2012
Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis
Cooney JD, Hildick-Smith GJ, Shafizadeh E, McBride PF, Carroll KJ, Anderson H, Shaw GC, Tamplin OJ, Branco DS, Dalton AJ, Shah DI, Wong C, Gallagher PG, Zon LI, North TE, Paw BH. Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology 2012, 373: 431-441. PMID: 22960038, PMCID: PMC3532562, DOI: 10.1016/j.ydbio.2012.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCloning, MolecularConserved SequenceDNA-Binding ProteinsEmbryo, NonmammalianEpistasis, GeneticErythropoiesisEvolution, MolecularGene Expression Regulation, DevelopmentalHematopoiesisHematopoietic Stem CellsHematopoietic SystemModels, BiologicalMolecular Sequence DataZebrafishZebrafish ProteinsConceptsHematopoietic stem cellsTranscription factorsDefinitive hematopoiesisRUNX-1Hematopoietic stem/progenitor cell developmentKey hematopoietic transcription factorsC-MybDefinitive hematopoietic progenitorsHematopoietic transcription factorsProgenitor cell developmentLineage specificationPrimitive hematopoiesisGfi1aaEpistatic relationshipErythroid developmentTranscriptional programsGFI1BHematopoietic lineagesFunctional analysisCritical regulatorCell developmentZebrafishHematopoietic progenitorsDistinct rolesPrimitive progenitors
2011
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo
Isern J, He Z, Fraser ST, Nowotschin S, Ferrer-Vaquer A, Moore R, Hadjantonakis AK, Schulz V, Tuck D, Gallagher PG, Baron MH. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood 2011, 117: 4924-4934. PMID: 21263157, PMCID: PMC3100699, DOI: 10.1182/blood-2010-10-313676.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell LineageCytokinesDNA PrimersEpsilon-GlobinsErythroid Precursor CellsErythropoiesisFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Regulatory NetworksGlycolysisGreen Fluorescent ProteinsGrowth SubstancesMaleMiceMice, Inbred ICRMice, TransgenicOxygenPregnancyRecombinant Fusion ProteinsRNA, MessengerSignal TransductionConceptsPrimitive erythroid progenitorsMouse embryosErythroid progenitorsGlobal expression profilesEmbryonic day 7.5Critical regulatory factorKey regulatory pathwaysOnset of circulationFirst transcriptomeRemarkable proliferative capacityTranscript diversityTransgenic reporterTranscriptome analysisFirst cell typeRegulatory pathwaysHematopoietic lineagesExpression profilesRegulatory factorsCell typesDay 7.5EmbryosProgenitorsYolk sacBlood progenitorsGlycolytic profile