Zhigui Li, PhD
Associate Research ScientistCards
About
Research
Publications
2023
Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice
Roy S, Li Z, Guo Z, Long K, Rehrl S, Tian X, Dong K, Besse W. Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice. Journal Of The American Society Of Nephrology 2023, 34: 1521-1534. PMID: 37332102, PMCID: PMC10482070, DOI: 10.1681/asn.0000000000000164.Peer-Reviewed Original ResearchConceptsUnfolded protein responseAutosomal dominant tubulointerstitial kidney diseaseAutosomal dominant polycystic kidney diseasePolycystin-1Autosomal-dominant polycystic kidney diseaseProtein responseTubulointerstitial kidney diseaseKidney diseaseRenal failureRenal failure in adulthoodPolycystic kidney diseaseUnfolded protein response activationFull-length proteinProteins polycystin-1C-terminal fragmentCystic kidneysSite of maturationCystic kidney dysplasiaKidney disease pathogenesisHeterozygous inactivating mutationsHsp40 cochaperonesEndoplasmic reticulumMouse model studiesConditional allelesDNAJB11KidneyNetwork: using kidney-derived gene expression data to predict and prioritize novel genes involved in kidney disease
Boulogne F, Claus L, Wiersma H, Oelen R, Schukking F, de Klein N, Li S, Westra H, van der Zwaag B, van Reekum F, Sierks D, Schönauer R, Li Z, Bijlsma E, Bos W, Halbritter J, Knoers N, Besse W, Deelen P, Franke L, van Eerde A. KidneyNetwork: using kidney-derived gene expression data to predict and prioritize novel genes involved in kidney disease. European Journal Of Human Genetics 2023, 31: 1300-1308. PMID: 36807342, PMCID: PMC10620423, DOI: 10.1038/s41431-023-01296-x.Peer-Reviewed Original ResearchConceptsCo-expression networkTissue-specific expressionCandidate genesGene functionPhenotypic consequences of genetic variationPathogenic variantsConsequences of genetic variationInterpretation of genetic variantsGenetic causeRare variantsGene-phenotype associationsHereditary kidney diseaseExome sequencing dataDisease-associated genesGene expression dataPlausible candidate genesCandidate gene prioritizationKidney disease phenotypesUnbiased mannerCystic kidneysNovel genesGenetic variationPhenotypic consequencesGene prioritizationSequence data
2020
Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade
Li Z, Mi S, Osagie OI, Ji J, Yang CPH, Schwartz M, Hui P, Huang GS. Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade. 2020 DOI: 10.1101/2020.10.12.331975.Peer-Reviewed Original Research In Press
2016
miR-200 family promotes podocyte differentiation through repression of RSAD2
Li Z, Yin H, Hao S, Wang L, Gao J, Tan X, Yang Z. miR-200 family promotes podocyte differentiation through repression of RSAD2. Scientific Reports 2016, 6: 27105. PMID: 27251424, PMCID: PMC4890021, DOI: 10.1038/srep27105.Peer-Reviewed Original ResearchConceptsMiR-200 familyPodocyte differentiationKidney developmentCell differentiationMiR-200aDifferentiation of podocytesUnderlying molecular mechanismsCellular functionsRNA interferencePostnatal mouse kidneyMolecular mechanismsDifferentiated cellsNovel roleMature podocytesHigher upregulationProtein 2 expressionRSAD2MiR-200bMiR-429DifferentiationPodocyte dedifferentiationRepressionCharacteristic phenotypic featuresPhenotypic featuresMorphological characteristicsAutophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice
Li Z, Hao S, Yin H, Gao J, Yang Z. Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice. Behavioural Brain Research 2016, 305: 265-277. PMID: 26971628, DOI: 10.1016/j.bbr.2016.03.023.Peer-Reviewed Original ResearchMeSH KeywordsAdenineAnimalsAntibiotics, AntineoplasticApoptosisAutophagyBeclin-1Body WeightCognition DisordersDiabetes Mellitus, ExperimentalDisease Models, AnimalEatingExploratory BehaviorHippocampusHypoglycemic AgentsLong-Term PotentiationMaleMaze LearningMiceMice, Inbred C57BLMicrotubule-Associated ProteinsPerforant PathwayRNA, Long NoncodingStreptozocinConceptsDiabetic miceLong-term potentiationCognitive impairmentPaired-pulse facilitationAutophagic inhibitionSynaptic plasticityAutophagic suppressionAnxiety-like behaviorCell deathDiabetes micePVT1 expressionHippocampal neuronsPresynaptic functionDiabetesTerm potentiationCell death analysisMiceSpatial learningImpairmentDeath analysisApoptotic cell deathDepotentiationInhibitionDeathPVT1
