Zafer Akman, MD
Hospital ResidentAbout
Research
Publications
2025
Lipid-Lowering Therapies and Cognition in Older Adults: A Narrative Review and Clinical Considerations
Rossi R, Nouri A, Akman Z, Arya Nezhad S, Damluji A, Nanna M. Lipid-Lowering Therapies and Cognition in Older Adults: A Narrative Review and Clinical Considerations. Current Cardiology Reports 2025, 28: 3. PMID: 41400788, DOI: 10.1007/s11886-025-02329-1.Peer-Reviewed Original ResearchOlder adultsCognitive outcomesGroup of older adultsDiverse group of older adultsCognitive declineMonoclonal antibody PCSK9 inhibitorsCognitionLipid-Lowering TherapyLipid lowering therapyProtective effectLipid lowering agentsClinical considerationsRandomized Controlled TrialsAdultsBempedoic acidStatin usePCSK9 inhibitorsEligible patientsLowering agentsReviewThis reviewObservational studyControlled TrialsClinical practiceNarrative reviewLong-term studiesIntravascular imaging vs. angiography alone to guide percutaneous coronary intervention in older adults: a meta-analysis of randomized controlled trials.
Ezenna C, Ibrahim S, Ismayl M, Murali Krishna M, Chi K, Joseph M, Akman Z, Rossi R, Nouri A, Al Mouslmani M, Damluji A, Goldsweig A, Nanna M. Intravascular imaging vs. angiography alone to guide percutaneous coronary intervention in older adults: a meta-analysis of randomized controlled trials. Coronary Artery Disease 2025 PMID: 41176629, DOI: 10.1097/mca.0000000000001584.Peer-Reviewed Original ResearchPercutaneous coronary interventionMeta-analysis of randomized controlled trialsRandomized Controlled TrialsOlder adultsSubgroup analysisCoronary interventionMeta-analysisIntravascular imagingIntravascular imaging guidanceComplex coronary lesionsPercutaneous coronary intervention outcomesRandom-effects modelMACE reductionHiggins I2 statisticImage guidanceFollow-upAngiographyIntravascular imaging modalitiesCoronary lesionsComplex anatomyI2 statisticLesion complexityControlled TrialsInclusion criteriaImaging modalitiesPercutaneous Coronary Intervention or Medical Therapy for Chronic Total Occlusion in Older Adults
Jamil Y, Dermksian M, El Ghazawi A, Damara F, Augustine A, Walgamage M, Frampton J, Grimshaw A, Park D, Akman Z, Mouslmani M, Nouri A, Babapour G, Rossi R, Kochar A, Curtis J, Tehrani B, Batchelor W, Sherwood M, Damluji A, Nanna M. Percutaneous Coronary Intervention or Medical Therapy for Chronic Total Occlusion in Older Adults. JACC Advances 2025, 4: 102240. PMID: 41165643, DOI: 10.1016/j.jacadv.2025.102240.Peer-Reviewed Original ResearchOlder adultsObservational studyRelative riskOptimal medical therapyQuality of lifeAll-Cause MortalityInclusion of studiesCardiovascular outcomesRandomized trialsPercutaneous coronary interventionCoronary chronic total occlusionScarcity of evidenceMeta-regression analysisRates of myocardial infarctionOlder populationMeta-RegressionSystematic searchOlder individualsChronic total occlusionCoronary interventionCTO-PCIAssociated with reductionsQoLMedical therapyAdultsDirect oral anticoagulants vs. warfarin for left ventricular thrombus: a meta-analysis of randomized controlled trials
Chi K, Lee P, Abdullah A, Kumar S, Ezenna C, Acero L, Krishna M, Akman Z, Lin Y, Damluji A, Nanna M. Direct oral anticoagulants vs. warfarin for left ventricular thrombus: a meta-analysis of randomized controlled trials. European Journal Of Preventive Cardiology 2025, zwaf525. PMID: 40827363, DOI: 10.1093/eurjpc/zwaf525.Peer-Reviewed Original ResearchAnticoagulants for Atrial Fibrillation in Survivors of Intracranial Hemorrhage A Meta-Analysis of Randomized Trials
Chi K, Chang Y, Lee P, Rossi R, Lin Y, Akman Z, Varrias D, Damluji A, Nanna M. Anticoagulants for Atrial Fibrillation in Survivors of Intracranial Hemorrhage A Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2025, 86: 287-290. PMID: 40701674, DOI: 10.1016/j.jacc.2025.04.069.Peer-Reviewed Original ResearchSystematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis
Mari T, Moeed A, Siddiqui A, Abbasi A, Arif Z, Jannat A, Akman Z, Rossi R, Unnar H, Bhatti H, Batool R, Khan M, Ali M, Batool F, Minahil, Iqbal J, Mena‐Hurtado C, Nanna M. Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis. Catheterization And Cardiovascular Interventions 2025, 106: 1324-1334. PMID: 40518749, DOI: 10.1002/ccd.31684.Peer-Reviewed Original ResearchCarotid artery stentingCarotid artery stenosisSingle-layer stentsDual-layer stentsAll-Cause MortalityPost-procedural strokeArtery stenosisRandomized Controlled TrialsStent occlusionHigher risk of peri-procedural strokePostprocedural strokeMeta-analysisRisk of peri-procedural strokeRisk ratioHigh riskCarotid artery stenting proceduresStroke riskPeri-procedural strokeRandom-effects meta-analysisPredictors of strokeTreat carotid artery stenosisLipid-rich carotid plaquesTreatment optionsArtery stentingPrimary outcomeGLP-1 RA Use and Major Adverse Cardiovascular Events in Patients With Monoclonal Gammopathy of Undetermined Significance
