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    Silvio Inzucchi, MD

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    About

    Titles

    Professor of Medicine (Endocrinology)

    Biography

    Dr. Inzucchi received his undergraduate degree from Fordham University in New York City and his M.D. degree from Harvard Medical School in Boston, Massachusetts. He completed his residency in Internal Medicine and his post-doctoral Fellowship in Endocrinology and Metabolism at Yale-New Haven Hospital, in New Haven, Connecticut, USA. He is currently Professor of Medicine at the Yale University School of Medicine in New Haven, where he serves as Clinical Chief of the Section of Endocrinology, Medical Director of the Yale Diabetes Center, and Program Director of the Endocrinology & Metabolism Fellowship.

    Dr. Inzucchi has been an invited lecturer both nationally and internationally on many topics, most pertaining to clinical diabetes management. He has authored or co-authored more than 500 manuscripts, chapters, monographs, and abstracts, some published in the most prestigious medical journals, including the New England Journal of Medicineand JAMA. A former member of the editorial board of Diabetes Careand Associate Editor of the Journal of Clinical Endocrinology and Metabolism, Dr. Inzucchi served as co-chair of the writing group for the 2012 and 2015 ADA-EASD Position Statements on the Management of Hyperglycemia in Type 2 Diabetes.

    His current research interests include pharmacological antihyperglycemic therapy in both the inpatient and outpatient settings; and the link between type 2 diabetes, insulin resistance, and cardiovascular complications. He has held leadership roles in several large clinical trials related to diabetes medications and their cardiovascular impact.

    Dr. Inzucchi also has a large academic clinical practice involving a wide spectrum of patients with endocrine diseases, with a focus on diabetes and pituitary and adrenal diseases.

    Last Updated on April 07, 2025.

    Appointments

    Other Departments & Organizations

    Education & Training

    MD
    Harvard University (1985)
    BS
    Fordham University (1981)

    Research

    Overview

    Medical Research Interests

    Atherosclerosis; Diabetes Mellitus; Endocrinology; Hyperglycemia; Insulin Resistance; Metabolism

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Silvio Inzucchi's published research.

