Tommaso Volpi
Postdoctoral AssociateDownloadHi-Res Photo
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Postdoctoral Associate
Biography
During his PhD, Tommaso has worked on kinetic modelling of multiple PET tracers ([18F]FDG, [15O]H2O, [15O]O2) and integration with resting-state fMRI using multivariate analysis, with additional focus on image-derived input function and PET connectivity methods. Current projects involve mathematical modelling of PET data to obtain information on brain physiology (metabolism, receptor and synaptic density), and applications to brain disorders, including schizophrenia and Parkinson's disease.
Last Updated on September 07, 2025.
Appointments
Radiology & Biomedical Imaging
Postdoctoral AssociatePrimary
Other Departments & Organizations
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- Radiology & Biomedical Imaging
Education & Training
- PhD
- University of Padova, Padova Neuroscience Center (2022)
- MD
- University of Padova (2017)
Research
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Overview
Medical Research Interests
Brain; Neurodegenerative Diseases; Positron-Emission Tomography; Schizophrenia Spectrum and Other Psychotic Disorders
Public Health Interests
Biomarkers; Modeling
ORCID
0000-0002-5451-6710
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tommaso Volpi's published research.
Publications Timeline
A big-picture view of Tommaso Volpi's research output by year.
Research Interests
Research topics Tommaso Volpi is interested in exploring.
Richard Carson, PhD
David Matuskey, MD
Jean-Dominique Gallezot, PhD
Ansel Hillmer, PhD
Shannan Henry
Takuya Toyonaga, MD, PhD
26Publications
203Citations
Positron-Emission Tomography
Publications
2026
Molecular connectivity studies of cerebral glucose metabolism and blood flow: A scoping review
Cavaliere C, Galli A, Meneghini C, Severino M, Peretti D, Nørgaard M, Tang C, Martini A, Bardiau M, Doyen M, Gonzalez-Escamilla G, Horwitz T, Perovnik M, Rullmann M, Talmasov D, Volpi T, Xu Z, Calhoun V, Di X, Eickhoff S, Habeck C, Jamadar S, Perani D, Sossi V, Yakushev I, Sala A, Pereira J, Veronese M, Caminiti S. Molecular connectivity studies of cerebral glucose metabolism and blood flow: A scoping review. Neuroscience & Biobehavioral Reviews 2026, 185: 106623. PMID: 41794200, DOI: 10.1016/j.neubiorev.2026.106623.Peer-Reviewed Original ResearchAltmetricConceptsGlucose metabolismBlood flowStudies of cerebral glucose metabolismMacroscale brain connectivityBrain connectivityCerebral blood flowStudies of cerebral blood flowMetabolic connectivityCerebral glucose metabolismDefault mode networkDisease progressionF]FDG-PETPET/MRI studiesBrain-body interactionsDisorders of consciousnessBrain functional organizationPET/MRI dataClinical relevancePerfusion studiesBrain perfusionRegional perfusionHemodynamic connectivity"Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.
Volpi T, Naganawa M, Carson R, Hillmer A. "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 271678x251411712. PMID: 41543053, PMCID: PMC12811094, DOI: 10.1177/0271678x251411712.Peer-Reviewed Original ResearchAltmetric
2025
Predicting visual object memory through natural eye movement topography.
Celli M, Cona G, Volpi T, Tronelli V, Zangrossi A, Corbetta M. Predicting visual object memory through natural eye movement topography. Sci Rep 2025, 15: 43606. PMID: 41381646, DOI: 10.1038/s41598-025-27312-2.Peer-Reviewed Original ResearchBrain metabolic-functional (de)coupling from health to glioma dysfunction.
