Shannon Kay, MD
Assistant ProfessorCards
About
Research
Publications
Featured Publications
Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez J. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 884-896. PMID: 40587876, DOI: 10.1165/rcmb.2024-0565oc.Peer-Reviewed Original ResearchSex-biased gene expressionClinical featuresGene expressionType 2 inflammationClinical features of asthmaFeatures of asthmaAssociated with differential gene expressionExpression levelsImmune dysfunctionLocal validation cohortAdult patientsGene expression databaseValidation cohortImmune cellsClinical correlatesDifferential gene expressionGene expression differencesLymphocyte proliferationAllergic responsesAdult subjectsGene expression effectsGenetic polymorphismsImmune allergic responsesBlood samplesFemale genomes
2025
The Role of Non-coding RNAs in Asthma T2-high and T2-low Endotypes
Zielonka J, Kay S, Chupp G, Gomez J. The Role of Non-coding RNAs in Asthma T2-high and T2-low Endotypes. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3430-a3430. DOI: 10.1164/ajrccm.2025.211.abstracts.a3430.Peer-Reviewed Original Research
2024
Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records.
Li H, Huston J, Zielonka J, Kay S, Sauler M, Gomez J. Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2024, 11: 611-623. PMID: 39423339, PMCID: PMC11703024, DOI: 10.15326/jcopdf.2024.0556.Peer-Reviewed Original ResearchElectronic health recordsMachine learningAcute exacerbation of COPDAdoption of electronic health recordsHealth recordsMachine learning implementationElectronic health record dataImplementation of MLEHR-derived dataML implementationChronic obstructive pulmonary disease subgroupCOVID-19 cohortSevere acute exacerbation of COPDClinical careExacerbation of COPDAcute exacerbationRetrospective cohort of patientsLearning implementationSeverity of acute exacerbations of COPDMachineRelevant subgroupsRetrospective cohortImplementationCohortCohort of patients
2023
Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank
Li B, Wang Y, Wang Z, Li X, Kay S, Chupp G, Zhao H, Gomez J. Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank. ERJ Open Research 2023, 9: 00291-2023. PMID: 37650091, PMCID: PMC10463033, DOI: 10.1183/23120541.00291-2023.Peer-Reviewed Original ResearchGenome-wide association studiesGenetic architectureGenetic correlation analysisUK BiobankGWAS resultsTranscription factorsInterleukin-4 SignalingBlood eosinophil countsAssociation studiesDoctor-diagnosed asthmaSignificant variantsEosinophil countEuropean ancestryTraitsPathwayGenetic linkType 2 immune responsesType 2 inflammationSignalingCritical associationImmune responseHeterogeneous diseaseTAGCSevere asthmaTherapeutic interventionsMachine Learning Prediction of Severe Asthma and COPD Hospital Readmission
Li H, Lopez K, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Machine Learning Prediction of Severe Asthma and COPD Hospital Readmission. 2023, a4831-a4831. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4831.Peer-Reviewed Original ResearchDeep learning prediction of hospital readmissions for asthma and COPD
Lopez K, Li H, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Deep learning prediction of hospital readmissions for asthma and COPD. Respiratory Research 2023, 24: 311. PMID: 38093373, PMCID: PMC10720134, DOI: 10.1186/s12931-023-02628-7.Peer-Reviewed Original Research
2021
An Overview of Sex and Gender in Pulmonary and Critical Care Medicine
Kay S, Pisani MA. An Overview of Sex and Gender in Pulmonary and Critical Care Medicine. Clinics In Chest Medicine 2021, 42: 385-390. PMID: 34353445, DOI: 10.1016/j.ccm.2021.04.001.Peer-Reviewed Original ResearchSex-Specific Gene Expression in the Sputum of Patients with Asthma
Kay S, Chupp G, Gomez J. Sex-Specific Gene Expression in the Sputum of Patients with Asthma. 2021, a1383-a1383. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1383.Peer-Reviewed Original ResearchThe Patient Care Ownership Scale: External Validation of an Instrument that Measures Patient Care Ownership Among Internal Medicine Trainees—a Multi-Institutional Study
Djulbegovic M, Kulkarni SA, Chen KL, Canavan M, White MA, McGuire WC, Shan S, Reddy R, Kay S, Fraenkel L. The Patient Care Ownership Scale: External Validation of an Instrument that Measures Patient Care Ownership Among Internal Medicine Trainees—a Multi-Institutional Study. Journal Of General Internal Medicine 2021, 36: 3680-3688. PMID: 33782886, PMCID: PMC8642535, DOI: 10.1007/s11606-021-06703-x.Peer-Reviewed Original ResearchConceptsItem reductionIntensive care unitMedicine residentsCross-sectional studyMulti-institutional studyPARTICIPANTSInternal medicine residentsPositive associationInternal medicine traineesOwnership scaleInternal medicine residentsCare unitSignificant positive associationMain MeasuresWeKey ResultsOfPatient care ownershipEligible residentsPatient careSignificant associationBivariate analysisInpatient rotationsResident physiciansMedicine traineesCronbach's αExternal validationDecision ownership
2019
Interstitial pneumonia with autoimmune features (IPAF): a clinical entity?
Mari P, Kay S, Belloli E, Salisbury M, Sheth J, Holtze C, Wang B, Myers J, Konopka K, Lagstein A, Kazerooni E, Chughtai A, Vummidi D, Nagaraja V, Khanna D, Flaherty K, Richeldi L, White E. Interstitial pneumonia with autoimmune features (IPAF): a clinical entity? 2019, pa1735. DOI: 10.1183/13993003.congress-2019.pa1735.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Clinical Specialties
Pulmonary Critical Care ; Asthma
Board Certifications
Pulmonary Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2023
Critical Care Medicine (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2023
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
News
News
- October 03, 2025Source: HCPLive
Yale Researchers Uncover Biological Differences in Asthma Between Males and Females
- September 03, 2025
Yale Researchers Uncover Biological Differences in Asthma Between Males and Females
- March 10, 2025
Britto-Leon Named Yale Pulmonary and Critical Care Fellowship Director
- January 08, 2024
Using AI to Identify High-Risk Patients With Asthma and COPD
Get In Touch
Contacts
Email
Mailing Address
Pulmonary, Critical Care & Sleep Medicine
The Anlyan Center , 300 Cedar Street
New Haven, CT 06519
United States
Locations
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