    Publications

    2026

    • Effect of In-Hospital Initiation of Dapagliflozin on Decongestion in Patients Hospitalized for Heart Failure An Analysis of the DAPA ACT HF-TIMI 68 Trial
      Small A, Patel S, Thomas C, Palazzolo M, Bělohlávek J, Desai A, Drożdż J, Inzucchi S, McMurray J, Merkely B, O'Meara E, Verma S, Wiviott S, Sabatine M, Berg D. Effect of In-Hospital Initiation of Dapagliflozin on Decongestion in Patients Hospitalized for Heart Failure An Analysis of the DAPA ACT HF-TIMI 68 Trial. JACC Heart Failure 2026, 103366. PMID: 42669075, DOI: 10.1016/j.jchf.2026.103366.
      Peer-Reviewed Original Research
    • Dapagliflozin in Patients With Heart Failure Across the Care Spectrum A Meta-Analysis of DAPA-HF, DELIVER, and DAPA ACT HF-TIMI 68
      Berg D, Vaduganathan M, Docherty K, Bellavia A, Murphy S, Claggett B, Desai A, Inzucchi S, Patel S, Wiviott S, Solomon S, McMurray J, Sabatine M. Dapagliflozin in Patients With Heart Failure Across the Care Spectrum A Meta-Analysis of DAPA-HF, DELIVER, and DAPA ACT HF-TIMI 68. JACC Heart Failure 2026, 14: 103232. PMID: 42547169, DOI: 10.1016/j.jchf.2026.103232.
      Peer-Reviewed Original Research
    • Oral semaglutide and CV benefits in the SOUL trial: how do baseline or changes in HbA1c and BMI affect clinical outcomes?
      Inzucchi S, Ghani R, Deanfield J, Emerson S, Engelmann M, Hovingh G, Jeppesen O, Kellerer M, Mandavya K, Mann J, Marx N, Mathieu C, McGuire D, Mohan V, Mulvagh S, Pop-Busui R, Poulter N, Rasouli N, Ripa M, Roman G, García R, Shechter M, Buse J. Oral semaglutide and CV benefits in the SOUL trial: how do baseline or changes in HbA1c and BMI affect clinical outcomes? The Journal Of Clinical Endocrinology & Metabolism 2026, dgag290. PMID: 42478869, DOI: 10.1210/clinem/dgag290.
      Peer-Reviewed Original Research
    • Sodium Glucose Cotransporter-2 Inhibitors are Not Associated with Amputation After Lower Extremity Revascularization in Patients with Diabetes
      Alappan U, Chetty A, Carter W, Wells N, Alameddine D, Inzucchi S, Guzman R, Ochoa Chaar C. Sodium Glucose Cotransporter-2 Inhibitors are Not Associated with Amputation After Lower Extremity Revascularization in Patients with Diabetes. Annals Of Vascular Surgery 2026, 130: 415-424. PMID: 42162856, DOI: 10.1016/j.avsg.2026.04.067.
      Peer-Reviewed Original Research
    • Podcast Episode 2: Heart Failure Management in Patients with Diabetes for Endocrinologists, Primary Care Physicians, and Noncardiologist Clinicians: Focus on SGLT2 Inhibitors
      Desai N, Inzucchi S, Wright E. Podcast Episode 2: Heart Failure Management in Patients with Diabetes for Endocrinologists, Primary Care Physicians, and Noncardiologist Clinicians: Focus on SGLT2 Inhibitors. Diabetes Therapy 2026, 17: 807-814. PMID: 41984371, PMCID: PMC13253893, DOI: 10.1007/s13300-026-01856-6.
      Commentaries, Editorials and Letters
    • Semaglutide and Cardiovascular Outcomes According to Baseline Aspirin Use: Analyses of the SOUL and SELECT Trials
      Müller‐Wieland D, McGuire D, Lincoff A, Buse J, Mann J, Inzucchi S, Pop‐Busui R, Mulvagh S, Emerson S, Poulter N, Deanfield J, Marx N. Semaglutide and Cardiovascular Outcomes According to Baseline Aspirin Use: Analyses of the SOUL and SELECT Trials. Diabetes Obesity And Metabolism 2026, 28: 6413-6416. PMID: 41969169, PMCID: PMC13243933, DOI: 10.1111/dom.70752.
      Commentaries, Editorials and Letters
    • Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes
      Pop-Busui R, Rasmussen S, Deanfield J, Buse J, Marx N, Mulvagh S, Inzucchi S, Mann J, Emerson S, Poulter N, Engelmann M, Hovingh G, Bayer Tanggaard K, Birkenfeld A, Connelly K, Haluzik M, Cavender M, Kellerer M, Jhund P, Gregersen S, Nielsen O, Lam C, McGuire D, Schelde P, Amod A, Mankovsky B, Desouza C, Gorgojo-Martinez J, Arechavaleta R, Tu S, Francisco J, Sánchez García R, Chun Chung Chow F, Watada H, Yoon K, Perez Manghi F, Pozzi J, Lorenzatti A, Visco V, Piskorz D, Nardone L, Chahin M, Bustamante Labarta M, Luquez C, MacKinnon I, Pieber T, Prager R, Fließer-Görzer E, Ebenbichler C, Fasching P, Mathieu C, De Block C, Duyck F, Heyns E, Lapauw B, Turatti L, Franco D, Rea R, Kurtz Lisboa H, Salles J, Saraiva J, Fonseca A, Vidotti M, Leite S, Aggarwal N, Bajaj H, Schlosser R, Noronha L, Pedersen S, Tellier G, Weisnagel J, Beca S, Alasaad H, Punthakee Z, Mancini J, Tytus R, Ransom T, Husain M, Tsoukas M, Ji L, Liu J, Yuan G, Ye X, Dong X, Bian F, Angelo Cadena Bonfanti A, Hernandez Erazo I, Hernández Ruiz E, Gómez Mesa J, Canecki-Varzic S, Vucak Loncar J, Simegi-Djekic V, Ticinovic Kurir T, Tusek S, Rahelic D, Marusic S, Kruljac I, Fabris Vitkovic D, Oznerova M, Vrkoc J, Doležalová B, Jankovec Z, Olsovsky J, Zemanova J, Kyselova P, Šmahelová A, Olsen A, Mikkelsen D, Egstrup K, Pedersen-Bjergaard U, Potier L, Borot S, Gaborit B, Monier A, Pradignac A, Verges B, Larroumet A, Thuan J, Lüdemann J, Esser