Sujin Kim
Associate Research ScientistCards
About
Research
Publications
2025
NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease.
Lee J, Sim S, Jin Y, Park H, Byeon EY, Kim SJ, Yun S, Lee HE, Jeong DU, Suh JM, Lee IH, Lee HY, Choi Y, Bae YS. NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease. Adv Sci (Weinh) 2025, e05495. PMID: 40823879, DOI: 10.1002/advs.202505495.Peer-Reviewed Original ResearchEC50 images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies.
Ibrahimy A, Kim S, Schmidt M, Slifstein M, Mannaert E, Andrews R, Matthews D, Constantinescu C, Searle G, Gunn R, Rabiner E, Morris E. EC50 images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies. Cerebrovascular And Brain Metabolism Reviews 2025, 271678x251353140. PMID: 40562708, PMCID: PMC12202393, DOI: 10.1177/0271678x251353140.Peer-Reviewed Original ResearchBinding potential mapsRepeat-doseSingle-doseDrug affinityJNJ-37822681Striatal subregionsVentral striatumDopamine receptorsChronic dosing studiesOccupational studiesHealthy male volunteersReceptor upregulationApparent affinityStriatumDrug trialsAntagonist drugsDose optimizationDose studyMale volunteersAnalysis of SDSpatial variationDrugDopamineCaudateOccupational image
2024
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease.
Park S, Park CW, Eom JH, Jo MY, Hur HJ, Choi SK, Lee JS, Nam ST, Jo KS, Oh YW, Lee J, Kim S, Kim DH, Park CY, Kim SJ, Lee HY, Cho MS, Kim DS, Kim DW. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease. Cell Stem Cell 2024, 31: 278-279. PMID: 38306996, DOI: 10.1016/j.stem.2024.01.006.Peer-Reviewed Original Research
2023
SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images
Ibrahimy A, Hoye J, Wu H, de Laat B, Kim S, Wilson D, Morris E. SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images. EJNMMI Physics 2023, 10: 80. PMID: 38079001, PMCID: PMC10713928, DOI: 10.1186/s40658-023-00600-4.Peer-Reviewed Original Research
2022
In vivo molecular imaging in preclinical research.
Kim SJ, Lee HY. In vivo molecular imaging in preclinical research. Lab Anim Res 2022, 38: 31. PMID: 36266669, DOI: 10.1186/s42826-022-00142-3.Peer-Reviewed Original ResearchPharmacokinetic evaluation of radiolabeled intraocular anti‐CLEC14a antibody in preclinical animal species and application in humans
Park S, Lee Y, Oh J, Kim S, Lee S, Lee H. Pharmacokinetic evaluation of radiolabeled intraocular anti‐CLEC14a antibody in preclinical animal species and application in humans. Clinical And Translational Science 2022, 15: 2938-2946. PMID: 36129122, PMCID: PMC9747121, DOI: 10.1111/cts.13412.Peer-Reviewed Original ResearchConceptsOne-compartment modelPK parametersHuman half-lifeVitreal volumeMacular degenerationTreatment of neovascular macular degenerationI-125PK characteristicsPharmacokinetic evaluationNeovascular macular degenerationAnti-angiogenic antibodyAntiangiogenic antibodiesIntraocular pharmacokineticsPreclinical animal speciesI-125-labeledHalf-life valuesAfliberceptAntiangiogenic activityHuman antibodiesTomography imagesTherapeutic agentsAnimal dataRatsAntibodiesMiceOne-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging.
Lee J, Kim J, Heo I, Kim SJ, Jang S, Lee HY, Jang KS, Yang CS, Lee Y, Yoo WC, Min SJ. One-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging. Biomater Sci 2022, 10: 3540-3546. PMID: 35611753, DOI: 10.1039/d2bm00258b.Peer-Reviewed Original Research
2021
Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice
Rahman F, Kim Y, Kim E, Kim H, Cho S, Lee C, Kim S, Araki K, Yamamura K, Lee M, Park S, Yoon W, Lee K, Won Y, Kim H, Lee Y, Lee H, Nam K. Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice. International Journal Of Molecular Sciences 2021, 22: 12806. PMID: 34884616, PMCID: PMC8657541, DOI: 10.3390/ijms222312806.Peer-Reviewed Original ResearchConceptsConnectivity alterationsBrain regionsOlfactory bulbDepression-like behaviorNeuro-behavioral changesBrain connectivity alterationsNeuropsychiatric disordersCentral nervous systemBehavioral disordersNeuropsychiatric phenotypesMental dysfunctionBrain functionGlobus pallidusPositron Emission Tomography/Computed TomographyAssociated with changesEmission Tomography/Computed TomographyCentral nervous system of miceNervous system of miceBrainDisordersTomography/Computed TomographyOptic nerveCircadian rhythmAmygdalaBulb
2020
Robust nonlinear parameter estimation in tracer kinetic analysis using infinity norm regularization and particle swarm optimization
Kang S, Seo S, Lee C, Kim M, Kim S, Lee J. Robust nonlinear parameter estimation in tracer kinetic analysis using infinity norm regularization and particle swarm optimization. Physica Medica 2020, 72: 60-72. PMID: 32200299, DOI: 10.1016/j.ejmp.2020.03.013.Peer-Reviewed Original ResearchConceptsParticle swarm optimizationProximal gradient algorithmSwarm optimizationImplementation of particle swarm optimizationGradient algorithmParticle swarm optimization methodNorm regularizationNon smooth cost functionLevenberg-Marquardt algorithmVoxel dataAlgorithmConvergence rateRegularization schemeCost functionInitial valuesOptimization methodRandom movementNonlinear parameter estimationPreliminary simulationsRegularizationStatistical propertiesNoise levelOptimizationConvergenceParameter estimation
2019
Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics
Li S, Zheng MQ, Naganawa M, Kim S, Gao H, Kapinos M, Labaree D, Huang Y. Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics. Journal Of Nuclear Medicine 2019, 60: 1023-1030. PMID: 30630942, PMCID: PMC6604690, DOI: 10.2967/jnumed.118.220517.Peer-Reviewed Original ResearchConceptsMultilinear analysis 1Κ-opioid receptor agonistCentral nervous system diseaseNervous system diseasesHigh specific bindingAgonist tracersGlobus pallidusReceptor abnormalitiesReceptor agonistFrontal cortexSystem diseasesPrimate brainReceptor occupancySuperior imaging characteristicsCingulate cortexAlzheimer's diseasePeak uptakeImaging characteristicsRhesus monkeysOptimal radiotracerPET studiesArterial input functionBlocking studiesPET radiotracersAnalysis 1
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- October 29, 2025
The NLPPPC workshop
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