2009
The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes
Stewart AK, Vandorpe DH, Heneghan JF, Chebib F, Stolpe K, Akhavein A, Edelman EJ, Maksimova Y, Gallagher PG, Alper SL. The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes. American Journal Of Physiology - Cell Physiology 2009, 298: c283-c297. PMID: 19907019, PMCID: PMC2822494, DOI: 10.1152/ajpcell.00444.2009.Peer-Reviewed Original Research4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmbystoma mexicanumAmino Acid SequenceAmphibiansAnemia, Hemolytic, CongenitalAnimalsAnion Exchange Protein 1, ErythrocyteBicarbonatesBumetanideCell MembraneCell Membrane PermeabilityChloridesCloning, MolecularDNA Mutational AnalysisFemaleGlycophorinsHeterozygoteHumansHydrogen-Ion ConcentrationKineticsMaleMembrane PotentialsMiddle AgedMolecular Sequence DataMutation, MissenseOocytesOuabainOxalic AcidRubidium RadioisotopesSeverity of Illness IndexSodium Potassium Chloride Symporter InhibitorsSodium-Potassium-Exchanging ATPaseSulfatesXenopus laevis
2000
Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*
Lopes C, Gallagher P, Buck M, Butler M, Goldstein S. Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*. Journal Of Biological Chemistry 2000, 275: 16969-16978. PMID: 10748056, DOI: 10.1074/jbc.m001948200.Peer-Reviewed Original ResearchConceptsExternal potassium levelsGenomic structureUnique functional attributesProton blockIndependent molecular entitiesP domainMurine examplesFunctional attributesBiophysical propertiesPhysiological voltage rangePhysiological levelsPotassium channelsLeak conductanceMolecular entitiesSubunitsPotassium leak conductanceKCNK3Conductance