Sickle Cell Disease | Sickle Cell Disorders, Phase I-II

A Phase 1/2a, First-in-human, Randomized, Double-blinded, Placebo-controlled, Dose-finding Study in Healthy Volunteers and Participants With Sickle Cell Disease to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, pH and Food Effect, and Preliminary Efficacy of BMS-986470

Volunteers
Health Professionals

What is the purpose of this trial?

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, pH and food effect, and preliminary efficacy of BMS-986470 in healthy volunteers and participants with sickle cell disease.

Find out more about who can participate in this trial

Contact Information

For more information about this study, including how to volunteer, contact Jialing Zhang

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.

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Principal Investigator

Cece Calhoun, MD, MPHS, MBA
Assistant Professor of Medicine (Hematology); Medical Director, Sickle Cell Program; Associate Chief of Operations, Smilow Cancer Hospital

Sub-Investigators

Last Updated
08/10/2025
Study HIC
#2000039935