2015
Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells
Xu P, Wang H, Li Z, Yang Z. Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells. Life Sciences 2015, 145: 19-26. PMID: 26679104, DOI: 10.1016/j.lfs.2015.12.018.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAβ25-35Alzheimer's diseaseOxidative stressPC12 cellsAβ25-35-induced apoptosisTreatment of ADReactive oxygen speciesPotential neuroprotective effectsEffects of triptolideAβ25-35-induced cytotoxicityDecreased oxidative stressSuperoxide dismutaseProtective functionNeuroprotective effectsImmunohistochemical stainingProtective effectResults of MTTAmyloid betaHerb TripterygiumNervous systemAbnormal depositionCytometry assaysWestern blotTriptolideTriptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway
Xu P, Li Z, Wang H, Zhang X, Yang Z. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway. PLOS ONE 2015, 10: e0142719. PMID: 26554937, PMCID: PMC4640509, DOI: 10.1371/journal.pone.0142719.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAlzheimer's diseaseAβ25-35Differentiated rat pheochromocytoma cell linePC12 cellsLight chain 3 IITreatment of ADCell apoptosisAutophagy pathwayMicrotubule-associated protein light chain 3 IIAβ25-35-induced cytotoxicityEffect of autophagyCell viabilityElevated cell viabilityLevel of autophagyRat pheochromocytoma cell lineTripterygium wilfordii HookActivation of autophagyNeuroprotective effectsNeurological damagePC12 cell apoptosisInhibited cytotoxicityProtective effectPheochromocytoma cell lineAbnormal depositionEffects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury
Wei M, Li Z, Xiao L, Yang Z. Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury. Molecular Immunology 2015, 68: 261-271. PMID: 26364141, DOI: 10.1016/j.molimm.2015.09.002.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Diabetic nephropathyMCP-1 expressionNF-κB inhibitionMCP-1High glucoseReactive oxygen speciesNF-κBSuppression of TLR4NF-κB-dependent signalingChemoattractant protein-1Effects of HGPotential therapeutic targetNF-κB signalingCell viabilityIntracellular reactive oxygen speciesEffects of ROSWestern blot analysisTLR-4Receptor 4Intracellular ROS generationPodocyte injuryPodocyte damageProtective effectCell injuryAutophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level
Wang H, Gao N, Li Z, Yang Z, Zhang T. Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level. Molecular Neurobiology 2015, 53: 1718-1729. PMID: 25724280, DOI: 10.1007/s12035-014-9073-2.Peer-Reviewed Original ResearchConceptsPC12 cellsLC3-II/LC3Western blot assaysCell deathReactive oxygen species levelsSuperoxide dismutase activityMDA levelsOxygen species levelsGeneration of ROSATG-7Autophagy markersBlot assaysIncrease of autophagosomesBeclin-1Oxidative stressDismutase activityROS levelsRapamycinExcessive generationExpression levelsCell viabilityOxidative damageAutophagyMalondialdehydeDeathDifferent Expressions of Large-conductance Ca2+-activated K+ Channels in the Mouse Renal Cortex and Hippocampus During Postnatal Development
Xu P, Li Z, Xuan Q, Yang Z. Different Expressions of Large-conductance Ca2+-activated K+ Channels in the Mouse Renal Cortex and Hippocampus During Postnatal Development. Applied Immunohistochemistry & Molecular Morphology 2015, 23: 146-152. PMID: 25390352, DOI: 10.1097/pai.0000000000000006.Peer-Reviewed Original ResearchConceptsPostnatal developmentRenal corpusclesRenal cortexTime pointsPostnatal day 1Large-conductance Ca2Mouse renal cortexWestern blot analysisVariety of cellsStage IIIStage IVBKCa channelsDay 1HippocampusKidney cortexPathophysiological conditionsCortexProtein levelsBlot analysisCorpusclesPresent studyProminent changesExpressionSpecific roleQuantitation of expression
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