2020
Vagal sensory neurons and gut-brain signaling
Yu CD, Xu QJ, Chang RB. Vagal sensory neurons and gut-brain signaling. Current Opinion In Neurobiology 2020, 62: 133-140. PMID: 32380360, PMCID: PMC7560965, DOI: 10.1016/j.conb.2020.03.006.Peer-Reviewed Original ResearchConceptsVagal sensory neuronsGut-brain signalingSensory neuronsGut-derived signalsTrans-synaptic tracingImmune controlVagus nerveImmunological disordersBrain pathwaysAnatomical basisNovel physiological functionCellular mechanismsActivity recordingsNeural activity recordingNeuronsRecent findingsNew gutPhysiological functionsGutGut systemSingle-cell genomic analysisSignalingAfferentsNervePsychological regulation
2018
An evolutionarily conserved gene family encodes proton-selective ion channels
Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. An evolutionarily conserved gene family encodes proton-selective ion channels. Science 2018, 359: 1047-1050. PMID: 29371428, PMCID: PMC5845439, DOI: 10.1126/science.aao3264.Peer-Reviewed Original ResearchConceptsProton-selective ion channelIon channelsProton channelComparative transcriptome analysisTaste receptor cellsWidespread tissue distributionEvolutionary conservationEukaryotic cellsGene familyMurine geneTranscriptome analysisReceptor cellsElectrical signalingProton conductanceBroader roleMouse taste receptor cellsTissue distributionCellsOrthologsGenesSignalingProteinConservationPhysiologyFamily