T1D RELAY

TrialNet is studying the use of rituximab-pvvr and abatacept, one after the other, to learn if using both treatments extends insulin production in people newly diagnosed with type 1 diabetes (T1D).

Previous studies with similar treatments showed people can make more insulin for a longer period of time while receiving either of the treatments. T1D RELAY will study if two treatments consecutively performs better than rituximab-pvvr alone. Researchers will test if those who are also treated with abatacept have better C-peptide levels over time.