Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst A, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis & Rheumatism 2010, 62: 3436-3446. PMID: 20722038, PMCID: PMC8972909, DOI: 10.1002/art.27685.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus nephritisSLE patientsCXCR4 expressionPeripheral blood leukocytesNeuropsychiatric SLEB cellsLupus erythematosusBlood leukocytesSLE Disease Activity Index (SLEDAI) scoreClasses of LNDisease activity index scoreSeverity of LNNeuropsychiatric systemic lupus erythematosusCentral nervous system involvementClass IV lupus nephritisActive neuropsychiatric systemic lupus erythematosusCXCR4/CXCL12 axisAnti-CXCL12 antibodyActivity index scoreNervous system involvementSubset of patientsMurine lupus modelsGlomeruli of kidneysPotential therapeutic targetDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells
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