About
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Research Associate Internal Medicine Cardiology
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xiaohong Wu's published research.
Fadi Gabriel Akar, PhD
Lawrence Young, MD
Dongyan Zhang
Gary Cline, PhD
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
Jiasheng Zhang, MD
Publications
2024
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Goedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, Galsgaard K, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard B, Haedersdal S, Wu X, Stack J, Dufour S, Butrico G, Kahn M, Perry R, Cline G, Young L, Shulman G. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. Journal Of Clinical Investigation 2024, 134: e176708. PMID: 39680452, PMCID: PMC11645152, DOI: 10.1172/jci176708.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSodium-glucose cotransporter type 2Heart failureKetone oxidationGas chromatography-mass spectrometryFatty acid oxidationLeft ventricular ejection fractionReduced myocardial oxidative stressVentricular ejection fractionKetone supplementationWeeks of treatmentMyocardial oxidative stressDecreased pyruvate oxidationInduce heart failurePlasma glucose levelsIn vivo effectsSGLT2i treatmentEjection fractionAssociated with improvementsAwake ratsSGLT2 inhibitionCardioprotective benefitsLiquid chromatography-tandem mass spectrometryPlasma ketonesRates of ketonizationChromatography-tandem mass spectrometryMP-470551-008 ATRIAL FIBRILLATION IN MICE WITH AMPK DELETION IS MEDIATED BY TRIGGERED ACTIVITY FROM THE PULMONARY VEIN JUNCTION
Cacheux M, Velasco J, Wu X, Akar J, Young L, Akar F. MP-470551-008 ATRIAL FIBRILLATION IN MICE WITH AMPK DELETION IS MEDIATED BY TRIGGERED ACTIVITY FROM THE PULMONARY VEIN JUNCTION. Heart Rhythm 2024, 21: s107. DOI: 10.1016/j.hrthm.2024.03.1772.Peer-Reviewed Original ResearchConceptsPO-05-168 CARDIOMYOCYTE STIM1 EXPRESSION REGULATES POST-ISCHEMIC CARDIAC FUNCTION BY CONTROLLING METABOLIC PROCESSES AND MITOCHONDRIAL ULTRASTRUCTURE
Cacheux M, Wu X, Akar F. PO-05-168 CARDIOMYOCYTE STIM1 EXPRESSION REGULATES POST-ISCHEMIC CARDIAC FUNCTION BY CONTROLLING METABOLIC PROCESSES AND MITOCHONDRIAL ULTRASTRUCTURE. Heart Rhythm 2024, 21: s570-s571. DOI: 10.1016/j.hrthm.2024.03.1439.Peer-Reviewed Original Research
2023
Role of AMPK pathway inactivation in high fat diet related cardiac electrophysiological remodeling
Rudokas M, Cacheux M, Wu X, Hummel M, Young L, Akar F. Role of AMPK pathway inactivation in high fat diet related cardiac electrophysiological remodeling. Biophysical Journal 2023, 122: 380a-381a. DOI: 10.1016/j.bpj.2022.11.2089.Peer-Reviewed Original Research
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