2014
Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex
Park H, Yu H, Park S, Ahn Y, Kim Y, Kim H. Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex. The International Journal Of Neuropsychopharmacology 2014, 17: 1487-1500. PMID: 24606669, DOI: 10.1017/s1461145714000248.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnalysis of VarianceAnimalsButyric AcidChromatin ImmunoprecipitationDisease Models, AnimalElectroshockFrontal LobeGene Expression RegulationGlial Fibrillary Acidic ProteinHistamine AntagonistsHistone Deacetylase 2MalePhosphopyruvate HydrataseRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateRNA, MessengerSeizuresSignal TransductionConceptsSignaling-related genesHistone deacetylasesHistone modificationsHistone acetylationCalcium/calmodulin-dependent protein kinase II alphaChromatin immunoprecipitation analysisRat frontal cortexEarly growth response 1Transcriptional repressionReceptor-related genesHistone deacetylationH4 proteinN-methyl-D-aspartate 2ATarget genesFrontal cortexImmunoprecipitation analysisElectroconvulsive seizuresGene expressionResponse 1GenesHDAC2 expressionNeuronal cellsECS treatmentClass I HDACsII alpha
2009
Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects
Girgenti MJ, Hunsberger J, Duman CH, Sathyanesan M, Terwilliger R, Newton SS. Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects. Biological Psychiatry 2009, 66: 267-274. PMID: 19185286, DOI: 10.1016/j.biopsych.2008.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBehavior, AnimalBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalElectroshockErythropoietinExploratory BehaviorGene Expression ProfilingGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitLocomotionMaleOligonucleotide Array Sequence AnalysisRatsRats, Sprague-DawleyReceptors, ErythropoietinSeizuresSwimmingConceptsElectroconvulsive seizuresBehavioral effectsNIH testEPO receptorTrophic effectsRobust antidepressant-like effectsAntidepressant-like behavioral effectsBrain-derived neurotrophic factorAntidepressant-like efficacyTranscription factor hypoxiaAntidepressant-like effectsMultiple brain regionsQuantitative polymerase chain reactionExpression of erythropoietinAntidepressant actionAntidepressant effectsPeripheral administrationNeurotrophic factorIntracerebroventricular infusionPolymerase chain reactionTrophic actionNeurotrophic genesAnimal modelsChoroid plexusRegulation of erythropoietin
2001
ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment
Chen A, Shin K, Duman R, Sanacora G. ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment. Journal Of Ect 2001, 17: 27-32. PMID: 11281511, DOI: 10.1097/00124509-200103000-00006.Peer-Reviewed Original ResearchConceptsNeurotrophic factor expressionMossy fiber sproutingBDNF expressionElectroconvulsive seizuresKetamine pretreatmentSeizure durationFiber sproutingDentate gyrusBrain-derived neurotrophic factor (BDNF) expressionFactor expressionChronic electroconvulsive seizureSpecific anesthetic agentsTreatment of depressionNMDA receptor activationMossy fiber pathwayUse of ECTMedial prefrontal cortexTimm histochemistryCortical atrophySeizure intensitySeizure activityMajor depressionNMDA antagonistsNMDA receptorsAnesthetic agents
1995
Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus.
Smith M, Makino S, Altemus M, Michelson D, Hong S, Kvetnansky R, Post R. Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8788-8792. PMID: 7568018, PMCID: PMC41052, DOI: 10.1073/pnas.92.19.8788.Peer-Reviewed Original ResearchConceptsNT-3 mRNA levelsLocus coeruleusNT-3MRNA levelsNeurotrophin-3 (NT-3) mRNA expressionSerotonin-specific reuptake inhibitorsNT-3 levelsNT-3 expressionSurvival of neuronsEffects of stressAntidepressant treatmentElectroconvulsive seizuresChronic treatmentLC neuronsNoradrenergic neuronsReuptake inhibitorsNeurotrophin expressionNeurotrophic factorNeurotrophin-3Norepinephrine uptakeImmobilization stressMood disordersLC functionAntidepressantsClinical depression
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