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INFORMATION FOR

    Breast, Phase II

    Study to Assess Clinical Activity of Zelenectide Pevedotin in Participants With Advanced Breast Cancer

    What is the purpose of this trial?

    This is a global, multicenter, open-label study that aims to assess the efficacy and safety of zelenectide pevedotin in participants with NECTIN4-amplified recurrent, unresectable, or metastatic breast cancer who have received prior therapy (see inclusion criteria below). The study will comprise of 2 cohorts. Cohort A will include participants with hormone receptor positive/ human epidermal growth factor receptor 2 negative [HR+/HER2-] breast cancer, whereas Cohort B will include participants with triple-negative breast cancer (TNBC).

    Contact Information

    For more information about this study, including how to volunteer, contact Carl Brown

    Help Us Discover!

    You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.

    • Last Updated
      12/17/2025
    • Study HIC
      #2000039480