Patrick Buckley
About
Biography
I am a graduate student pursuing a Ph.D. in Microbiology. I research the function and potential uses of short cell-penetrating peptides in the laboratory of Dr. Daniel DiMaio. My interests include virology, science communication, science policy, and photography.
Education & Training
- BS
- SUNY Geneseo, Biochemistry (2019)
- Summer Research Student
- University of Pittsburgh (2018)
- Summer Scholar
- University of Rochester (2017)
Research
Publications
2024
T cell receptor inhibition with conditional transmembrane peptide
Ye Y, Morita S, Chang J, Buckley P, Wilhelm K, DiMaio D, Groves J, Barrera F. T cell receptor inhibition with conditional transmembrane peptide. Biophysical Journal 2024, 123: 510a. DOI: 10.1016/j.bpj.2023.11.3079.Peer-Reviewed Original Research
2023
Sequence-independent activity of a predicted long disordered segment of the human papillomavirus type 16 L2 capsid protein during virus entry
Oh C, Buckley P, Choi J, Hierro A, DiMaio D. Sequence-independent activity of a predicted long disordered segment of the human papillomavirus type 16 L2 capsid protein during virus entry. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2307721120. PMID: 37819982, PMCID: PMC10589650, DOI: 10.1073/pnas.2307721120.Peer-Reviewed Original ResearchConceptsAmino acid sequenceAcid sequenceProtein segmentsVirus traffickingUnrelated cellular proteinsSequence-independent mannerIntracellular virus traffickingActivity of proteinsAmino acid segmentComplex biological functionsVirus entryTandem arraysProtein functionTrafficking factorsCellular proteinsEndosome membraneBiological functionsHPV16 pseudovirus infectionCellular factorsDiverse sequencesL2 capsid proteins
2020
TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection
Reilly EC, Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, Yang H, Oakes PW, Topham DJ. TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 12306-12314. PMID: 32439709, PMCID: PMC7275699, DOI: 10.1073/pnas.1915681117.Peer-Reviewed Original ResearchConceptsCD8 T cellsFunction of CD103Influenza virus infectionT cellsVirus infectionPeripheral tissuesTissue-resident memory CD8 T cellsVirus-specific CD8 T cellsMemory CD8 T cellsRole of CD69Site of infectionCell surface phenotypeT cell motilityMemory subsetsWk postinfectionSurface phenotypeCD103Pulmonary systemCD49aInfectionCD69Host resistanceTissueCellsExpression patterns