Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsSinan Guloksuz, MD, PhD
Associate Professor Adjunct in PsychiatryAbout
Research
Publications
2025
Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study.
Pries L, Prachason T, Arias-Magnasco A, Lin B, Rutten B, Guloksuz S. Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study. The British Journal Of Psychiatry 2025, 1-8. PMID: 40899184, DOI: 10.1192/bjp.2025.36.Peer-Reviewed Original ResearchPsychotic experiencesPRS-SCZES-SCZAssociated with greater likelihoodAdolescent Brain Cognitive Development StudyAssociation of psychotic experiencesDevelopment of psychosisCognitive Development StudyFemale adolescentsPuberty statusNo significant interactionGreater likelihoodPubertal Development ScaleMental health outcomesAnnual follow-up assessmentsFollow-up assessmentAbsence of interactive effectsPsychosis scalesPolygenic risk scoresABCD studySchizophreniaOestradiol concentrationsFemale participantsDevelopment ScalePsychosisMental healthcare expenditure among adults by type of mental healthcare and its association with age and sex in the Netherlands between 2015 and 2020
Dijkstra L, Gülöksüz S, Batalla A, van Os J. Mental healthcare expenditure among adults by type of mental healthcare and its association with age and sex in the Netherlands between 2015 and 2020. PLOS ONE 2025, 20: e0330365. PMID: 40853948, PMCID: PMC12377576, DOI: 10.1371/journal.pone.0330365.Peer-Reviewed Original ResearchConceptsSpecialized mental healthcareMental healthcare expenditureMental healthcare costsMental healthcareHealthcare expendituresHealthcare costsMental health careType of careAge groupsYounger age groupsHealth careAssociated with ageOlder adultsYoung menHealth insuranceCohort studyHealthcareInteraction of ageCareYoung womenWomenLinear regressionSexAgeMenExamining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample
Karaçam Doğan M, Fusar-Poli L, Arias-Magnasco A, Pries L, Lin B, Klingenberg B, Bortoletto R, Colizzi M, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Luykx J, Prachason T, Guloksuz S. Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample. Schizophrenia Research 2025, 284: 133-140. PMID: 40774025, DOI: 10.1016/j.schres.2025.08.003.Peer-Reviewed Original ResearchCommunity Assessment of Psychic ExperiencesPsychosis expressionAutistic traitsOptimal parentingCommunity assessmentCoping stylesMultilevel linear regression modelsPsychosis vulnerabilityRisk factorsGeneral population twin samplePsychological protective factorsRisk of psychosisAutism Spectrum QuotientTotal frequency scoreReassuring thoughtsPsychological protective mechanismsSocial supportLinear regression modelsPrevention strategiesEngagement copingTwin samplePsychic ExperiencesCopingFrequency scoreExtraversionEvaluation of potential biomarker miRNAs and the levels of serotonin and dopamine in female patients with obsessive–compulsive disorder
Korkmaz N, Elibol B, Durmus Z, Ozdemir A, Akbas F, Guloksuz S, Sahbaz C. Evaluation of potential biomarker miRNAs and the levels of serotonin and dopamine in female patients with obsessive–compulsive disorder. Neuroscience 2025, 581: 50-57. PMID: 40614924, DOI: 10.1016/j.neuroscience.2025.07.001.Peer-Reviewed Original ResearchConceptsMiR-125b-5pObsessive-compulsive disorderObsessive-compulsive disorder patientsMiR-132Expression level of miR-132Dopamine levelsMiR-125b-5p expressionMiR-21-3pLevel of miR-132Pathogenesis of obsessive-compulsive disorderObsessive-compulsive disorder groupPlasma serotoninMiR-21Levels of serotoninBiomarker miRNAsPersistent obsessionsPsychiatric disordersSerotonin levelsExpression levelsSerotoninDopamineNo significant differenceFemale patientsReal-time PCRMiRNAsMapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis
Doğan M, Guloksuz S. Mapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis. ALPHA PSYCHIATRY 2025, 26: 44314. PMID: 40630888, PMCID: PMC12231412, DOI: 10.31083/ap44314.Peer-Reviewed Original ResearchClinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients
