2025
Colorectal adenosquamous carcinoma: clinicopathologic analysis of two large cohorts and literature review confirm poor prognosis and reveal prognostic aspects
Gonzalez R, Horton R, Zhang X, Graham R, Longacre T, Mehrotra A, Allende D, McHugh K, Shia J, Westerhoff M, Srivastava A, Chen W, Vazzano J, Swanson P, Chatterjee D, Cheema H, Ma C, Mannan R, Chetty R, Nowak K, Serra S, Agostini‐Vulaj D, Kazemimood R, Henn P, Kakar S, Choi W, Adeyi O, Jenkins S, Nagtegaal I. Colorectal adenosquamous carcinoma: clinicopathologic analysis of two large cohorts and literature review confirm poor prognosis and reveal prognostic aspects. Histopathology 2025, 86: 1064-1081. PMID: 39887413, DOI: 10.1111/his.15412.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesAdenosquamous carcinomaColorectal adenosquamous carcinomaTumor buddingPoor prognosisMedian time to progressionMeta-analysis of cohortLow tumor buddingTime to progressionMale:female ratioReview of casesIndividual case seriesNodal metastasisRecurrent diseaseSquamous componentPatient ageRecurrence rateAcademic medical centreCase seriesImmunohistochemical featuresPrognostic aspectsClinicopathological analysisFemale ratioFollow-upColorectal cancer
2024
Phase II Trial of Afatinib in Patients With EGFR-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A
Gettinger S, Song Z, Reckamp K, Moscow J, Gray R, Wang V, McShane L, Rubinstein L, Patton D, Williams P, Hamilton S, Kong X, Tricoli J, Conley B, Arteaga C, Harris L, O'Dwyer P, Chen A, Flaherty K. Phase II Trial of Afatinib in Patients With EGFR-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A. JCO Precision Oncology 2024, 8: e2300725. PMID: 38986051, DOI: 10.1200/po.23.00725.Peer-Reviewed Original ResearchConceptsProgression-free survivalTyrosine kinase inhibitorsEGFR tyrosine kinase inhibitorsNCI-MATCHLung cancerGlioblastoma multiformeOverall survivalAdvanced non-small cell lung cancerNational Cancer Institute-Molecular AnalysisNon-small cell lung cancerEnd pointsTumor genomic testingTrial primary end pointPhase 2 trialPhase II trialSecondary end pointsPrimary end pointCell lung cancerCohort of patientsMedian OSStable diseaseAdenosquamous carcinomaProtocol therapyPartial responseArm A
2023
GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression
Wang M, Chen P, Cai G. GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. Human Pathology 2023, 135: 93-98. PMID: 36702357, DOI: 10.1016/j.humpath.2023.01.007.Peer-Reviewed Original ResearchConceptsLarge cell carcinomaPrimary lung carcinomaSarcomatoid carcinomaCell carcinomaNapsin ALung carcinomaGATA3 expressionTTF-1Non-small cell carcinomaNon-small cell lung carcinomaPrimary non-small cell lung carcinomasPrimary lung cancerSquamous cell carcinomaPanel of immunostainsCell lung carcinomaExpression of GATA3Whole-slide sectionsTMA casesAdenosquamous carcinomaTumor histologyHistopathologic featuresGATA3 stainingLung cancerP40 expressionTumor origin
2020
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma
Hayashi A, Yavas A, McIntyre C, Ho Y, Erakky A, Wong W, Varghese A, Melchor J, Overholtzer M, O’Reilly E, Klimstra D, Basturk O, Iacobuzio-Donahue C. Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma. Modern Pathology 2020, 33: 1822-1831. PMID: 32350415, PMCID: PMC7452867, DOI: 10.1038/s41379-020-0549-5.Peer-Reviewed Original ResearchConceptsCell-in-cellPancreatic ductal adenocarcinomaDuctal adenocarcinomaClinical correlatesRegulated cell deathPrimary pancreatic ductal adenocarcinomaMultivariate Cox regression analysisConventional pancreatic ductal adenocarcinomaPoorly differentiated adenocarcinomaHuman pancreatic ductal adenocarcinomaCox regression analysisModerately differentiated adenocarcinomaCell competitionEntosisCell deathAdenosquamous carcinomaMolecular mechanismsMYC amplificationMolecular insightsTP53 mutationsLiver metastasesKRAS amplificationImproved survivalPoor prognosisAggressive cancer
2019
Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants
