Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores
Cadenhead K, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores. Schizophrenia Bulletin 2024, sbae182. PMID: 39488001, DOI: 10.1093/schbul/sbae182.Peer-Reviewed Original ResearchClinical high riskClinical high-risk participantsClinical high-risk researchPremorbid functioningResilient outcomesProtective factorsClinical high-risk youthClinical high-risk populationsReduced startle reactivityPrediction of psychosisAssociated with greater resilienceHigh-risk youthStudy of protective factorsStartle reactivityPsychotic conversionBrain areasPsychosisChildhood environmentBrain developmentGreater resilienceExploratory analysisLife experiencesPreventive interventionsSocial engagementHispanic heritageImpact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis
Giampetruzzi E, Walker E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, LoPilato A. Impact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis. Psychiatry Research 2024, 342: 116214. PMID: 39368239, DOI: 10.1016/j.psychres.2024.116214.Peer-Reviewed Original ResearchAdverse childhood experiencesClinical high riskEffects of protective factorsInternalizing disordersDepressive disorderCHR-PEmotional neglectSelf-harm/suicideProtective factorsChildhood experiencesHigher levels of adverse childhood experiencesHistory of depressive disorderSexual abuseLevels of adverse childhood experiencesInternalizing psychiatric disordersChildhood sexual abusePresence of protective factorsImpact of adverse childhood experiencesAnxiety disordersAdministered measuresPsychiatric diagnosisPsychiatric disordersPsychiatric outcomesChild adversitySubstance use