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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yuping Zhou's published research.
Publications Timeline
A big-picture view of Yuping Zhou's research output by year.
Hugh Taylor, MD
Graciela Krikun, PhD
Lingeng Lu, MD, PhD
Myles Alderman III, PhD
Ramanaiah Mamillapalli, PhD
14Publications
892Citations
Publications
2024
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test
2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2019
miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice
Li M, Zhou Y, Taylor HS. miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice. Reproductive Sciences 2019, 26: 1506-1511. PMID: 31354069, DOI: 10.1177/1933719119862050.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMiR-451a inhibitorReproductive-age womenTreatment of endometriosisPro-inflammatory diseasesSystemic treatmentEndometriosis lesionsIL-6Chronic diseasesPromising therapyCurrent treatmentMicroRNA-451aMurine modelSex steroidsEndometriosisLesion sizeVisible lesionsMiR-451aMicroRNAs treatmentsDiseaseAltered expressionΒ-cateninTreatmentLesionsInhibitorsMultiple pathwaysNFκB2 expression in endometriosis is regulated by miRNA Let-7b
Flores V, Chen P, Huttler J, Zhou Y, Dang T, Mamillapalli R, Taylor H. NFκB2 expression in endometriosis is regulated by miRNA Let-7b. Fertility And Sterility 2019, 112: e327-e328. DOI: 10.1016/j.fertnstert.2019.07.947.Peer-Reviewed Original ResearchCitations
2017
Cigarette Smoking Affects Uterine Receptivity Markers
Ersoy G, Zhou Y, Inan H, Taner CE, Cosar E, Taylor HS. Cigarette Smoking Affects Uterine Receptivity Markers. Reproductive Sciences 2017, 24: 989-995. PMID: 28285568, DOI: 10.1177/1933719117697129.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHuman endometrial stromal cell lineCigarette smoking extractReceptivity markersImmunohistochemical analysisEndometrial stromal cell linePrimary human endometrial stromal cellsHuman endometrial stromal cellsFGF2 protein expressionUterine receptivity markersFGF2 expressionCigarette smoke exposureImpact of smokingEffect of smokingImpaired endometrial receptivityReal-time reverse transcription-polymerase chain reactionEndometrial stromal cellsC motif chemokine ligand 12Human endometrial samplesExpression of cytokinesReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionChemokine ligand 12FGF2 mRNA expressionMouse uterine tissueEndometrial health
2016
Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis
Cho S, Mutlu L, Zhou Y, Taylor HS. Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis. Fertility And Sterility 2016, 106: 673-680. PMID: 27320036, PMCID: PMC5831184, DOI: 10.1016/j.fertnstert.2016.05.020.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman endometrial stromal cellsLet-7f mimicIshikawa cellsL treatment groupEndometrial cellsAromatase expressionTreatment groupsEndometrial stromal cellsAromatase inhibitor treatmentPathogenesis of endometriosisLet-7f expressionSignificant differencesDose-dependent mannerLetrozole treatmentModulation of microRNAsAromatase inhibitorsLaparoscopic surgeryMAIN OUTCOMEAI treatmentEndometriosisLetrozole concentrationsTherapeutic levelsInhibitor treatmentControl groupTherapeutic potential
2015
Frequent migration of ectopic endometrial cells to the brain in a murine model of endometriosis
Samani E, Li F, Krikun G, Ilagan Y, Mutlu L, Zhou Y, Naqvi H, Taylor H. Frequent migration of ectopic endometrial cells to the brain in a murine model of endometriosis. Fertility And Sterility 2015, 104: e69. DOI: 10.1016/j.fertnstert.2015.07.211.Peer-Reviewed Original ResearchCitations
2012
FKBP4 is regulated by HOXA10 during decidualization and in endometriosis
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction 2012, 143: 531-538. PMID: 22279148, DOI: 10.1530/rep-11-0438.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman endometrial stromal cellsFKBP4 expressionFKBP5 expressionTreatment of hESCCultured human endometrial stromal cellsIGFBP1 expressionEndometrium of womenProtein levelsEndometrial stromal cellsLate proliferative phaseHOXA10 knockdownHOXA10 regulationImpaired decidualizationFertile womenEutopic endometriumMenstrual cycleSecretory phaseEndometriosisDecidualizationHOXA10 expressionProliferative phaseStromal cellsMRNA expressionFKBP5FKBP4
2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometriumCigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1
Zhou Y, Jorgensen EM, Gan Y, Taylor HS. Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1. Biology Of Reproduction 2011, 84: 1242-1247. PMID: 21325691, PMCID: PMC3099588, DOI: 10.1095/biolreprod.110.087494.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProgesterone receptorCigarette smokeRate of endometriosisEffect of smokingCigarette smoke extractEndometrial stromal cellsExpression of HOXA10Poor health outcomesEndometrial cancerEndometrial pathologyEndometrial diseaseCigarette smokingDecreased incidenceOvarian alterationsDecreased prevalenceEndometrial tumorsEndometrial differentiationEndometrial cellsHuman endometriumSmoke extractProtective effectHomeobox A10Health outcomesHomeobox A10 expressionSmoking
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