Yuan Huang, PhD
Assistant Professor of Biostatistics (Biostatistics)Cards
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Assistant Professor of Biostatistics (Biostatistics)
Biography
Yuan Huang is an Assistant Professor in the Department of Biostatistics at Yale School of Public Health. Her methodological research is focused on statistical methods for high-dimensional data and has been motivated by challenges posted by analyzing cancer genomics, such as low reproducibly, nonlinearity, and heterogeneity. Applications from her work include biomarker identification, large-scale network structure estimation, GxE analysis, etc. She is particularly interested in integrative analysis that simultaneously analyzes multiple datasets to improve the discovery. Recently she collaborates extensively in neurodegenerative diseases and movement disorders, such as Alzheimer's disease, Huntington’s disease, and Parkinson's disease . She is also actively involved in collaborative research on clinical trials, genetics, epidemiology, and other biomedical fields.
Appointments
Biostatistics
Assistant ProfessorPrimary
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Education & Training
- PhD
- The Pennsylvania State University, Statistics
Research
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Public Health Interests
ORCID
0000-0002-8011-3034
Publications
2026
Unobserved heterogeneity in threshold regression based on the hitting times of a reflected Brownian motion for recurrent hypoglycemia
Xie Y, Fu H, Huang Y, Yan J. Unobserved heterogeneity in threshold regression based on the hitting times of a reflected Brownian motion for recurrent hypoglycemia. Lifetime Data Analysis 2026, 32: 36. PMID: 42228213, DOI: 10.1007/s10985-026-09717-x.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBrownian motionBayesian model comparison criteriaPseudo-marginal likelihoodModel comparison criteriaMarkov chain Monte CarloWithin-subject dependenceDeviance information criterionFinite mixture modelHitting timeRegression coefficientsPseudo-marginalFrailty parametersSimulation studyModel selectionInformation criterionBayesian frameworkMonte CarloThreshold regressionUnobserved heterogeneityMixture modelComparison criteriaVolatilityMarkovLogarithmInferenceEmpowering classification for multivariate functional data with simultaneous feature selection.
Wang S, Cao G, Huang Y. Empowering classification for multivariate functional data with simultaneous feature selection. Statistical Methods In Medical Research 2026, 9622802261449366. PMID: 42138358, DOI: 10.1177/09622802261449366.Peer-Reviewed Original ResearchConceptsMultivariate functional dataInfinite-dimensional function spaceDeep neural networksSimultaneous feature selectionFunction spacesRandom elementsFunctional predictorsClassification taskData classifierFunctional dataNetwork architectureDistributional assumptionsFeature selectionNeural networkAvailability of imaging dataSimulation studyData applicationsData typesFavorable performanceImage dataClassifierClassificationAlzheimer's Disease Neuroimaging InitiativeSample sizeLassoNetSubgroup Identification by Supervised Clustering Analysis of Disease Outcomes and Biomarkers with Repeated Measurements
Mao Y, Mou Y, Zhan X, Huang Y. Subgroup Identification by Supervised Clustering Analysis of Disease Outcomes and Biomarkers with Repeated Measurements. Journal Of Systems Science And Complexity 2026, 39: 1269-1284. DOI: 10.1007/s11424-026-5169-9.Peer-Reviewed Original ResearchGeneralizing the Finkelstein–Schoenfeld Test to Incorporate Multiple Alternating Thresholds
Mou Y, Kyriakides T, Hummel S, Li F, Huang Y. Generalizing the Finkelstein–Schoenfeld Test to Incorporate Multiple Alternating Thresholds. Biometrical Journal 2026, 68: e70117-e70117. PMID: 41761447, PMCID: PMC13052009, DOI: 10.1002/bimj.70117.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsAdaptive Incorporation of External Summary Information in the Cox Regression Under Population Heterogeneity
