2016
STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
Tian M, Xu J, Lei G, Lombroso PJ, Jackson MF, MacDonald JF. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. Scientific Reports 2016, 6: 36684. PMID: 27857196, PMCID: PMC5114553, DOI: 10.1038/srep36684.Peer-Reviewed Original ResearchConceptsStriatal-enriched protein tyrosine phosphataseFamily of kinasesProtein tyrosine phosphataseM1R stimulationN-methyl-D-aspartate receptorsM1 muscarinic acetylcholine receptorSrc recruitmentTyrosine phosphataseSrc regulationNMDAR functionIntracellular Ca2Step activationMuscarinic acetylcholine receptorsGluN2A subunitGαqAcetylcholine receptorsHigh intracellular Ca2Function of NMDARsSynaptic plasticityPhosphataseNMDAR activationActivationReceptorsRecruitmentCa2
2015
Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex
Che A, Truong DT, Fitch RH, LoTurco JJ. Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Cerebral Cortex 2015, 26: 3705-3718. PMID: 26250775, PMCID: PMC5004750, DOI: 10.1093/cercor/bhv168.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistFunctional synaptic circuitryEvoked glutamate releaseGlutamatergic synaptic transmissionLayer 4 neuronsExcitatory transmissionGlutamate releaseThalamocortical connectionsAmbient glutamateMK-801Receptor antagonistAcute applicationProbability of releaseSomatosensory cortexSynaptic circuitryNMDAR activationSynaptic transmissionSynaptic releaseExcitatory connectivityPostsynaptic NMDARsCortical connectivitySomatosensory neocortexMouse neocortexNMDARNeocortex
2004
Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
Huang H, Bordey A. Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons. Journal Of Neuroscience 2004, 24: 5659-5669. PMID: 15215288, PMCID: PMC6729224, DOI: 10.1523/jneurosci.1338-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid Transport System X-AGAnimalsAntiportersCalciumCerebellumCystineEvoked Potentialsgamma-Aminobutyric AcidGlutamic AcidIn Vitro TechniquesMiceNerve FibersNeural InhibitionNeurogliaPatch-Clamp TechniquesPurkinje CellsReceptors, N-Methyl-D-AspartateReceptors, PresynapticRyanodineSynaptic TransmissionConceptsGlial glutamate transportersMiniature IPSCsPurkinje neuronsGlutamate transportersSpontaneous IPSCsSynaptic inhibitionInhibitory synapsesNMDAR activationWhole-cell patch-clamp recordingsPresynaptic NMDA receptorsPaired-pulse ratioMouse cerebellar slicesNMDA receptor activationPresynaptic NMDA receptor activationPatch-clamp recordingsBergmann glial cellsBeta-benzyloxyaspartic acidAdjacent Purkinje neuronsCystine-glutamate antiporterMIPSC frequencyGABAergic terminalsGABAergic synapsesGlial cellsNMDA receptorsExcitatory synapses
2000
NMDA receptor-mediated control of protein synthesis at developing synapses
Scheetz A, Nairn A, Constantine-Paton M. NMDA receptor-mediated control of protein synthesis at developing synapses. Nature Neuroscience 2000, 3: 211-216. PMID: 10700251, DOI: 10.1038/72915.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCycloheximideElectrophoresis, Gel, Two-DimensionalGlutamic AcidIsoelectric PointMolecular WeightN-MethylaspartatePeptide Elongation Factor 2PhosphorylationPrecipitin TestsProtein BiosynthesisProteinsRatsReceptors, N-Methyl-D-AspartateRetinal Ganglion CellsSuperior ColliculiSynapsesSynaptosomesTime FactorsConceptsNMDAR activationReceptor activationN-methyl-D-aspartate (NMDA) receptor activationActivity-dependent synaptic changesEukaryotic elongation factor 2Receptor-mediated controlSynaptic protein synthesisEEF2 phosphorylationProtein synthesisSuperior colliculiYoung ratsDependent kinase IISynaptic changesLow dosesTotal protein synthesisII synthesisFactor 2Overall protein synthesisActivationElongation factor 2Kinase IIPhosphorylation
1997
N-methyl-d-aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: A role for N-methyl-d-aspartate receptors in controlling protein synthesis
Scheetz A, Nairn A, Constantine-Paton M. N-methyl-d-aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: A role for N-methyl-d-aspartate receptors in controlling protein synthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 14770-14775. PMID: 9405688, PMCID: PMC25112, DOI: 10.1073/pnas.94.26.14770.Peer-Reviewed Original ResearchConceptsEukaryotic translation elongation factor 2EEF2 phosphorylationProtein synthesisTranslation elongation factor 2Elongation factor 2 phosphorylationProtein synthetic machinerySubset of proteinsFactor 2 phosphorylationElongation factor 2Synaptic plasticityNMDAR activationNumerous transcriptsProtein translationReceptor activationNew proteinsTranscriptional alterationsSynthetic machineryPhosphorylationN-methyl-D-aspartate (NMDA) receptor activationDendritic localizationN-methyl-D-aspartate receptorsProtein expressionFactor 2Aspartate receptor activationProtein
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