2021
Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi‐Ethnic Study of Atherosclerosis (MESA)
Lockhart S, Schaich C, Craft S, Sachs B, Rapp S, Jung Y, Whitlow C, Sai K, Cleveland M, Williams B, Burke G, Bertoni A, Hayden K, Hughes T. Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi‐Ethnic Study of Atherosclerosis (MESA). Alzheimer's & Dementia 2021, 18: 551-560. PMID: 34482601, PMCID: PMC8897510, DOI: 10.1002/alz.12429.Peer-Reviewed Original ResearchConceptsFramingham Stroke Risk ProfileAtherosclerotic cardiovascular disease risk estimationMulti-Ethnic Study of AtherosclerosisVascular risk factorsMulti-Ethnic StudyLate-life brain healthRisk factorsCardiovascular disease risk estimatesBaseline vascular risk factorsIncidence of dementiaBaseline cardiovascular risk factorsAssociated with lower cortical thicknessCognitive declineDisease risk estimatesStudy of atherosclerosisWhite matter hyperintensityStroke Risk ProfileCortical thicknessWhite matter hyperintensity volumeCardiovascular risk factorsLower cortical thicknessAssociated with ABRisk estimatesLongitudinal cohortBrain healthAssociation of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration
Moore E, Liu D, Li J, Schimmel S, Cambronero F, Terry J, Nair S, Pechman K, Moore M, Bell S, Beckman J, Gifford K, Hohman T, Blennow K, Zetterberg H, Carr J, Jefferson A. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology 2021, 97: e329-e340. PMID: 34031194, PMCID: PMC8362359, DOI: 10.1212/wnl.0000000000012257.Peer-Reviewed Original ResearchConceptsPulse wave velocitySynaptic dysfunctionYears of ageP-tauParticipants free of strokeMemory and Aging ProjectFramingham Stroke Risk ProfileFree of strokeT-tauAortic pulse wave velocityCommunity-based studyObservational community-based studyAssociation of aortic stiffnessStroke Risk ProfileAging ProjectOlder adultsTau phosphorylationE4 statusAlzheimer's disease pathologyHypertension statusCentral arterial stiffeningHigher aortic pulse wave velocityYKL-40Risk profileCognitive diagnosis
2018
Vascular risk at younger ages most strongly associates with current and future brain volume.
Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S, Beiser AS, DeCarli C. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology 2018, 91: e1479-e1486. PMID: 30232248, PMCID: PMC6202941, DOI: 10.1212/wnl.0000000000006360.Peer-Reviewed Original ResearchConceptsVascular risk factor burdenRisk factor burdenVascular risk factorsLower brain volumeRisk factorsStrength of associationBrain volumeYounger ageAge decadeFramingham Stroke Risk ProfileAge 45 yearsPotential therapeutic effectsStroke Risk ProfileLongitudinal analysisFramingham Heart StudyCross-sectional analysisStroke riskVascular riskDementia riskAge 45Therapeutic effectHeart StudyRisk profileBrain structuresCross-sectional data
2012
Cost-effectiveness of pharmacologic and invasive therapies for stroke prophylaxis in atrial fibrillation
Solomon MD, Ullal AJ, Hoang DD, Freeman JV, Heidenreich P, Turakhia MP. Cost-effectiveness of pharmacologic and invasive therapies for stroke prophylaxis in atrial fibrillation. Journal Of Cardiovascular Medicine 2012, 13: 86-96. PMID: 22193838, DOI: 10.2459/jcm.0b013e32834f23cf.Peer-Reviewed Original ResearchConceptsCost-effectiveness analysisAtrial fibrillationNonpharmacologic therapiesAtrial fibrillation-related strokeVitamin K antagonistsNew pharmacologic therapiesDirect thrombin inhibitorDevice-based therapiesLeft atrial appendageStroke Risk ProfileHealth policy recommendationsPercutaneous ligationStroke prophylaxisK antagonistsStroke preventionPharmacologic therapySurgical ligationAbnormal heart rhythmAntiplatelet agentsProphylaxis strategiesAtrial appendageRight atriumEndovascular implantationInvasive therapySystemic circulation
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