: 735014. PMID: 34512669, PMCID: PMC8426438, DOI: 10.3389/fimmu.2021.735014.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseFolic acid administrationUnilateral ureteral obstructionRenal fibrosisM2 macrophage polarizationMacrophage polarizationUreteral obstructionFibroblast activationAcid administrationKidney functionKidney diseaseKidney fibrosisPreserves kidney functionSTAT6 activationVehicle-treated miceFolic acid nephropathyExperimental murine modelAlternative macrophage polarizationWild-type miceNovel therapeutic approachesExtracellular matrix protein productionSTAT6 inhibitorMatrix protein productionAS1517499Effective therapy
2020
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA. Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses. The Journal Of Immunology 2020, 205: 377-386. PMID: 32522836, PMCID: PMC7368461, DOI: 10.4049/jimmunol.1901463.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUnilateral ureteral obstructionIL-17AIL-27RαIL-27Ureteral obstructionKidney diseaseIL-27 actsImmune cell infiltratesCytokine IL-27Day of surgeryImmune-mediated pathologyTubular epithelial cellsDegree of injuryFibrosis AssociatedKidney injuryTh17 cellsTh17 responsesCell infiltrateSerum levelsInflammatory cascadeRenal fibrosisIL-17RAImmune cellsChemokine mRNA
2019
Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats
Wang L, Ren X, Tian XF, Cheng XL, Zhao YY, Li QY, Duan ZY, Tian LF, Chen Z, Lu JM, Liang XY, Zhao YF, Fu RG. Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats. Biomedicine & Pharmacotherapy 2019, 117: 109172. PMID: 31261028, DOI: 10.1016/j.biopha.2019.109172.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsbeta CateninBiphenyl CompoundsCytokinesFibrosisGene Expression RegulationKidney DiseasesMacrophages, PeritonealMaleModels, BiologicalPhenotypePhenylpropionatesProtective AgentsRats, Sprague-DawleyReceptors, G-Protein-CoupledSignal TransductionTransforming Growth Factor beta1Ureteral ObstructionVimentinConceptsRenal interstitial fibrosisUnilateral ureteral obstructionInterstitial fibrosisUreteral obstructionProtective effectFree fatty acid receptor GPR120Fatty acid receptor GPR120Unilateral ureteral obstruction operationPeritoneal macrophagesAbnormal expressionExpression of CD206M2 phenotype macrophagesTumor necrosis factorEpithelial-mesenchymal transitionAutologous administrationReceptor GPR120UUO ratsInterleukin-6Intrarenal injectionArginase-1Necrosis factorGPR120 agonistM2 phenotypeΑ-SMATGF-β1
2014
Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors
Yuan A, Lee Y, Choi U, Moeckel G, Karihaloo A. Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors. American Journal Of Physiology. Renal Physiology 2014, 308: f459-f472. PMID: 25537742, PMCID: PMC4346747, DOI: 10.1152/ajprenal.00146.2014.Peer-Reviewed Original ResearchConceptsUnilateral ureteral obstructionCXCR4 expressionKidney fibrosisChemokine receptorsFibrotic responseSmooth muscle actin levelsG protein-coupled chemokine receptorsGrowth factorChronic kidney inflammationProgressive tissue injuryChronic kidney diseaseHigh CXCR4 expressionTGF-β1 levelsEffector cell typesProgression of fibrosisScarring/fibrosisFinal common pathwayPlatelet-derived growth factorRenal injuryKidney inflammationObstructed kidneysBone morphogenetic protein-7Renal fibrosisUreteral obstructionKidney disease
2010
Identification and Regulation of Reticulon 4B (Nogo-B) in Renal Tubular Epithelial Cells
Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC. Identification and Regulation of Reticulon 4B (Nogo-B) in Renal Tubular Epithelial Cells. American Journal Of Pathology 2010, 177: 2765-2773. PMID: 20971739, PMCID: PMC2993268, DOI: 10.2353/ajpath.2010.100199.Peer-Reviewed Original ResearchConceptsUnilateral ureteral obstructionAcute tubular necrosisEpithelial cellsRenal tubular epithelial cellsMurine kidneyIschemia/reperfusionMeasurement of fibrosisDistal nephron segmentsRecruitment of macrophagesWild-type miceInflammatory gene expressionTubular epithelial cellsDe novo expressionHuman biopsy specimensRenal injuryTubular necrosisUreteral obstructionWT miceVascular injuryHistological damageBiopsy specimensCortical tubulesDeficient miceMacrophage recruitmentTissue injuryTGF-β Receptor Deletion in the Renal Collecting System Exacerbates Fibrosis
Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. TGF-β Receptor Deletion in the Renal Collecting System Exacerbates Fibrosis. Journal Of The American Society Of Nephrology 2010, 21: 1334-1343. PMID: 20576806, PMCID: PMC2938601, DOI: 10.1681/asn.2010020147.Peer-Reviewed Original ResearchConceptsRenal collecting systemTGF-beta signalingRenal fibrosisReceptor deletionCollecting systemTGF-beta type II receptorUnilateral ureteral obstructionReceptor-mediated functionsRenal interstitial fibroblastsTGF-beta activationType II receptorParadoxic increaseUreteral obstructionII receptorsInterstitial fibroblastsInterstitial cellsFibrosisDuct cellsCollagen synthesisUreteric bud developmentInjuryMiceMatrix productionEnhanced levelsSignalingChronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background
Puri T, Shakaib M, Chang A, Mathew L, Olayinka O, Minto A, Sarav M, Hack B, Quigg R. Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background. American Journal Of Physiology. Renal Physiology 2010, 298: f1024-f1032. PMID: 20089676, PMCID: PMC2853313, DOI: 10.1152/ajprenal.00384.2009.Peer-Reviewed Original ResearchConceptsReversible unilateral ureteral obstructionChronic kidney diseaseUnilateral ureteral obstructionDevelopment of chronic kidney diseaseUreteral obstructionBlood urea nitrogenC57BL/6 miceResistant to chronic kidney diseaseBALB/c miceKidney diseaseModel of chronic kidney diseaseDays of ureteral obstructionRelease of ureteral obstructionModel of renal fibrosisBackground Chronic kidney diseaseProliferative cellular responseResponse to injuryRenal injuryRenal fibrosisRenal architectureObstructionUrea nitrogenMiceC57BL/6Injury
2009
Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction
Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S. Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. Kidney International 2009, 76: 868-876. PMID: 19675527, DOI: 10.1038/ki.2009.304.Peer-Reviewed Original ResearchConceptsUreteral obstructionFibrotic responseKnockout miceMet receptorAcute tubular necrosisPlasminogen activator inhibitor-1Unilateral ureteral obstructionTubular cell proliferationActivator inhibitor-1Conditional knockout miceHepatocyte growth factorKidney injuryRenal injuryTubular necrosisFunctional recoveryInterstitial fibrosisCre miceRenal repairNephron injuryControl littermatesObstructionGrowth factorMiceInhibitor-1Injury
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