Hutchings D, Jiang Z, Skaro M, Weiss M, Wolfgang C, Makary M, He J, Cameron J, Zheng L, Klimstra D, Brand R, Singhi A, Goggins M, Klein A, Roberts N, Hruban R. Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants. Modern Pathology 2019, 32: 1806-1813. PMID: 31285527, PMCID: PMC7403604, DOI: 10.1038/s41379-019-0317-6.Peer-Reviewed Original ResearchConceptsATM pathogenic variantsIntraductal papillary mucinous neoplasmGermline pathogenic variantsPapillary mucinous neoplasmPancreatic cancerPathogenic variantsHistological subtypesMucinous neoplasmsDuctal adenocarcinomaIncreased risk of pancreatic ductal adenocarcinomaIncipient intraductal papillary mucinous neoplasmsRisk of pancreatic ductal adenocarcinomaSporadic pancreatic cancerGermline genetic testingPancreatic intraepithelial neoplasiaPancreatic cancer patientsNon-invasive precursor lesionsPancreatic ductal adenocarcinomaAdenosquamous carcinomaIntraepithelial neoplasiaPrecursor lesionsChemotherapeutic drugsCancer patientsIncreased riskATM serine/threonine kinase
2017
Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix
Wong S, Hong W, Hui P, Buza N. Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix. International Journal Of Gynecological Pathology 2017, 36: 101-106. PMID: 27362905, DOI: 10.1097/pgp.0000000000000309.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaEpithelial malignanciesPAX8 expressionAdenosquamous carcinomaMajority of SCCsCervical squamous cell carcinomaPossible primary sitesEndometrioid-type tumorsWeak nuclear stainingTissue microarray slidesGynecologic malignanciesEndometrial adenocarcinomaEndometrioid adenocarcinomaMetastatic lesionsEndometrial carcinomaMetastatic sitesUterine cervixCell carcinomaCervical tumorsEndocervical adenocarcinomaDifferential diagnosisPrimary siteAdenocarcinomaCarcinomaMalignancy
2016
Assessment of genomic alterations in adenosquamous carcinoma of the pancreas (ASCOP).
Jordan E, Basturk O, Leach S, Klimstra D, Allen P, Berger M, Askan G, Yu K, O'Reilly E, Lowery M. Assessment of genomic alterations in adenosquamous carcinoma of the pancreas (ASCOP). Journal Of Clinical Oncology 2016, 34: 261-261. DOI: 10.1200/jco.2016.34.4_suppl.261.Peer-Reviewed Original ResearchRecurrence-free intervalOverall survivalMolecular profilingStage IV diseaseNext generation sequencing assayComprehensive molecular profilingAssessment of genomic alterationsCohort of patientsReview clinical characteristicsCopy number aberrationsExocrine pancreatic cancerTargeted deep sequencingMedian OSMedian PFSResected ptsTP53-MUTMedian followAdenosquamous carcinomaIV diseaseLine therapySurgical resectionRare subtypeSquamous componentClinicopathological dataKRAS mutations
2014
The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma
Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo W, Zuo M, Valasek M, Javle M, Wilkinson M, Lu Y. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nature Medicine 2014, 20: 596-598. PMID: 24859531, PMCID: PMC4048332, DOI: 10.1038/nm.3548.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBase SequenceCarcinoma, AdenosquamousGene ComponentsHEK293 CellsHumansImmunohistochemistryIn Situ Nick-End LabelingMolecular Sequence DataMutagenesisMutationNonsense Mediated mRNA DecayPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA HelicasesSequence Analysis, DNATrans-Activators
2010
Squamous Lesions of the Cervix
Chhieng D, Hui P. Squamous Lesions of the Cervix. Current Clinical Pathology 2010, 35-58. DOI: 10.1007/978-1-60761-164-6_3.Peer-Reviewed Original ResearchSquamous cell carcinomaCell carcinomaHPV infectionHigh-risk HPV infectionCervical intraepithelial neoplasia (CIN) 1Low-risk HPV subtypesLow-risk subtypesHigh-grade CINHigh-risk HPVHuman papillomavirus infectionLow-risk groupClear cell carcinomaMinimal deviation adenocarcinomaSquamous papillomaHPV subtypesPapillomavirus infectionAdenosquamous carcinomaCondyloma acuminatumMucinous carcinomaSerous carcinomaSquamous lesionsCervical adenocarcinomaEndometrioid carcinomaNeuroendocrine carcinomaEndocervical adenocarcinoma
2009
Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining
Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-452. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.Peer-Reviewed Original ResearchConceptsCytokeratin 5/6Adenosquamous carcinomaPrimary cutaneous originSubset of casesCutaneous originMetastatic adenocarcinomaAppropriate therapyRare tumorGlandular differentiationCytokeratin 7Such tumorsDiffuse positivityLuminal areaTumorsCarcinomaAggressive behaviorP63StainClose associationAdenocarcinomaTherapyLesionsCasesPositivity
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