2024
Pharmacologic Inhibition of Transient Receptor Potential Ion Channel Ankyrin 1 Counteracts 2-Chlorobenzalmalononitrile Tear Gas Agent–Induced Cutaneous Injuries
Achanta S, Chintagari N, Balakrishna S, Liu B, Jordt S. Pharmacologic Inhibition of Transient Receptor Potential Ion Channel Ankyrin 1 Counteracts 2-Chlorobenzalmalononitrile Tear Gas Agent–Induced Cutaneous Injuries. Journal Of Pharmacology And Experimental Therapeutics 2024, 388: 613-623. PMID: 38050077, PMCID: PMC10801748, DOI: 10.1124/jpet.123.001666.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsCutaneous injurySkin injuryTRPA1 antagonistTRPA1 inhibitor HC-030031Injury parametersWeek old C57BL/6 male miceInflammatory cytokine levelsC57BL/6 male miceTherapeutic efficacy studiesEffects of CSNeuronal ion channelsMouse ear skinTRPA1 inhibitionAirway obstructionNeurogenic inflammationCytokine levelsHC-030031Severe painPlasma extravasationCS exposureAcute irritationAcute toxic effectsFrequent injuries
2014
A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain
Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain. Current Biology 2014, 24: 473-483. PMID: 24530065, PMCID: PMC3949122, DOI: 10.1016/j.cub.2014.01.013.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesDrug Evaluation, PreclinicalFemaleGene LibraryHumansMolecular Sequence DataNAV1.2 Voltage-Gated Sodium ChannelOocytesPeptidesProtein Structure, TertiarySpider VenomsTransient Receptor Potential ChannelsVoltage-Gated Sodium Channel BlockersXenopus ProteinsConceptsTransient receptor potential ankyrin 1Ion channel modifiersProTxIon channel transient receptor potential ankyrin 1Channel modifiersPeptide toxinsSpecific peptidesIon channelsVoltage-gated sodium channelsContext of painS1-S4Spider venomPotential clinical applicationsTRPA1 antagonistTRPA1 functionAnkyrin 1PeptidesModifiersPeptide antagonistAntagonistSodium channelsPharmacological reagentsReagentsClinical applicationNav1.2
2013
TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic Dermatitis
Oh MH, Oh SY, Lu J, Lou H, Myers AC, Zhu Z, Zheng T. TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic Dermatitis. The Journal Of Immunology 2013, 191: 5371-5382. PMID: 24140646, PMCID: PMC4175413, DOI: 10.4049/jimmunol.1300300.Peer-Reviewed Original ResearchMeSH KeywordsAcetanilidesAnimalsCalcium ChannelsCells, CulturedChronic DiseaseCytokinesDermatitis, AtopicDisease Models, AnimalHumansInterleukin-13Mast CellsMiceMice, Inbred C57BLMice, TransgenicNerve FibersNerve Tissue ProteinsNeuropeptidesPruritusPurinesTh1-Th2 BalanceTransient Receptor Potential ChannelsTRPA1 Cation ChannelUp-RegulationConceptsTransient receptor potential ankyrin 1Chronic atopic dermatitisAtopic dermatitisMast cellsChronic itchTRPA1 expressionAfferent nervesIL-13Nerve fibersInhibition of TRPA1Histamine-independent itchSensory nerve fibersAfferent nerve fibersDorsal root gangliaNovel neural mechanismAD skinAD miceItch pathwaysLesional skinRoot gangliaInflammatory environmentHealthy subjectsSpecific antagonistMouse modelAnkyrin 1
2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2009
TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases
Bessac B, Sivula M, von Hehn C, Caceres A, Escalera J, Jordt S. TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases. The FASEB Journal 2009, 23: 580.11-580.11. DOI: 10.1096/fasebj.23.1_supplement.580.11.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsSame neuronal receptorNoxious effectsTear gasesActivation of Ca2Adverse health effectsNocifensive behaviorAirway irritationCutaneous exposureTRPA1 antagonistSensory neuronsAnkyrin 1Neuronal receptorsPharmacological inhibitionGenetic ablationHealth effectsMembrane currentsFrequent exposureNoxious chemicalsExposureIon channelsSimilar responsesCa2Lacrimation
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