2023
GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression
Wang M, Chen P, Cai G. GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. Human Pathology 2023, 135: 93-98. PMID: 36702357, DOI: 10.1016/j.humpath.2023.01.007.Peer-Reviewed Original ResearchConceptsLarge cell carcinomaPrimary lung carcinomaSarcomatoid carcinomaCell carcinomaNapsin ALung carcinomaGATA3 expressionTTF-1Non-small cell carcinomaNon-small cell lung carcinomaPrimary non-small cell lung carcinomasPrimary lung cancerSquamous cell carcinomaPanel of immunostainsCell lung carcinomaExpression of GATA3Whole-slide sectionsTMA casesAdenosquamous carcinomaTumor histologyHistopathologic featuresGATA3 stainingLung cancerP40 expressionTumor origin
2021
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
Ding R, Chen P, Rajendran B, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong A, Valecha M, Yang E, Su S, Choi T, Liu S, Chan K, Yang L, Wu J, Miao K, Chen Q, Shim J, Xu X, Deng C. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nature Communications 2021, 12: 3046. PMID: 34031426, PMCID: PMC8144567, DOI: 10.1038/s41467-021-23379-3.Peer-Reviewed Original ResearchConceptsSarcomatoid carcinomaEpithelial-mesenchymal transitionNasopharyngeal carcinomaCarcinoma subtypesNeck cancer typesPatient-derived organoidCRT regimensDistinct molecular featuresMalignant headHigh morbidityTreatment regimensTherapeutic responseEC subtypesPathogenic mechanismsDrug responsivenessEGFR inhibitorsNPC subtypesCancer typesSubtypesCarcinomaPrecision oncologyDrug testsMolecular landscapeRegimensMicrotubule inhibitors
2018
Clinicopathological implications of MET exon 14 mutations in non-small cell lung cancer – A systematic review and meta-analysis
Vuong H, Ho A, Altibi A, Nakazawa T, Katoh R, Kondo T. Clinicopathological implications of MET exon 14 mutations in non-small cell lung cancer – A systematic review and meta-analysis. Lung Cancer 2018, 123: 76-82. PMID: 30089599, DOI: 10.1016/j.lungcan.2018.07.006.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMET exonCell lung cancerAdvanced non-small cell lung cancerLung cancerGenetic eventsOdds ratioPulmonary sarcomatoid carcinomaMeta-analysisConfidence intervalsC-Met inhibitorsRandom-effects modelSarcomatoid carcinomaPrognostic featuresClinicopathological profileDismal survivalTargeted therapyClinicopathological implicationsGenomic alterationsAdvanced ageWeb of ScienceC-MetNon-smokersRare mutationsPatients
2013
Sarcomatoid Lung Carcinomas Show High Levels of Programmed Death Ligand-1 (PD-L1)
Velcheti V, Rimm DL, Schalper KA. Sarcomatoid Lung Carcinomas Show High Levels of Programmed Death Ligand-1 (PD-L1). Journal Of Thoracic Oncology 2013, 8: 803-805. PMID: 23676558, PMCID: PMC3703468, DOI: 10.1097/jto.0b013e318292be18.Peer-Reviewed Original ResearchConceptsDeath ligand 1Sarcomatoid carcinomaCell lung carcinomaLung carcinomaPD-L1PD-1/PD-L1 axisPD-1/PD-L1 pathwayProgrammed Death Ligand 1PD-L1 protein expressionEffector immune responsesPD-L1 axisPD-L1 pathwayLung sarcomatoid carcinomaLung cancer cohortSarcomatoid lung carcinomasLigand 1Mouse monoclonal antibodyDeath-1Lymphocytic infiltrationRare subtypeSuch therapyCancer cohortT cellsCarcinomaTumor types
2005
Clinically Aggressive Solid Pseudopapillary Tumors of the Pancreas
Tang L, Aydin H, Brennan M, Klimstra D. Clinically Aggressive Solid Pseudopapillary Tumors of the Pancreas. The American Journal Of Surgical Pathology 2005, 29: 512-519. PMID: 15767807, DOI: 10.1097/01.pas.0000155159.28530.88.Peer-Reviewed Original ResearchConceptsSolid pseudopapillary tumorCase of solid pseudopapillary tumorLiver metastasesPathological featuresPseudopapillary tumorClinical courseHistological featuresPresence of disseminated diseaseMemorial Sloan-Kettering Cancer CenterSignificant nuclear atypiaUnusual pathological featuresExtensive tumor necrosisAggressive clinical courseDied of diseaseHigh-grade malignant transformationLymph node metastasisDiffuse growth patternImmunohistochemical staining patternsBeta-catenin distributionSarcomatoid carcinomaMetastatic diseaseDisseminated diseaseInitial resectionUnusual neoplasmsTumor necrosis
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