Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Woods S, Walker E, Miller B. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Research 2024, 341: 116147. PMID: 39197223, DOI: 10.1016/j.psychres.2024.116147.Peer-Reviewed Original ResearchPsychosis-risk symptomsClinical high riskSuicidal ideationCHR-P individualsCHR-PSleep disturbanceTerminal insomniaNorth American Prodrome Longitudinal StudyAssociated with conversion to psychosisSleep problemsConversion to psychosisTreatment of sleep disturbancesAssociated with SIIndices of sleep disturbanceMultiple indicesPsychosisIdeationLongitudinal intervention studyInsomniaLongitudinal studySchizophreniaSymptomsSleepSymptom scoresInvestigate relationshipsNeurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning
Carrión R, Ku B, Dorvil S, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cornblatt B. Neurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning. Schizophrenia Research 2024, 271: 129-137. PMID: 39024961, DOI: 10.1016/j.schres.2024.06.054.Peer-Reviewed Original ResearchClinical high riskCHR-PNeurocognitive deficitsImpact of processing speedProcessing speedNorth American Prodrome Longitudinal StudyBaseline processing speedCHR-P participantsPoor social functioningCHR-P individualsYoung adultsDisorganized symptomsBaseline neurocognitionAttentional impairmentAttention deficitDevelopmental trajectoriesNeurocognitionPsychosisImpact of symptomsProdromal phaseSocial functioningIntervention issuesTreatment targetLongitudinal studyDeficitsThe Hierarchical Taxonomy of Psychopathology in Clinical High Risk for Psychosis: Validation and Extension
Williams T, Williams A, Cowan H, Walker E, Cannon T, Bearden C, Keshavan M, Cornblatt B, Addington J, Woods S, Perkins D, Mathalon D, Cadenhead K, Stone W, Mittal V. The Hierarchical Taxonomy of Psychopathology in Clinical High Risk for Psychosis: Validation and Extension. Journal Of Psychopathology And Clinical Science 2024, 133: 235-244. PMID: 38546628, PMCID: PMC11273326, DOI: 10.1037/abn0000893.Peer-Reviewed Original ResearchConceptsHierarchical Taxonomy of PsychopathologyTaxonomy of PsychopathologyClinical high riskHiTOP modelCHR-PChildhood traumaDimensional models of psychopathologyHierarchical taxonomyModels of psychopathologyAttenuated psychotic symptomsBipolar spectrum disordersObsessive-compulsive disorderCHR-P individualsConfirmatory factor analysisPsychotic symptomsPsychotic disordersComorbid diagnosesHiTOPSpectrum disorderPsychosisPsychopathologySocial functioningSelf-reportSpecific hypothesesTest specific hypotheses