2024
A Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation
Fowler V, Ghosh A, Coffin M, Diaz D, Schulz V, Gallagher P. A Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation. Blood 2024, 144: 535-535. DOI: 10.1182/blood-2024-210773.Peer-Reviewed Original ResearchRegulation of F-actin assemblyF-actin assemblyF-actinATAC-peaksH3K27 acetylationN-terminal actin-binding domainErythroid differentiationEnucleated cellsActin-binding domainActin-nucleating factorsF-actin cablesActin-binding proteinsTerminal differentiationActin filament polymerizationC-terminal SH2Translation start siteAssemble F-actinFocal adhesion formationDetect F-actinIncreased chromatin accessibilityErythroid terminal differentiationMolecular regulatory mechanismsSpectrin membrane skeletonMRNA translational start siteReduced F-actin
2020
Comprehensive proteomic analysis of murine terminal erythroid differentiation
Gautier EF, Leduc M, Ladli M, Schulz VP, Lefèvre C, Boussaid I, Fontenay M, Lacombe C, Verdier F, Guillonneau F, Hillyer CD, Mohandas N, Gallagher PG, Mayeux P. Comprehensive proteomic analysis of murine terminal erythroid differentiation. Blood Advances 2020, 4: 1464-1477. PMID: 32282884, PMCID: PMC7160260, DOI: 10.1182/bloodadvances.2020001652.Peer-Reviewed Original ResearchConceptsTerminal erythroid differentiationErythroid differentiationProteomic dataMurine terminal erythroid differentiationTerminal differentiationOverall cellular contentComprehensive proteomic dataComprehensive proteomic analysisMurine erythroid cellsTerminal differentiation processMost biologic processesProteome levelComparison of murineHuman proteomeProteomic analysisTranscriptomic changesChromatin condensationProteomeErythroid cellsFundamental mechanismsRed cell disordersDifferentiation processErythroid progenitorsFriend erythroleukemiaCellular model