Chi K, Song J, Desphande S, Lee P, Soni A, Gonzales-Uribe A, Lessa Y, Morgan A, Chang Y, Lin Y, Akman Z, Nouri A, Rossi R, Babapour G, Varrias D, Parker T, Baldassarre L, Jha A, Muchtar E, Hull S, Kwan J, Nanna M. GLP-1 RA Use and Major Adverse Cardiovascular Events in Patients With Monoclonal Gammopathy of Undetermined Significance. JAMA Network Open 2025, 8: e2517541. PMID: 40587132, PMCID: PMC12210086, DOI: 10.1001/jamanetworkopen.2025.17541.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1GLP-1 RAsNew-onset HFAcute kidney injuryEnd-stage kidney diseaseScore matching analysisPrimary preventionMonoclonal gammopathyTransient ischemic attackCohort studyDecompensated HFMGUS diagnosisRA usersKidney injuryHeart failureRA useKidney diseaseIschemic attackEffects of GLP-1 RAsMajor adverse cardiovascular eventsProspective randomized trialsSecondary end pointsRisk of cardiovascular diseaseRetrospective cohort studyAdverse cardiovascular eventsValidation of the Coping with Health Injuries and Problems questionnaire in a longitudinal cohort with recent-onset RA
Akman Z, Boire G, Carrier N, Roux S, Masetto A, de Brum-Fernandes A, Liang P, Allard-Chamard H. Validation of the Coping with Health Injuries and Problems questionnaire in a longitudinal cohort with recent-onset RA. Rheumatology Advances In Practice 2025, 9: rkaf057. PMID: 40686915, PMCID: PMC12274643, DOI: 10.1093/rap/rkaf057.Peer-Reviewed Original ResearchInternal consistencyTreatment adherenceBack pain patientsHealth injuriesYears of follow-upFollow-upCohort of early rheumatoid arthritisCronbach's alphaPain patientsDiagnosed RA patientsIndividual coping stylesRheumatoid arthritisFollow-up visitPsychometric propertiesCoping stylesLongitudinal cohortRecent-onset rheumatoid arthritisConfirmatory factor analysisProspective cohortInstrument itemsSubscalesProblems QuestionnaireRA patientsFactor structureEarly rheumatoid arthritisContemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation
Park D, McLean B, Akman Z, Li D, Babapour G, Nanna M. Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038589. PMID: 40401606, PMCID: PMC12229217, DOI: 10.1161/jaha.124.038589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAspirinAtrial FibrillationClinical RelevanceDrug Therapy, CombinationDual Anti-Platelet TherapyFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionST-segment elevation myocardial infarctionDouble therapyTriple therapyClinical adverse eventsIn-Hospital MortalityAtrial fibrillationPost-PCIMyocardial infarctionIntracranial hemorrhageAdverse eventsCourse of triple therapyCoronary interventionStent thrombosisInverse probability of treatment weightingProbability of treatment weightingHigh-risk subgroupsMultivariate logistic regressionAssociated with higher oddsRandomized trial evidenceNo significant differenceVizient clinical databaseClinical significancePrescribing patternsCompare outcomesTAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis
Krishna M, Joseph M, Ezenna C, Pereira V, Rossi R, Akman Z, Rubens M, Mahadevan V, Nanna M, Goldsweig A. TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis. Cardiovascular Revascularization Medicine 2025, 79: 78-89. PMID: 40425422, DOI: 10.1016/j.carrev.2025.05.021.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementPatient-prosthesis mismatchIntermediate surgical riskSevere patient-prosthesis mismatchAcute kidney injuryAortic valve replacementPermanent pacemaker implantationRandomized Controlled TrialsSurgical riskParavalvular leakFollow-upValve replacementPacemaker implantationAtrial fibrillationClinical outcomes of transcatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementRate of permanent pacemaker implantationSafety of transcatheter aortic valve replacementBenefits of transcatheter aortic valve replacementNew-onset atrial fibrillationRates of all-cause deathAortic valve reinterventionNew-onset AFSevere aortic stenosis
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