Li Y, Huang Y, Sheng Y, Zhang Q. Adaptive Incorporation of External Summary Information in the Cox Regression Under Population Heterogeneity. Statistics In Medicine 2026, 45: e70371. PMID: 41572651, DOI: 10.1002/sim.70371.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCovariate effectsMaximum partial likelihood estimatorRight-censored survival dataEstimation of covariate effectsPartial likelihood estimatorFinite-sample performancePartial likelihood functionParameter estimation efficiencyAsymptotic normalityRegression parametersLikelihood estimationEstimation consistencyLikelihood functionSimulation studyEstimation efficiencyFusion penaltySurvival dataEstimationMild conditionsParameter heterogeneityCluster structurePopulation heterogeneityCovariatesIndividual-level dataConsistencyBHMnet: Bayesian high-dimensional mediation analysis with network information integration for correlated mediators
Im Y, Huang Y. BHMnet: Bayesian high-dimensional mediation analysis with network information integration for correlated mediators. Briefings In Bioinformatics 2026, 27: bbaf734. PMID: 41554050, PMCID: PMC12814977, DOI: 10.1093/bib/bbaf734.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsDurability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Sriskantharajah V, Hynes D, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans. JAMA Internal Medicine 2026, 186: 78-88. PMID: 41284307, PMCID: PMC12645397, DOI: 10.1001/jamainternmed.2025.6355.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRespiratory syncytial virus vaccineRespiratory syncytial virusIntensive care unit admissionRSV vaccineVaccine effectivenessUnit admissionRespiratory syncytial virus illnessSevere respiratory syncytial virusVaccine doseRespiratory syncytial virus infectionMonths of follow-upLong-term effectsHealth care useRespiratory illness seasonVeterans Health AdministrationMatched index dateUrgent care visitsTarget trial emulationMedian ageCare useCare visitsSingle doseSyncytial virusIndex dateVaccine recipients
2025
Effectiveness of the 2024–2025 KP.2 COVID-19 vaccines in the United States during long-term follow-up
Ioannou G, Berry K, Yan L, Huang Y, Lin H, Bui D, Hynes D, Boyko E, Ferguson J, Aslan M, Bajema K. Effectiveness of the 2024–2025 KP.2 COVID-19 vaccines in the United States during long-term follow-up. Nature Communications 2025, 17: 1043. PMID: 41444246, PMCID: PMC12847879, DOI: 10.1038/s41467-025-67796-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVaccine effectivenessED/UC visitsUp-to-date estimatesFollow-upCOVID-19 vaccineLong-term follow-upLong-term vaccine effectivenessSARS-CoV-2 infectionVeterans Health AdministrationEmergency department/urgent careSARS-CoV-2-associated deathsVaccination strategiesStudy populationCOVID-19 vaccine effectivenessHealth AdministrationInfectionOmicron variantCOVID-19 vaccination strategiesHospitalVaccineCOVID-19DeathEstimates of COVID-19 vaccine effectivenessVisitsImpact of time zero designation on estimated COVID-19 antiviral effectiveness in observational studies
Bajema K, Yan L, Berry K, Bui D, Lin H, Huang Y, Li Y, Rajeevan N, Maciejewski M, Smith V, Bohnert A, Hynes D, Aslan M, Ioannou G. Impact of time zero designation on estimated COVID-19 antiviral effectiveness in observational studies. American Journal Of Epidemiology 2025, 195: 562-568. PMID: 41078178, DOI: 10.1093/aje/kwaf221.Peer-Reviewed Original ResearchCitationsAltmetricMetabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study
Zhang L, Yeung C, Lee K, Shadyab A, LaCroix A, Stone K, Yaffe K, Hayden K, Casanova R, Rapp S, Chen J, Baker L, Manson J, Huang Y, Xiao Q. Metabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study. Sleep 2025, 49: zsaf320. PMID: 41071097, PMCID: PMC12795739, DOI: 10.1093/sleep/zsaf320.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIngenuity Pathway AnalysisMetabolomic biomarkersMass spectrometryRest-activity rhythmOlder womenRest-activity rhythm characteristicsLiquid-phase chromatographyTandem mass spectrometryWomen's Health Initiative studyGas chromatography coupled with mass spectrometryWomen's Health InitiativeAssociated with riskUntargeted approachMetabolomics dataAccelerometry dataCardiometabolic diseasesHealth initiativesRest-activity rhythm variablesLinear regression modelsMultiple linear regression modelSerum samplesSpectrometryRhythm variabilityMetabolomicsWomen
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300 George Street
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Fl 5th , Ste Ste 511
New Haven, CT 06511