2020
Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates
Fei C, Mao S, Yan J, Alert R, Stone H, Bassler B, Wingreen N, Košmrlj A. Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7622-7632. PMID: 32193350, PMCID: PMC7148565, DOI: 10.1073/pnas.1919607117.Peer-Reviewed Original ResearchConceptsBiofilm matrix productionBiofilm morphologyBacterial biofilmsAvailability of nutrientsDistinct spatiotemporal patternsImportant physiological consequencesAgar substrateMatrix productionMechanistic insightsPhysiological consequencesBiofilmsSoft substratesSimilar morphologyDiffusion of nutrientsPattern formation processNutrientsBasic mechanismsAgar concentrationEukaryotesMorphological patternsMorphogenesisFundamental determinantsOrganismsGrowthVibrio
2019
Molecular recognition of nucleosomes by binding partners
Kale S, Goncearenco A, Markov Y, Landsman D, Panchenko A. Molecular recognition of nucleosomes by binding partners. Current Opinion In Structural Biology 2019, 56: 164-170. PMID: 30991239, PMCID: PMC6656623, DOI: 10.1016/j.sbi.2019.03.010.Peer-Reviewed Original ResearchConceptsEpigenetic signaling pathwaysChromatin factorsEukaryotic cellsHistone tailsChromatin packingInteraction landscapeLinker DNAMolecular recognitionNucleosomesHistone coreIntrinsic disorderSignaling pathwaysBroad repertoireFurther complexityBasic mechanismsChromatinDNARegulationPathwayRepertoireCellsPartnersTailLandscape
2018
Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future
Sakai C, Ijaz S, Hoffman EJ. Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future. Frontiers In Molecular Neuroscience 2018, 11: 294. PMID: 30210288, PMCID: PMC6123572, DOI: 10.3389/fnmol.2018.00294.Peer-Reviewed Original ResearchGene functionZebrafish modelCRISPR/Cas9 geneSmall-molecule suppressorTransparent embryosZebrafish systemHigh-throughput pharmacological screensNeurodevelopmental disordersGenetic manipulationCas9 geneBehavioral phenotypesLarge progenyFunctional analysisLarval stagesPharmacological screensZebrafishRisk genesGenesModel systemExternal developmentPhenotypeCircuit-level mechanismsBasic mechanismsNeural circuitsNervous system
2016
Endothelial fluid shear stress sensing in vascular health and disease
Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease. Journal Of Clinical Investigation 2016, 126: 821-828. PMID: 26928035, PMCID: PMC4767335, DOI: 10.1172/jci83083.Peer-Reviewed Original ResearchConceptsNormal morphogenesisBiochemical signalsGene expressionSame pathwayFluid shear stressCell behaviorSpecialized mechanismsMorphogenesisPathwayPathological conditionsEndothelial cellsVascular physiologyVascular systemBasic mechanismsRecent advancesFlow signalingSignalingMechanismAdult lifePhysiologyExpression
2015
Functional Circuitry of the Retina
Demb JB, Singer JH. Functional Circuitry of the Retina. Annual Review Of Vision Science 2015, 1: 263-289. PMID: 28532365, PMCID: PMC5749398, DOI: 10.1146/annurev-vision-082114-035334.Peer-Reviewed Original ResearchGanglion cellsImportant model systemCell typesSynaptic excitationMammalian retinaParallel pathwaysMouse retinaModel systemNeural circuitryFunctional circuitryRetinaRetinal computationCellular compositionOutput neuronsBasic mechanismsApparent complexityDynamic balanceCellsStraightforward mechanismSpeciesPathwayInterneuronsMechanismNeuronsBrain
2005
Conduction Abnormalities in Nonischemic Dilated Cardiomyopathy: Basic Mechanisms and Arrhythmic Consequences
Akar FG, Tomaselli GF. Conduction Abnormalities in Nonischemic Dilated Cardiomyopathy: Basic Mechanisms and Arrhythmic Consequences. Trends In Cardiovascular Medicine 2005, 15: 259-264. PMID: 16226681, DOI: 10.1016/j.tcm.2005.08.002.Peer-Reviewed Original ResearchConceptsConduction abnormalitiesVentricular dysfunctionHeart failureMolecular mechanismsLeft ventricular dysfunctionNonischemic heart failureIschemic heart diseaseExtracellular matrixGenesis of arrhythmiasMyocyte excitabilityMechanistic differencesOrgan levelMembrane excitabilityVentricular tachyarrhythmiasDisease etiologyMyocardial infarctionHeart diseaseArrhythmogenic substrateSudden deathArrhythmic consequencesCell couplingAbnormalitiesBasic mechanismsDysfunctionExcitability
2001
Cellular trafficking in trypanosomatids: a new target for therapies?
Costa-Pinto D, Trindade L, McMahon-Pratt D, Traub-Cseko Y. Cellular trafficking in trypanosomatids: a new target for therapies? International Journal For Parasitology 2001, 31: 537-544. PMID: 11334939, DOI: 10.1016/s0020-7519(01)00145-x.Peer-Reviewed Original ResearchConceptsPathogenic trypanosomatidsTrafficking mechanismsLysosomal targetingCellular trafficking mechanismsPlethora of diseasesCellular traffickingTrypanosomatidsTargeting mechanismCysteine proteinasesBiological aspectsNew targetsCurrent knowledgeEfficient vaccineDisease controlTherapyBasic mechanismsTraffickingMechanismTargetParasitesVaccineProteinasesDiseaseTargetingSynesthesia: Strong and Weak
Martino G, Marks L. Synesthesia: Strong and Weak. Current Directions In Psychological Science 2001, 10: 61-65. DOI: 10.1111/1467-8721.00116.Peer-Reviewed Original ResearchCross-modal information processingInformation processingCross-sensory correspondencesPerceptual similarityPerceptual interactionsSensory modalitiesSynesthetic phenomenaPerceptual codingSynesthesiaSimilar underlying mechanismsVivid imagesScientists' understandingProcessingLanguageBasic mechanismsUnderstanding
1998
Molecular Biology of Cerebrovascular Diseases
Gunel M, Awad I, Lifton R. Molecular Biology of Cerebrovascular Diseases. 1998, 163-173. DOI: 10.1007/978-1-4613-9350-4_15.Peer-Reviewed Original ResearchMolecular biologyIdentification of genesCerebrovascular diseaseMolecular geneticsMolecular mechanismsScope of neurosurgeryNovel therapeutic strategiesBiologyNew insightsPathologic angiogenesisInherited predispositionTherapeutic strategiesBasic mechanismsPreclinical diagnosisDiseaseGenesGeneticsMechanismAngiogenesisIschemiaPatientsPathophysiologyPathogenesisNew opportunitiesDiagnosis
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