Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination
Ruis B, Molan A, Takasugi T, Hendrickson E. Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination. DNA Repair 2019, 85: 102738. PMID: 31731258, PMCID: PMC6952554, DOI: 10.1016/j.dnarep.2019.102738.Peer-Reviewed Original ResearchConceptsXRCC4-like factorDNA repairC-NHEJDSB repairHuman cellsNon-Homologous End Joining (NHEJ) pathwayDNA DSB repairHuman somatic cellsDNA damaging agentsInfluences DNA repairRepair of DNASpecies-specific differencesCell linesDsb proteinsHigher eukaryotesAccessory factorsParalogsSomatic cellsGenomic instabilityXRCC4 geneDamaging agentsEssential functionsSame cell linePAXXHCT116 cells