2024
Dexamethasone Targets E2F4 to Induce Erythroid Progenitor Renewal
Papoin J, Schulz V, Khan F, Barnes B, Lipton J, Steiner L, Narla M, Gallagher P, Blanc L. Dexamethasone Targets E2F4 to Induce Erythroid Progenitor Renewal. Blood 2024, 144: 1076. DOI: 10.1182/blood-2024-211687.Peer-Reviewed Original ResearchDiamond-Blackfan anemiaCD34+ cellsErythroid progenitorsSteroid responsivenessExpression of E2F4Peripheral bloodBone marrowE2F4 expressionDex treatmentCultured CD34+ cellsInherited bone marrow failure syndromeMechanisms of steroid responseSide effectsBone marrow failure syndromesDiamond-Blackfan anemia patientsBone marrow erythroid progenitorsIncreased expressionMechanisms of corticosteroid actionAssociated with side effectsIncreased risk of infectionMarrow failure syndromesResponse to steroidsGene promoterSerum-free culture systemMarrow erythroid progenitors
2014
Pomalidomide Modulates Transcription Networks Regulating Human Erythropoiesis and Globin Switching: Implications for Treatment of Hemoglobinopathies
Dulmovits B, Appiah-Kubi A, Papoin J, Gould M, An X, Mohandas N, Gallagher P, Lipton J, Liu J, Blanc L. Pomalidomide Modulates Transcription Networks Regulating Human Erythropoiesis and Globin Switching: Implications for Treatment of Hemoglobinopathies. Blood 2014, 124: 1375. DOI: 10.1182/blood.v124.21.1375.1375.Peer-Reviewed Original ResearchSickle cell diseaseWestern blot analysisΓ-globin productionSide effectsDay 6Painful vaso-occlusive crisesSecond-generation immunomodulatory drugMay-Grunwald Giemsa stainingVaso-occlusive crisisSignificant side effectsQRT-PCRCurrent treatment approachesHbF productionErythroid differentiationBlot analysisFlow cytometric analysisRed cell sicklingMechanism of actionImmunomodulatory drugsNormal samplesPeripheral bloodPharmacologic interventionsCulture systemCell diseaseSimilar dose
2007
A Case of HPP with a Novel Combination of α and β Spectrin Mutations.
Natarajan K, Kutlar F, Li T, Gallagher P, Kutlar A. A Case of HPP with a Novel Combination of α and β Spectrin Mutations. Blood 2007, 110: 1736. DOI: 10.1182/blood.v110.11.1736.1736.Peer-Reviewed Original ResearchAfrican American femalesNon-immune hemolytic anemiaOld diagnosisHistory of splenectomySickle Cell CenterYear old black femaleAmerican femalesHereditary pyropoikilocytosisPathologic examRBC fragmentationEarly satietyPeripheral bloodClinical syndromeRed cell morphologyMonths durationHemolytic anemiaClinical examSevere formLifelong historyAutosomal recessive mannerRed pulpPatientsBlood disordersMembrane cytoskeleton proteinsAge 15
1991
An Insertional Frameshift Mutation of the β-Spectrin Gene Associated With Elliptocytosis in Spectrin Nice (β220 216)
Tse W, Gallagher P, Pothier B, Costa F, Scarpa A, Delaunay J, Forget B. An Insertional Frameshift Mutation of the β-Spectrin Gene Associated With Elliptocytosis in Spectrin Nice (β220 216). Blood 1991, 78: 517-523. DOI: 10.1182/blood.v78.2.517.517.Peer-Reviewed Original ResearchAn insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).
Tse W, Gallagher P, Pothier B, Costa F, Scarpa A, Delaunay J, Forget B. An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216). Blood 1991, 78: 517-23. PMID: 2070088, DOI: 10.1182/blood.v78.2.517.bloodjournal782517.Peer-Reviewed Original Research