Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4
Liddiard K, Ruis B, Takasugi T, Harvey A, Ashelford K, Hendrickson E, Baird D. Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4. Genome Research 2016, 26: 588-600. PMID: 26941250, PMCID: PMC4864465, DOI: 10.1101/gr.200840.115.Peer-Reviewed Original ResearchConceptsFusion eventsLarge-scale genomic rearrangementsCancer genome evolutionDNA ligase 3Nonhomologous end-joining repairTelomere fusion eventsDNA ligase 1DNA ligase 4High-throughput sequence analysisEnd-joining repairGenome evolutionDistinct mutational signaturesGenomic lociTelomere fusionCheckpoint controlSister chromatidsStable genomeCell divisionLigase 1Ligase 3Alternative NHEJNonhomologous endSingle-molecule levelClassical NHEJGenomic rearrangements