Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1
Kawai T, Cosimi A, Wee S, Houser S, Andrews D, Sogawa H, Phelan J, Boskovic S, Nadazdin O, Abrahamian G, Colvin R, Sach D, Madsen J. Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1. Transplantation 2002, 73: 1757-1764. PMID: 12084998, DOI: 10.1097/00007890-200206150-00011.Peer-Reviewed Original ResearchConceptsDonor bone marrow transplantationKidney allograft recipientsCell-mediated lympholysisBone marrow transplantationAllograft recipientsAllograft survivalMultilineage chimerismCardiac allograftsHematopoietic chimerismMarrow transplantationLong-term acceptancePosttransplant courseIn vitro mixed leukocyte reactionLong-term heart allograft survivalLow-dose total body irradiationInduction of mixed chimerismMHC-mismatched nonhuman primatesDay 0Tolerance to cardiac allograftsImmunological responseMHC-mismatched donorsHeart allograft survivalCardiac allograft survivalHeart allograft recipientsDonor-specific hyporesponsiveness
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