2013
Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers
Bianchini G, Pusztai L, Karn T, Iwamoto T, Rody A, Kelly C, Müller V, Schmidt M, Qi Y, Holtrich U, Becker S, Santarpia L, Fasolo A, Del Conte G, Zambetti M, Sotiriou C, Haibe-Kains B, Symmans WF, Gianni L. Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers. Breast Cancer Research 2013, 15: r86. PMID: 24060333, PMCID: PMC3978752, DOI: 10.1186/bcr3481.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Agents, HormonalBiomarkers, TumorBreast NeoplasmsCell ProliferationChemoradiotherapy, AdjuvantEstrogensFemaleFollow-Up StudiesGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMiddle AgedMitosisNeoplasm GradingNeoplasm MetastasisNeoplasm Recurrence, LocalNeoplasm StagingPrognosisReceptors, EstrogenRiskSignal TransductionTamoxifenConceptsNode-negative tumorsLate relapseNeoadjuvant letrozoleEndocrine therapyEarly relapseNegative tumorsBreast cancerEstrogen receptor-positive breast cancerProliferation markersReceptor-positive breast cancerER-positive breast cancerAdjuvant endocrine therapyAffymetrix gene expression profilesExtended endocrine therapyTamoxifen-treated patientsER-positive patientsGenomic grade indexPositive breast cancerRisk of recurrenceRisk of relapseEstrogen receptor activitySmall independent cohortEstrogen-related genesAdjuvant tamoxifenSystemic therapy
2007
EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor
Hwang C, Giri V, Wilkinson J, Wright C, Wilkinson A, Cooney K, Duckett C. EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. Breast Cancer Research And Treatment 2007, 107: 235-242. PMID: 17453341, DOI: 10.1007/s10549-007-9542-7.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell Line, TumorDisease ProgressionDNA-Binding ProteinsEnhancer Elements, GeneticEnhancer of Zeste Homolog 2 ProteinEstradiolEstrogensHumansMicroscopy, FluorescencePolycomb Repressive Complex 2Polycomb-Group ProteinsProhibitinsReceptors, EstrogenRepressor ProteinsRNA InterferenceSignal TransductionTranscription FactorsTranscription, GeneticConceptsEstrogen-dependent transcriptionCellular differentiationReceptor activityPolycomb group (PcG) proteinsHistone methyltransferase activityDeregulated gene expressionActivity of EZH2Specific target genesNovel binding partnerBreast cancerEstrogen receptor corepressorPcG proteinsHistone modificationsTranscriptional repressionEstrogen-responsive genesTranscriptional corepressorGroup proteinsBreast cancer carcinogenesisZeste homolog 2Binding partnerTranscription factorsTarget genesHuman breast cancerEstrogen receptor activityMethyltransferase activity
1998
Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation
Garabedian M, Rogatsky I, Hittelman A, Knoblauch R, Trowbridge J, Krstic M. Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation. Progress In Gene Expression 1998, 237-260. DOI: 10.1007/978-1-4612-1764-0_9.Peer-Reviewed Original ResearchVersatile posttranslational modificationSignal transduction pathwaysSteroid receptor functionSteroid receptorsTreatment of cellsDNA replicationProtein phosphorylationPosttranslational modificationsTranscription factorsProtein kinaseTransduction pathwaysRegulation of glucocorticoidTranscriptional activityAbsence of hormoneGene expressionIntracellular kinasesPhosphatase activityPhosphorylationEnzymatic activityCell proliferationKinaseReceptor functionEstrogen receptor activityReceptor activityReceptors
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