M, Kahrmann G, Kempe H, Koch T, Axthelm C, Paschen B, Rose L, Schaum T, Schulze J, Staudenmeyer A, Wenzl-Bauer V, Ma R, Thomas N, Mohan V, Reddy V, Rao P, Sahay R, Singh J, Prakash A, Tandon N, Marwah T, Chaudhury T, Ghosh S, Kanungo A, Mittal N, Jacob J, Chadha M, Bhagwat N, Jain S, Thulaseedharan N, Girithara G, Desai A, Sharma S, Murthy S, Sethi B, Kadam Y, Kesavadev J, Daxini B, Chawla R, Gopalakrishnan U, Baruah M, Reddy S, Suryanarayana K, Singh K, Saboo B, Aharon-Hananel G, Hochberg I, Sofer Y, Tirosh A, Shimon I, Vishlitzky V, Bashkin A, Tsur A, Shechter M, Andreozzi F, Setola E, Consoli A, Lupoli R, Genovese S, Maranghi M, Lauro D, Citarrella R, Fadini G, Murdolo G, Di Carlo A, Giorgino F, Buscemi S, Hanaoka K, Osonoi T, Ohashi H, Ezaki H, Yuki H, Kiyosue A, Hata Y, Sugawara M, Domae H, Iwata H, Nishida Y, Igarashi M, Fujino S, Oiwa A, Oh F, Sueyoshi A, Murakami T, Tanaka M, Idogaki A, Onaka H, Mizote I, Doi M, Ebisui O, Tanabe M, Natsuaki M, Jinnouchi H, Nakamura S, Wan Mohamed W, Yahaya N, Ratnasingam J, Ong T, Mohamad M, Yusoff Azmi Merican N, Abdul Ghani R, Adam N, Fam T, Tan F, Morales Villegas E, Gonzalez-Galvez G, Espinoza Peralta D, Medina Pech C, García Ulloa A, Laviada Molina H, Banda Elizondo R, Garza Ruiz J, García Cantú E, van Bemmel T, de Valk H, Kooy A, Lieverse L, Landewe-Cleuren S, Hoogenberg K, van Raalte D, Jebbink M, Oldenburg-Ligtenberg C, Abbink-Zandbergen E, Mihai B, Crisan C, Filip I, Busegeanu M, Roman G, Mot A, Nicoara A, Anghel V, Pletea N, Suciu M, Strajer D, Cernea S, Zilov A, Kobalava Z, Ruyatkina L, Suplotova L, Sergeeva-Kondrachenko M, Yanovskaya M, Kargina L, Ignatyeva A, Astamirova K, Zalevskaya A, Zagrebelnaya O, Frolova E, Peskov A, Mishchenko (Golinskaya) O, Otroshchenko O, Gaysina L, Shabelnikova O, Saprina T, Lysenko T, Kunitsyna M, Zyangirova S, Lalic N, Lalic K, Beljic Zivkovic T, Kikovic S, Djukic A, Pesic M, Dimic D, Stokic E, Mitrovic M, Polovina S, Djordjevic M, Sosovec D, Pella D, Donicova V, Hanackova Prasekova S, Koleny D, Culak J, Cerna K, Hundza V, Gmitrov J, Lacka J, Plasil R, Bacus H, Bhorat Q, Joshi P, Lakha D, Makan V, Ntusi N, Padayachee T, Seeber M, Pillay D, Joshi M, Mayet L, Lee J, Kim S, Min K, Kang E, Lee W, Choi S, Lee C, López Suárez A, García Ordóñez M, García Quintana A, Mazón Ramos P, Cigarrán S, Barrios C, Soto González A, Jodar E, Delgado Lista J, Morales Portillo C, Montalbán Carrasco C, Tinahones F, Huang C, Chen S, Buranasupkajorn P, Sriwijitkamol A, Buranapin S, Suwanagool A, Tantiwong P, Boonyavarakul A, Benjachareonwong S, Leelawattana R, Vathesatogkit P, Deerochanawong C, Sonmez Y, Oguz A, Tabak O, Kocak M, Sariakcali B, Bayram F, Guclu M, Gurkan E, Kebapci N, Comlekci A, Acibucu F, Ahbab S, Bilen H, Urbanovych A, Kuskalo P, Bondarets I, Petrosyan O, Pashkovska N, Oleksyk O, Kaydashev I, Maliar K, Myshanych G, Bain S, Black D, Johnston P, Dang C, Dhatariya K, English P, Field B, Grimmer P, Gunstone A, Ray S, Tatovic D, Kernohan A, Lindsay R, Mcknight J, Park A, Patel D, Philip S, Randeva H, Sathyapalan T, Turner W, Wyatt N, Allison D, Awasty V, Ayele E, Bajaj C, Budoff M, Busch R, Casaubon L, Chaidarun S, Chochinov R, Chu J, Daboul N, Dang A, Everhart B, Arambasick J, Fink R, Fitz-Patrick D, Fogarty C, Gilbert M, Johnson D, Krishnasamy S, Lane W, Nakhle S, Levenson D, O’Donnell P, Weiss D, Risser J, Wierum C, Sivalingam K, Gupta D, Philis-Tsimikas A, Pratley R, Mirza L, Snyder B, Rasouli N, Porter J, Ledesma G, Powell T, Tandron I, Lingvay I, Reed J, Patel M, Lovre D, Chaicha-Brom T, Jantzi C, Brautigam D, Bao S, Mbogua C, Zemel L, Hasan S, Rosenstock J, Tran H, Poremba J, Baker C, Prier K, Chilka S, Agaiby J, Condit J, Eagerton D, Huffman D, Cornett G, Traylor H, Brinson C, Bays H, Jerkins T, Nicol P, Siddiqui I, Hewitt M, Odugbesan A, Lillestol M, Thrasher J, Gandy W, Pant N, Nagelberg S, Cannon K, Anderson M, Bhargava A, Doshi A, Jardula M, Montero M, Purighalla R, Warren M, Harris K, Jackson R, Khaira A, Gonzalez-Orozco L, Gagianas P, Pantalone K, Murray A. Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes. JAMA Internal Medicine 2026, 186: 426-436. PMID: 41627802, PMCID: PMC12865694, DOI: 10.1001/jamainternmed.2025.7774.
      Peer-Reviewed Original Research
    • Effect of Oral Semaglutide on Cardiovascular Outcomes in Type 2 Diabetes by Extent of Vascular Disease
      Cavender M, Marx N, Mulvagh S, Deanfield J, Buse J, Inzucchi S, Pop-Busui R, Mann J, Emerson S, Poulter N, Engelmann M, Hovingh G, Lorenzatti A, Oguz A, Saraiva J, Garcia R, Hoff S, Musinga D, Bonaca M, Arslan E, McGuire D, Group S. Effect of Oral Semaglutide on Cardiovascular Outcomes in Type 2 Diabetes by Extent of Vascular Disease. Journal Of The American College Of Cardiology 2026, 87: 1369-1373. PMID: 42552888, DOI: 10.1016/j.jacc.2025.12.071.
      Peer-Reviewed Original Research
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    Clinical Care

