2023
Sensory neurons promote immune homeostasis in the lung
Tamari M, Del Bel K, Ver Heul A, Zamidar L, Orimo K, Hoshi M, Trier A, Yano H, Yang T, Biggs C, Motomura K, Shibuya R, Yu C, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory J, Hasson D, Dai J, Chang R, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner J, Bogunovic D, Hu H, Artis D, Turvey S, Kim B. Sensory neurons promote immune homeostasis in the lung. Cell 2023, 187: 44-61.e17. PMID: 38134932, PMCID: PMC10811756, DOI: 10.1016/j.cell.2023.11.027.Peer-Reviewed Original Research
2018
An evolutionarily conserved gene family encodes proton-selective ion channels
Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. An evolutionarily conserved gene family encodes proton-selective ion channels. Science 2018, 359: 1047-1050. PMID: 29371428, PMCID: PMC5845439, DOI: 10.1126/science.aao3264.Peer-Reviewed Original ResearchConceptsProton-selective ion channelIon channelsProton channelComparative transcriptome analysisTaste receptor cellsWidespread tissue distributionEvolutionary conservationEukaryotic cellsGene familyMurine geneTranscriptome analysisReceptor cellsElectrical signalingProton conductanceBroader roleMouse taste receptor cellsTissue distributionCellsOrthologsGenesSignalingProteinConservationPhysiologyFamily
2010
A proton current drives action potentials in genetically identified sour taste cells
Chang RB, Waters H, Liman ER. A proton current drives action potentials in genetically identified sour taste cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 22320-22325. PMID: 21098668, PMCID: PMC3009759, DOI: 10.1073/pnas.1013664107.Peer-Reviewed Original ResearchConceptsTaste cellsSour stimuliSour taste cellsAction potential firingSour taste transductionAcid stimuliGenetic ablation experimentsSuction electrode recordingsSour sensingSour cellsSubset of cellsAction potentialsPKD1L3 genesExpression of YFPResponsive cellsTaste cell membraneElectrode recordingsNumerous ion channelsTaste budsTaste transductionTargeted deletionSour transductionIon channels