Leppanen J, Kieseppä V, Eskelinen S, Säynäjäkangas V, Rutten B, Gülöksüz S, Halt A, Riipinen P, Díaz-Caneja C, Kelleher I. Clinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients. Psychiatry Research 2025, 351: 116606. PMID: 40578224, DOI: 10.1016/j.psychres.2025.116606.Peer-Reviewed Original ResearchConceptsPsychosis symptomsTransdiagnostic markerPsychiatric inpatientsSeverity of psychosis symptomsSeverity of depressive symptomsAdolescent psychiatric inpatientsSchizophrenia spectrum diagnosisObsessive-compulsive disorderSeverity of depressionPsychiatric inpatient careMarkers of illness severityDuration of readmissionsAdolescent inpatientsSpectrum diagnosisConduct disorderPsychiatric diagnosisDepressive symptomsEating DisordersPsychosisSubstance useInpatient admissionsIllness severityClinical predictorsCumulative durationInpatientsExploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights
Wu X, Parekh P, Lin B, Pries L, Guloksuz S, Rutten B, Andreassen O, Linden D, van der Meer D. Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights. Schizophrenia Bulletin 2025, sbaf096. PMID: 40579369, DOI: 10.1093/schbul/sbaf096.Peer-Reviewed Original ResearchDiffusion tensor imagingBrain measuresPolygenic scoresRs-fMRIPolygenic overlapResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingGenome-wide association study summary statisticsLinkage disequilibrium score regressionConcordant effect directionsConjunctional false discovery rateSNP-based heritabilityFunctional brain featuresBrain imaging phenotypesSchizophreniaBrain structuresFunctional connectivityBrain phenotypesGenetic overlapScore regressionBrain featuresComplex genetic relationshipsRs-fMRI measuresIndividual locus levelCausal variantsLinking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study.
Andreu-Bernabeu Á, González-Peñas J, Mora A, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Santos J, Jiménez-López E, Arrojo M, Carracedo A, Parellada M, Maric N, Atbaşoğlu C, Üçok A, Alptekin K, Saka M, Pries L, O'Donovan M, van Os J, Rutten B, Delespaul P, Guloksuz S, Arango C, Díaz-Caneja C. Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study. The British Journal Of Psychiatry 2025, 1-9. PMID: 40519115, DOI: 10.1192/bjp.2025.100.Peer-Reviewed Original ResearchGene-environment interactionsGenetic riskSchizophrenia spectrum disordersAdverse mental health outcomesGenetic liabilityAssociated with higher oddsPolygenic risk scoresIdentification of high-risk individualsMental health outcomesRelative excess riskHigh-risk individualsEU-GEILogistic regression modelsHealth outcomesExcess riskHigher oddsPrevention strategiesVulnerable populationsRisk scoreRegression modelsLonelinessEarly identificationLong-term effectsWorsening symptomsAssociated with psychosisDecision-making on an AI-supported youth mental health app: A multilogue among ethicists, social scientists, AI-researchers, biomedical engineers, young experiential experts, and psychiatrists
Horstkötter D, Kanne M, Karbouniaris S, Lazrak N, Bulgheroni M, Sheltawy E, Giani L, La Gamba M, Pujadas E, Camacho M, Royle F, Baggetto I, Gülöksüz S, Rutten B, van Os J. Decision-making on an AI-supported youth mental health app: A multilogue among ethicists, social scientists, AI-researchers, biomedical engineers, young experiential experts, and psychiatrists. Journal Of Responsible Technology 2025, 22: 100119. DOI: 10.1016/j.jrt.2025.100119.Peer-Reviewed Original ResearchYouth mental health careMental health careMental health appsMental health expertsHealth appsHealth careSocial scientistsDecision-makingEthical challengesDecision-making processImpact of AIHealth expertsAI developmentHuman decision-makingPsychiatristsEthicistsTransdisciplinary teamFunding phaseDocument analysisExpertsTeam of researchersCareDecisionHuman relationshipsMultilogueMinimum data standards for schizophrenia and the EnvironmenT (MINDSET) research harmonization exercise
Crossley N, Gülöksüz S. Minimum data standards for schizophrenia and the EnvironmenT (MINDSET) research harmonization exercise. Schizophrenia Research 2025, 281: 216-217. PMID: 40398099, DOI: 10.1016/j.schres.2025.05.009.Peer-Reviewed Original Research