    Overview

    Silvio E. Inzucchi, MD, director of the Yale Medicine Diabetes Center, treats patients who suffer from diabetes as well as pituitary and adrenal disorders. “Endocrinology is fascinating, and we are usually able to help patients improve their quality of life through multidisciplinary care and academic approaches to endocrine conditions,” he says.

    Dr. Inzucchi is a professor or medicine (endocrinology) at Yale School of Medicine and the clinical director of the section of endocrinology. In his research, Dr. Inzucchi, studies the cardiovascular effects of diabetes medications and glucose management in the hospital. Named a “top doctor” locally and nationally, Dr. Inzucchi has also received Yale’s David J. Leffell Prize for Clinical Excellence. The prize is given to individuals who demonstrate the highest level of clinical expertise, commitment to teaching and compassion for patients.

    He says he has developed an effective personal approach to treating patients, carefully honed over 30 years at Yale. It includes being on top of the latest advances, but also responding to each patient’s individual needs. “I like to try to draw people out in terms of who they are, what’s important to them, their life experiences and their family. Such an approach resonates with patients because they don’t want to be seen as a patient, they want to be treated as a person,” he says.

    Clinical Specialties

    Endocrinology; Diabetes Medicine & Management

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    Board Certifications

    • Internal Medicine

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1988

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