Reina Desrouleaux
Postgraduate AssociateAbout
Research
Publications
2025
The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis.
Zhang L, Han C, Shrestha M, Le J, Berger W, Huang Y, Desrouleaux R, Wang E, Nagy L, Yang X. The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis. Hepatology 2025 PMID: 40587778, DOI: 10.1097/hep.0000000000001445.Peer-Reviewed Original ResearchMetabolic dysfunction-associated fatty liver diseaseTrefoil factor 2O-GlcNAc transferaseGubra-amylin NASHParacrine factorsCD4+ T cell proliferationLiver diseaseCD4 T cellsTreatment of chronic liver diseaseT cell proliferationChemokine ligand-12Chronic liver diseaseDiet-induced mouse modelSpectrum of liver pathologyFatty liver diseaseNon-parenchymal cellsTh1/Th17 differentiationO-GlcNAc transferase expressionT cellsDiet-fed miceImmune cellsDisease progressionMouse modelIntercellular crosstalkLiver pathology
2024
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Ong Q, Lim L, Goh C, Liao Y, Chan S, Lim C, Kam V, Yap J, Tseng T, Desrouleaux R, Wang L, Ler S, Lim S, Kim S, Sobota R, Bennett A, Han W, Yang X. Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT. Nature Chemical Biology 2024, 21: 300-308. PMID: 39543398, PMCID: PMC12279475, DOI: 10.1038/s41589-024-01770-7.Peer-Reviewed Original ResearchO-GlcNAc transferaseO-GlcNAcLocalized to specific subcellular sitesResponse to insulin stimulationPost-translational modification of intracellular proteinsModification of intracellular proteinsO-GlcNAc signalingPost-translational modificationsTargeting O-GlcNAc transferaseSpatiotemporal controlMulticellular organismsOGT activityOrganelle functionO-GlcNAcylationSubcellular sitesMTORC activitySignal transductionIntracellular proteinsNutrient-sensing signalsCell signalingInsulin stimulationPlasma membraneGene expressionRegulatory mechanismsAkt phosphorylation