Vallini G, Baron G, Silvestri E, Volpi T, Vlassenko AG, Goyal MS, Chiuso A, Cecchin D, Corbetta M, Bertoldo A. Brain metabolic-functional (de)coupling from health to glioma dysfunction. Commun Biol 2025, 9: 5. PMID: 41345236, DOI: 10.1038/s42003-025-09181-7.Peer-Reviewed Original ResearchExceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT
Volpi T, Toyonaga T, Khattar N, Gallezot J, Naganawa M, Vanderlinden G, Honhar P, Zeng T, Fontaine K, Mulnix T, Hu L, Sun X, Henry S, Matuskey D, Radhakrishnan R, Guo L, Hu Y, Zhang J, Zheng X, Nabulsi N, Huang Y, Badawi R, Cherry S, Hillmer A, Jones T, Liu C, Morris E, Qi J, Li H, Carson R. Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 53: 2110-2121. PMID: 41177836, PMCID: PMC12860869, DOI: 10.1007/s00259-025-07605-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStandardized uptake valueTargeted radiopharmaceuticalsDopamine systemMultiple cortical areasSerotonin transporterRaphe nucleusMeasurement of tracer uptakeBrain regionsBrain structuresSubcortical nucleiPositron emission tomographyCortical areasSynaptic densityPET researchFocal uptakePaired scansUptake valueTracer uptakePET systemGray matterEarly imagesEmission tomographyHealthy individualsTracer deliveryNeuroExplorerMeasuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study
Sadabad F, Volpi T, Honhar P, Tinaz S, Dias M, Toyonaga T, Naganawa M, Gallezot J, Yang Y, Ibrahim W, Pittman B, Cayir S, Radhakrishnan R, Angarita G, Holmes S, Comley R, Carson R, Finnema S, Matuskey D. Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study. Movement Disorders 2025, 40: 2678-2687. PMID: 41040062, DOI: 10.1002/mds.70041.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsC-UCB-JDopamine transporterHealthy controlsVentral striatumDisease stageSubstantia nigraSynaptic densityParkinson's diseaseDopamine transporter availabilityPositron emission tomography imaging studiesSynaptic vesicle glycoprotein 2AAssessment of synaptic densityDopaminergic denervationBetween-group differencesTransporter availabilityBinding potentialNigrostriatal regionDisease durationDual-tracerImaging studiesPatientsPET imagingPresynaptic degenerationPD patientsDopamineCarotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.
Volpi T, Gallezot J, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer A, Matuskey D, Carson R. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. Journal Of Nuclear Medicine 2025, 66: 1993-2001. PMID: 41043999, PMCID: PMC12676648, DOI: 10.2967/jnumed.125.270414.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsArea under the curveCommon carotidTime-activity curvesLate area under the curveMethods:Carotid arteryRegions-of-interestResults:Blood samplesPartial volume effectsImage-derived input functionArterial blood samplesArterial input functionAlternative to arterial blood samplingBlood time-activity curvesPET kinetic modelingGold standardInput functionBackground activityArterial samplesCarotidBrain-dedicated PET scannersBrain PETToward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates
Gravel P, Gu J, Wang C, Volpi T, Gallezot J, Holden D, Fowles K, Zheng M, Zhang L, Borroni E, Honer M, Gobbi L, Tamagnan G, Huang Y, Carson R. Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates. Journal Of Nuclear Medicine 2025, 66: 1652-1658. PMID: 40908122, PMCID: PMC12487869, DOI: 10.2967/jnumed.125.270332.Peer-Reviewed Original ResearchCitationsAltmetricConceptsGABA transporter type 1Nonhuman primatesGAT-1Brain uptakeNondisplaceable binding potentialSubcortical gray matter regionsHuman studiesG-aminobutyric acidLow brain uptakeGray matter structuresLow specific bindingConclusion:Methods:Gray matter regionsType 1Results:Neuropsychiatric disordersPET radiotracersBinding potentialGABA signalingVolume of distributionMatter structuresRhesus monkeysBlock scanningGABA receptorsCondensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization.
