Ryland Mortlock
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Biography
Ryland is a 4th year MD-PhD student pursuing his PhD in Genetics in the lab of Keith Choate, MD, PhD. His research focuses on applying animal models, spatial transcriptomics, and three-dimensional cell culture systems to study genetic skin diseases, specifically exploring how barrier dysfunction and cellular interactions contribute to inflammation in epidermal differentiation disorders. Prior to coming to Yale, Ryland graduated in 2019 from the University of Southern California with a degree in Chemical Engineering and completed a two-year Postbaccalaureate Research Fellowship at the National Institutes of Health.
Last Updated on September 07, 2024.
Education & Training
- Postbaccalaureate Research Fellowship
- National Heart Lung Blood Institute, National Institutes of Health (2021)
- BS
- University of Southern California, Viterbi School of Engineering, Chemical Engineering (Biochemical Emphasis) (2019)
Research
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Overview
Medical Research Interests
Biomedical Engineering; Data Science; Dermatology; Genetics; Genomics; Hematology; Nanotechnology; Systems Biology
ORCID
0000-0001-9666-4394
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ryland Mortlock's published research.
Publications Timeline
A big-picture view of Ryland Mortlock's research output by year.
Research Interests
Research topics Ryland Mortlock is interested in exploring.
Keith Choate, MD, PhD
Xingyuan Jiang, MD, MBBS
Jeffrey Cohen, MD, MPH
Jonathan Leventhal, MD
Christine Ko, MD
Christopher Bunick, MD, PhD
27Publications
146Citations
Dermatology
Publications
Featured Publications
Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling
Mortlock RD, Georgia SK, Finley SD. Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling. Cellular And Molecular Bioengineering 2020, 14: 15-30. PMID: 33633812, PMCID: PMC7878662, DOI: 10.1007/s12195-020-00647-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBeta-cell massBeta cellsInsulin-producing beta cellsReceptor internalizationContext of pregnancyPrimary beta cellsJAK-STATPancreatic beta cellsBeta cell expansionBeta-cell survivalSTAT5 activationProlactin receptor signalingINS-1 cellsGestational diabetesInsulin resistanceReceptor upregulationGlucose homeostasisBiphasic responseThe spectrum of cutaneous immune-related adverse events in patients with skin of color
Belzer A, Mortlock R, Olamiju B, Olino K, Cohen J, Leventhal J. The spectrum of cutaneous immune-related adverse events in patients with skin of color. Journal Of The American Academy Of Dermatology 2022, 88: 1156-1158. PMID: 36470309, PMCID: PMC10838520, DOI: 10.1016/j.jaad.2022.11.051.Peer-Reviewed Original ResearchCitationsAssessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology
Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsAtopic dermatitisSkin diseasesInflammatory skin diseaseInflammatory skin conditionImmunologic biomarkersImmune biomarkersPersonalized medicineInflammatory dermatosesImmunologic approachesTherapy selectionSkin conditionsSingle-cell RNA sequencingMolecular profilingBiomarkersTissue stainingPsoriasisDermatitisDiseaseDermatologyRNA sequencingMedicineCurettageDermatosesTherapyPersonalized classificationInterrogation of clonal tracking data using barcodetrackR
Espinoza D, Mortlock R, Koelle S, Wu C, Dunbar C. Interrogation of clonal tracking data using barcodetrackR. Nature Computational Science 2021, 1: 280-289. PMID: 37621673, PMCID: PMC10449013, DOI: 10.1038/s43588-021-00057-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProgenitor cellsClonal tracking studiesProgenitor cell outputContext of genesHSPC transplantCellular compartmentsCellular outputStandardized analytical frameworkLineage relationshipsHematopoietic stemClonal dynamicsHSPC gene therapyLineage reconstitutionR packageVector genotoxicityCellsShiny appTumor cellsClonal patternGene therapyTracking dataDiverse toolsGenesQuantitative insightsValuable insightsAutosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma
Jiang X, Mortlock R, Lomakin I, Zhou J, Hu R, Cossio M, Bunick C, Choate K. Autosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma. British Journal Of Dermatology 2025, 192: 896-906. PMID: 39913669, PMCID: PMC12036768, DOI: 10.1093/bjd/ljaf049.Peer-Reviewed Original ResearchCitationsConceptsProgressive symmetric erythrokeratodermaAmino acidsGenetic variantsPathogenic variantsNF-kB signalingPalmoplantar keratodermaSpatial transcriptomicsPatient keratinocytesWhole-exome sequencingSLURP1 expressionIn silico predictionVariant consequencesSignal peptideMal de MeledaExome sequencingSecreted proteinsHealthy control cellsInnate immune activationIn silico modelsPhenotypic spectrumControl cellsConfirmed with mass spectrometryAminoAutosomal dominant transmissionTranscriptomeImpact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Lee B, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, DeRavin S, Shin T, Hong S, Dunbar C. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell 2024, 31: 788. PMID: 38599215, PMCID: PMC11114628, DOI: 10.1016/j.stem.2024.04.005.Peer-Reviewed Original ResearchCitationsAltmetricTissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining
Mortlock RD, Wu C, Potter EL, Abraham DM, Allan DSJ, Hong SG, Roederer M, Dunbar CE. Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining. Frontiers In Immunology 2022, 12: 772332. PMID: 35095846, PMCID: PMC8790741, DOI: 10.3389/fimmu.2021.772332.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNatural killer cellsNK cellsKiller cellsPeripheral bloodIntravascular stainingHuman NK cell biologyRhesus macaquesNK cell subsetsNK cell biologyTissue distributionNon-lymphoid tissuesNK compartmentLymph nodesCell subsetsAnimal modelsRM tissuesCD16Perivascular compartmentTrafficking patternsTissueBloodHigher proportionStainingCellsDifferent subsets
2025
LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis
Bacchiocchi A, Mak M, Khan Z, Gong X, Sznol M, Na Z, Su H, Chan L, Yan Q, Zhao D, Mortlock R, Knight J, Slavoff S, Halaban R. LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis. Oncogene 2025, 44: 3974-3984. PMID: 40885854, PMCID: PMC12500468, DOI: 10.1038/s41388-025-03538-2.Peer-Reviewed Original ResearchAltmetricConceptsDegradation of ubiquitinated proteinsActin-related proteinsActin cytoskeleton organizationUbiquitin-proteasome systemSrc tyrosine kinaseAnchorage-independent growthNormal cell survivalCargo adapterActin organizationProximity biotinylationCytoskeleton organizationLC-MS/MS proteomicsLeucine zipperProteasome systemUbiquitinated proteinsCo-ImmunoprecipitationTargeting Pyk2Cell spreadingMelanoma cellsEnvironmental stressGrowth advantageMolecular characterizationCell migrationCell survivalLZTR1A recurrent de novo damaging variant in EMP2 causes progressive symmetric erythrokeratoderma
Jiang X, Mortlock R, Pironon N, Zhou J, Hu R, Liu W, Acosta A, Shwayder T, Hovnanian A, Lifton R, Choate K. A recurrent de novo damaging variant in EMP2 causes progressive symmetric erythrokeratoderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509896122. PMID: 40758889, PMCID: PMC12358830, DOI: 10.1073/pnas.2509896122.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAssociated with focal adhesion kinaseEpidermal growth factor receptorRecurrent de novo missense variantFocal adhesion kinaseGain-of-function mechanismActivation of signaling pathwaysSingle-cell spatial transcriptomicsReceptor tyrosine kinasesMissense variantsMyelin protein 22Sites of wound healingTetraspan proteinProgressive symmetric erythrokeratodermaGenetic investigationsSignaling pathwayEpidermal integrityTyrosine kinaseSpatial transcriptomicsEpidermal differentiationEpidermal growth factor receptor inhibitorsGrowth factor receptorSkin disordersMyelin proteinsProtein 22Kinase0571 Linear epidermal nevus caused by a novel mosaic heterozygous PTPN11 variant
Jiang X, Chen T, Hu R, Mortlock R, Ko C, Choate K. 0571 Linear epidermal nevus caused by a novel mosaic heterozygous PTPN11 variant. Journal Of Investigative Dermatology 2025, 145: s99. DOI: 10.1016/j.jid.2025.06.578.Peer-Reviewed Original Research
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