2015
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra D, Beltran H, Lilenbaum R, Bergsland E. The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap. American Society Of Clinical Oncology Educational Book 2015, 92-103. PMID: 25993147, DOI: 10.14694/edbook_am.2015.35.92.Peer-Reviewed Original ResearchConceptsWD-NETsSite of originPD-NECsNeuroendocrine neoplasmsTreated with platinum-based chemotherapyFeatures of neuroendocrine neoplasmsTreatment of unresectable diseaseSpectrum of neuroendocrine tumorsAggressive clinical coursePlatinum-based chemotherapyFamily of neoplasmsUnresectable diseaseSurgical resectionNeuroendocrine differentiationNeuroendocrine tumorsNeuroendocrine phenotypeClinical courseProstate glandNeoplasia syndromeNon-neoplastic neuroendocrine cellsHistological classificationGenetic alterationsClinical managementAnatomical sitesHistological evidence
2014
Pathology and genetics of pancreatic neoplasms with acinar differentiation
Wood L, Klimstra D. Pathology and genetics of pancreatic neoplasms with acinar differentiation. Seminars In Diagnostic Pathology 2014, 31: 491-497. PMID: 25441307, PMCID: PMC4316670, DOI: 10.1053/j.semdp.2014.08.003.Peer-Reviewed Original ResearchConceptsPancreatic neoplasmsAcinar differentiationAcinar cell carcinomaConventional ductal adenocarcinomaFamily of neoplasmsTherapeutically targetable mutationsAcinar growth patternGranular eosinophilic cytoplasmMolecular dataAcinar neoplasmsGenomic instabilityRare mutationsGenetic alterationsCell carcinomaTargeted mutationEosinophilic cytoplasmPoor prognosisDuctal adenocarcinomaHistological featuresMutationsNeoplastic cellularityNeoplasmsLineage markersUniform nucleiPathological features
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