Chhabra A, Hoffmann C, Aguilar Pérez G, Korobeinikov AA, Rentsch J, Hümpfer N, Kokwaro L, Gnidovec L, Petrović A, Wallace JN, Tromm JV, Román-Vendrell C, Johnson EC, Ranković B, Perego E, Volpi T, Fernández-Busnadiego R, Köster S, Rizzoli SO, Ewers H, Morgan JR, Milovanović D. Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization. EMBO J 2025 PMID: 40813925, DOI: 10.1038/s44318-025-00516-y.Peer-Reviewed Original ResearchConnecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography
Reed M, Cocchi L, Sander C, Chen J, Matheson G, Fisher P, Volpi T, Khattar N, DeLorenzo C, Gryglewski G, Silberbauer L, Murgaš M, Godbersen G, Nics L, Walter M, Hacker M, Bertoldo A, Lubberink M, Silfstein M, Ogden R, Mann J, Suhara T, Varrone A, Boellaard R, Gunn R, Hammers A, Biswal B, Rosen B, Knudsen G, Carson R, Price J, Lanzenberger R, Hahn A. Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 53: 48-58. PMID: 40455254, PMCID: PMC12660352, DOI: 10.1007/s00259-025-07357-1.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFunctional connectivityFMRI resting-state functional connectivityResting-state functional connectivityNeurobiological underpinningsMeasured PET signalBrain regionsConnectivity analysisPositron emission tomographyConnectivity metricsConnectivity studiesBetween-subjectsPET signalEmission tomographyBrainImaging modalitiesDiverse methodologiesMolecular connectivityMolecular covariatesFMRIPositron
Academic Achievements & Community Involvement
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Activities
activity Image-Derived Input Functions on an Ultra-High Performance Brain PET Scanner: Minimizing the Carotid Partial Volume Effect
10/26/2024 - 11/02/2024Poster PresentationIEEE NSS MIC RTSD 2024DetailsTampa; FL, USACollaboratorsactivity PET Kinetic Modeling on Ultra-High Performance Scanners: can we finally trust the Microparameters?
06/08/2024 - 06/11/2024Poster PresentationSNMMI Annual Meeting 2024DetailsToronto, ON, CanadaCollaboratorsactivity Image-Derived Input Functions and Ultra-High Performance Brain PET scanners: have we finally made it?
06/08/2024 - 06/11/2024Oral PresentationSNMMI Annual Meeting 2024DetailsToronto, ON, CanadaCollaboratorsactivity Fick’s Principle is back: can we get a Whole-Brain Blood Flow estimate from (almost) any PET tracer?
06/08/2024 - 06/11/2024Oral PresentationSNMMI Annual Meeting 2024DetailsToronto, ON, CanadaCollaboratorsactivity A Novel Approach to Modeling Enzyme Turnover Rates after Irreversible Inhibition: a Proof-Of-Concept Brain PET Study in Non-Human Primates
05/18/2024 - 05/21/2024Poster PresentationNeuroReceptor Mapping 2024DetailsMontreal, QC, CanadaCollaborators
Honors
honor JNM Editors’ Choice Awards for 2024
06/21/2025International AwardJournal of Nuclear MedicineDetailsUnited Stateshonor Brain & Brain PET 2025 Travel Award
06/04/2025International AwardBrain & Brain PET 2025honor PIDSC Young Investigator Award - Honorable Mention
06/09/2024International AwardSNMMI Annual Meeting 2024DetailsCanadahonor NIH Travel Award 2023
09/09/2023International AwardWMIC 2023DetailsCzech Republichonor Brain Imaging Council Travel Award
06/27/2023International AwardSNMMI Annual Meeting 2023
News
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News
- December 08, 2025
Powerful New Brain PET Scanner Is Opening New Research Pathways
- November 24, 2025
Brain Markers Could Yield Early Clues into Parkinson’s Disease
- June 13, 2025
NeuroEXPLORER Paper wins Journal of Nuclear Medicine's Editors' Choice Award as the best clinical article
- June 02, 2025
Zeng receives travel award for SNMMI
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